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1.
《国际泥沙研究》2016,(2):139-148
Applications of sediment transport and water flow characteristics based sediment transport simulation models for a river system are presented in this study. An existing water–sediment model and a new sediment–water model are used to formulate the simulation models representing water and sediment movement in a river system. The sediment–water model parameters account for water flow characteristics embodying sediment transport properties of a section. The models are revised formulations of the multiple water inflows model describing water movement through a river system as given by the Muskingum principle. The models are applied to a river system in Mississippi River basin to estimate downstream sediment concentration, sediment discharge, and water discharge. River system and the river section parameters are estimated using a revised and the original multiple water inflows models by applying the genetic algorithm. The models estimate downstream sediment transport rates on the basis of upstream sediment/water flow rates to a system. Model performance is evaluated by using standard statistical criteria;downstream water discharge resulting from the original multiple water inflows model using the estimated river system parameters indicate that the revised models satisfactorily describe water movement through a river system. Results obtained in the study demonstrate the applicability of the sediment transport and water flow characteristics-based simulation models in predicting downstream sediment transport and water flow rates in a river system.  相似文献   

2.
Mercury(Hg) is a global pollutant and can be accumulated in the food chain, posing exposure risks to humans. In this study, rice plants and corresponding rhizosphere soil samples were collected from a watershed of the Wawu River Basin that is heavily impacted by historic Hg mining and retorting activities. Total mercury(THg)and methylmercury(MeHg) in rice grains, as well as other tissues and soil samples, were measured. Five soil Hg fractions, as well as soil parameters, were also determined.The results show that the average concentrations of THg and MeHg in rice grains were 14 ± 7.0 lg kg-1 and7.2 ± 4.0 lg kg-1. Soil organic-bound(Hg-o) and strong complex-bound(Hg-s) were the main Hg fractions,accounting for 44% of the total. To estimate the Hg–ligand interaction in the soils, soil-N/Hg(R = 0.451, p \ 0.05),-S/Hg(R = 0.372, p \ 0.1), and-OM/Hg ratio(R = 0.320,p \ 0.5) with MeHgsoil were observed with significant positive correlations, indicating that the formation of Hg–OM, Hg–N–OM or Hg–S–OM complexes could prevent Hg(II) from methylation in soils. The significant positive correlations of the-N/Hg ratio,-S/Hg ratio and-OM/Hg ratio with MeHg in rice tissues suggested that Hg methylation and MeHg demethylation occurred throughout the rice paddy ecosystem. The estimated MeHg daily intake(EDI) was 0.075 ± 0.041 lg kg-1 bw d-1 and was lower than the RfD level of 0.1 lg kg-1 bw d-1 recommended by the US EPA. However, approximately 29% of the hazardous index(HI) of MeHg in grain exceeded 1, posing a potential threat to local populations, particularly pregnant women and children.  相似文献   

3.
Hyperconcentrated flows often occur in the middle and lower Yellow River(MLYR)and its tributaries,within which the main sediment source originates from the Loess Plateau of China due to serious water erosion.Little is known about the properties of river sediment that is transported by hyperconcentrated flows,particularly with respect to the mineral composition and size distribution.Samples of sediment and loess were collected in the northern,middle,and southern Loess Plateau and the mainstream and tributaries of the MLYR.A total of 18 loess samples and 24 river sediment samples were analyzed to determine their sediment size distribution and mineral composition.The bottom loess samples reflected the original sedimentary features of the Loess Plateau,and the median particle size reduced,and the clay content increased from the north to the south of the study region.The surface loess has been weathered under the action of wind and rainfall,and the clay particle content in the surface loess samples was higher than that in the undisturbed bottom loess.Erosion of the surface soil due to rainfall and surface runoff means that fine particles(mostly clay)have been washed away.The median diameter of surface loess particles was a little larger than that of the bottom loess particles where water erosion dominates.The particle size became coarser with increasing distance from the estuary in the MLYR,which reflects depositional sorting in the river channel.Significant logarithmic relations were found between the median diameter of the sediment particles and the i)non-clay mineral content and ii)clay mineral content.Thus,clay and non-clay mineral compositions can be conveniently estimated from the particle size distribution.  相似文献   

4.
I. CHAncEL CHANGal m THE FLOODED AREA ArVER BREACHING AT TONGWAXIANG AND THEIR IMPACTSIn mid--June of 1855 a great flood occurred in the lower reaches of the Yellow River. The findmainly came down from the main stem of the river and itS tributary Qinhe River. In the meantimethe riparian area of the Yellow River had just been subjected to a heavy rain, and large amountS of water from mountains and hills were flowing into the river and lakes were also full. The Weis…  相似文献   

5.
Little information exists on the potential of soil enzyme activities,which are sensitive to soil properties and management,for the characterization of sediment sources at the catchment scale.The objective of this study is to explore and evaluate enzyme activity as tracer for sediment fingerprinting in the Hiv catchment(55 km~2),Iran.Therefore,four enzymes were measured from 42 different sampling sites,covering three sediment source areas(rangeland/surface erosion,orchard/surface erosion,and streambank erosion),as well as from 12 sediment samples from reservoir check dams (sediment sinks).The results indicate that,based upon backward mode discriminant analysis,βglucosidase and dehydrogenase,allowed more than 95%of the samples to be correctly assigned to their source areas.These enzymes were selected as input data for a mixing-model to determine the relative contribution of the sampled sediment sources.The mean contributions from rangeland, orchard and streambank sources in the study area were estimated as 11.3%,15.1%and 73.7%, respectively.Using geochemical tracers,the mean contribution from rangeland,orchard and streambank sources was estimated as 14.1%,9.5%and 74.8%,respectively.Combined biochemical and geochemical tracers,similar values were obtained(18.7%,10.7%and 70.7%,respectively).Our results indicate that soil enzyme activity allows for a good characterization of sediment sources,and can provide a complementary tool to currently existing sediment fingerprinting approaches.However, the method should be also tested in other regions.  相似文献   

6.
The fluvial process of the Yalu Tsangpo River occurs concurrently with the uplift of the Qinghai-Tibet Plateau.Therefore,the river exhibits unique features in morphology and sediment deposition.Field investigations were performed from 2009–2011and the depth of the interface between the sediment deposits and bed rock was detected with an electromagnetic imaging system(EH4)at 29 cross sections.Sediment deposits were sampled along the Yalu Tsangpo valley from Xietongmen to the Yalu Tsangpo Canyon.The results show that a huge amount of sediment has been deposited in four wide valley sections because the uplift rate in these sections was lower than that in the downstream gorge sections over the past million years.About 518 billion m3of gravel and sand have been stored in the high mountain river valleys,which has changed the V-shaped mountain river valley into a U-shaped wide river valley in the four sections.In the sections with high uplift rates the river bed is incised and has formed gorges and the Yalu Tsangpo Canyon.  相似文献   

7.
The Jialingjiang River basin is one of the main sediment contributing areas in the upper reaches of the Changjiang River. Great changes have taken place in the runoff and sediment discharge in recent years. Comparing the data of 1991-2003 with the data of 1954-1990, the annual runoff of the Jialingjiang River basin decreased by 23 %, and the suspended sediment transport decreased by 74% or 105 million tons. The main factors affecting the reduction include a decrease in rainfall, sediment detention of hydraulic structures, soil and water conservation activities, sedimentation and sand dredging in the river channel. Thorough investigation and analysis of the contribution of each factor to the sediment decrease at Beibei Station was determined for the first time. The following are the contributing percentages for each factor: a decrease in runoff accounted for 32.9%; soil and water conservation measures accounted for 16.4%; sediment detention of hydraulic structures accounted for 30.5%; sedimentation, river channel sand dredging, and other factors accounted for 20.2%. These findings are very important for forecasting the trend of inflow sediment discharge variation.  相似文献   

8.
In this paper we carry out a theoretical analysis based on the general one-dimensional morphodynamic model for rivers in order to show how the morphological equilibrium of a fiver is influenced by water and sediment diversion/supply along the river. The results of the analysis show that large scale water diversions, like those along the Lower Yellow River, can cause the development of a convex riverbed profile in the long-term. Deposition will take place along the whole reach of the river, with an increasing deposition depth from downstream to upstream. The slope of the river bed increases from upstream to downstream. Furthermore, an analysis on the morphological time scale shows that this development in the Lower Yellow River will take a time period on the order of decades to centuries. The results of the analysis have been compared with observations in the Lower Yellow River. Since the second half of the 1980＇s large scale water diversions from the Yellow River have been taking place. The observations show that this has indeed led to significant sedimentation along the river.  相似文献   

9.
This study sought to contribute to an improved understanding of soil erosion and redistribution on Mediterranean agricultural land, where traditional soil conservation practices have been applied over millennia to provide effective protection of cultivated land. The study was undertaken in the Na Borges catchment, a groundwater-dominated lowland limestone basin (319 km2), located in the northeastern part of Mallorca, Spain. The average sediment yield from the basin, based on river sediment load data, is 1 t/km2·yr. The 137Cs technique was used to quantify soil redistribution rates over the past 40 years and to identify the key factors involved in soil erosion and redistribution processes. To estimate erosion and deposition rates and to elucidate the main factors affecting soil redistribution, samples were collected from six slope transects representative of the local land use and slope gradients and the presence or absence of soil conservation practices. A mass balance and a profile distribution conversion model were used for cultivated areas and areas of natural vegetation, respectively, to derive point estimates of the soil redistribution rates from the 137Cs inventories measured for individual soil bulk cores. In areas without soil conservation practices, the estimated mean soil erosion rates ranged from 12.7 to 26.4 t/ha·yr, which correspond to the slight and moderate erosion classes. The erosivity of Mediterranean climatic conditions combined with the influence of agricultural practices and slope gradient on soil erosion, represent the main factors responsible for the variation of soil losses documented for the cultivated land located in downslope areas, in the absence of soil conservation practices. Deposition dominated for those transects affected by soil conservation practices, with rates ranging between 18.8 and 96.6 t/ha·yr. However, this situation does not mean that soil conservation measures retain all the sediment, but rather that agriculture and urbanization (i.e. new rural paths and stone boundaries) modified the micro-topography and diverted sediment from other upslope zones towards the slopes where sampling transects were located.  相似文献   

10.
The process of urbanization aggravates the endogenous pollution of urban lake sediment,and polluted sediment may seriously affect the quality of the water in lakes.At present,it is difficult to distinguish the difference between sediment that is heavily polluted by nitrogen(N)and phosphorus(P)when using an analysis based on a physicochemical index classification.The current study applied phospholipid fatty acid(PLFA)technology to further analyze the sediment characteristics from the perspective of microbiology.Surface sediment from five urban lakes that are heavily polluted with N and P in Wuhan were sampled.Statistical approaches were used to analyze the microbial community structure in the sampled sediment,and to determine the correlations between the microorganisms and physicochemical indices.The most severely polluted lake sediment had similar PLFA structures,the highest saturated fatty-acid content,and bacteria as the dominant microorganism.However,there were differences between the microbial biomass of the various sediment samples,which may have been related to the degree of N and P pollution.Analysis of the microbial diversity in the sediment samples indicated that the bacteria were experiencing starvation and nutrient pressure,which may have been due to the dissolved oxygen concentration of the heavily polluted lake sediment.A correlation analysis showed that the endogenous N and P had different effects on the microbes of the polluted sediment.A redundancy analysis(RDA)demonstrated that the N/P ratio had the greatest influence on the PLFA species,accounting for 83%of the cumulative interpretation.To effectively promote the role of sediment microorganisms on circulating elements,it is necessary to regulate the N/P ratio of the sediment to some extent.When the N/P ratio in sediment exceeds 6,N pollution should be prioritized.  相似文献   

11.
Macroinvertebrates in the bed sediment of the Yellow River   总被引：1，自引：1，他引：0  
Extensive agricultural,industrial and urban development in the Yellow River,China,have modified the sediment-water balance,flow and inundation regimes,longitudinal connectivity,integrity of riparian vegetation,and water quality.Macroinvertebrate assemblages in the bed sediment of main channel and major reservoirs of the Yellow River are described in detail for the first time.A total of 74 taxa comprising 17 taxa of oligochaetes,48 taxa of aquatic insects,5 taxa of molluscs,and 4 taxa of other animals were recorded.A range of feeding guilds were represented,including, collector-gatherers(32 taxa),predators(17 taxa),scrapers(16 taxa),shredders(6 taxa)and collector-filterers(2 taxa).Both the mean density and biomass of macroinvertebrates were significantly higher in sites located in the artificial reservoirs compared with the main river channel. Assemblages varied spatially;Oligochaetes dominated assemblages in upper reaches,insects dominated in middle reaches and other animals(e.g.Crustacea)dominated in lower reaches. Collector-gatherers were dominant throughout the entire river.Classification analysis identified five site-groups on the basis of macroinvertebrate presence/absence:downstream of reservoirs;vegetated sites;reservoir sites;polluted sites,and;lower-reach sites.Lower macroinvertebrate richness,density and biomass,compared with other similar large rivers,were attributed to modification of the sediment-water balance and associated disturbance of benthic habitats.Pollution,stability of sediment and sediment concentration combined to influence the distribution of macroinvertebrates.This knowledge will substantially benefit the recent focus on the health and environmental water requirements of the Yellow River.  相似文献   

12.
Elemental sulfur(ES) is a component essential for proper development of animals, but it can be toxic for aquatic organisms. The objectives of the study reported here included determination of ES concentrations in sediment collected in the area of the Gulf of Gdansk(Baltic Sea) and search for the possible correlations with the ecotoxicity results. Sediment samples were collected from four locations: the Vistula River mouth, in the Port Basin, in the area of discharge of the treated wastewater from the Wastewater Treatment Plant(WWTP) and in the area of the sunken World War Ⅱ s/s 'Stuttgart' shipwreck. The levels of elemental sulfur were determined using a gas chromatograph coupled with a mass spectrometer(GC-MS). Toxicity of marine sediment samples was estimated for three biotest organisms-bioluminescent bacteria Vibrio fischeri, crustacean Heterocypris incongruens, and Synapis alba plant. The highest toxicity of sediments for all indicator organisms was observed in samples taken at the place of the shipwreck(2-100%). The same samples had a high sulfur content(16.7-143.2 μg/g dry weight(d.w.))therefore, it was decided to investigate whether the presence of ES in the sediment in the studied area can have an impact on the results of the ecotoxicity determination in real samples. However, the removal of sulfur from the samples resulted in no significant changes in the level of toxicity of the samples. In this research it could not be confirmed that the presence of elemental sulfur is the only factor responsible for the observed sediment toxicity. It seems that other compounds or their mixtures present in the sediment may have a significant influence on the results obtained.  相似文献   

13.
Soil erosion in catchment areas reduces soil productivity and causes a loss of reservoir capacity. Several parametric models have been developed to predict soil erosion at drainage basins, hill slopes and field levels. The well-known Universal Soil Loss Equation （USLE） represents a standardized approach. Miyun reservoir, which sits on Chaobaihe River, is the main surface source of drinking water for Beijing, the capital of China. Water and soil loss are the main reasons for sediment to enter a reservoir. Sediment yield is assessed using a version of the universal soil loss equation modified by Chinese researchers. All year 2001 and 2002 data for factors in the equation are obtained from remote sensing or collected to form an analysis database. These factors are computed and mapped using Geographic Information System tools. Based on the complex database, the modified model is developed. Through pixel-based computing the sediment yield per hydrological unit is calculated. The model does not consider sediment deposition occurring on hillslopes. Gross soil loss is often higher than the sum of those measured at catchment outlets. The sediment delivery ratio （SDR） per hydrological unit is also computed. This study analyzes the main contributions of sediment yields on sub-basins of the Chaobaihe River to the Miyun Reservoir, and discusses the possible reasons for the difference between SDRs in 2001 and 2002 at different outlets. The result shows that in the upper basin of the Miyun Reservoir, in 2001 the area of erosion that could be neglected was 8,202.76 km^2, the area of low erosion 3,269.59 km^2, the area of moderate erosion 3,400.97 km^2, the area of high erosion 436.89 km^2, the area of strong erosion 52.19 km^2 and the area of severe erosion 3.13 km^2. The highest soil loss was 70,353 t/km^2. yr in Fengning County in 2001, followed by 64,418 t/km^2. yr by Chicheng County in 2001. The SDR in 2002 was lower than that in 2001. The main reasons are the decreasing rainfall erosivity and total runoff.  相似文献   

14.
Concentrations of suspended particle material(SPM), dissolved silicate(DSi), biogenic silica(BSi), phytoliths(plant produced siliceous microscopic structures), and other parameters were analyzed to examine the influence of both natural processes and human activities on silica delivery to the estuary of the Huanghe River(Yellow River). Our results indicate that the concentrations of DSi in the river decreased significantly since 1986. Approximately 34% of dissolved silica was trapped in the basin between 1986 and 2010 due to a reduction of soil erosion. Phytoliths comprised 67.2%–96.3% of BSi, with the smoothing bar type being the dominant form. Concentrations of BSi are significantly higher in the Huanghe River compared to other major rivers throughout the world due to its high sediment yield. We also found that the ratios of BSi/(BSi+DSi) and BSi/SPM were approximately 0.5 and 0.003 at Lijin near the river mouth, indicating that BSi carried in suspension by the Huanghe River was an important component of the rivers silica load. Significant amounts of BSi were also composed of phytoliths in Bohai Sea sediments near the Huanghe River estuary with the smoothing bar form again being the most abundant. The relatively high specific fluxes of BSi in the Huanghe River reflect its high turbidity and high erosion rates in the basin. The high sediment load originating on the Loess Plateau is likely responsible for the higher BSi flux, in agreement with a general trend of increasing BSi flux with increasing sediment flux in global river systems. This study demonstrates that BSi transported by rivers can be composed largely of phytoliths originating from the erosion of topsoils. The flux of phytoliths in river's suspended sediment load may therefore represent a significant contribution to the biogeochemical cycle of silica in coastal waters.  相似文献   

15.
The soil pollution by heavy metals was characterized in the mine tailings and surrounding soils of an old Pb–Zn mine in Huize County. Three hundred and ninety-six samples of agricultural and non-agricultural soil were analyzed for the total metal concentration by acid digestion and sixty-eight selected soil samples were used to determine the chemical fractionation of heavy metals with the modified BCR sequential extraction method. The pollution index of the heavy metals indices for As, Cd, Cr, Cu,Hg, Pb and Zn of non-agricultural soil and agricultural soils in the study area indicated the spreading of heavy metal pollution. Sequential extraction showed that most of Cd existed in an exchangeable form(31.2 %). The available content of Pb, Cu and Zn was mainly distributed in acid extractable fractions and Fe/Mn oxide fractions(27.9, 30 and 27.2 %), and Hg, As and Cr were mainly associated with residual fractions(90.4, 72.9 and 76.8 %). The risks of heavy metals were also evaluated by the risk assessment code(RAC) and potential ecological risk index, respectively. The results of RAC showed a medium and high risk of Cd(45.6 and 54.4 %), medium risk of Zn(100 %), low and medium risk of Cu(41.2 and 58.8 %), largely no risk of Hg(97.1 %), and mainly low risk of As and Pb(92.6and 91.8 %). The range of the potential ecological risk of soil was 58.2–1839.3, revealing a considerably high ecological risk in the study area, most likely related to acid mine drainage and the mining complexes located in the area. The results can be used during the ecological risk screening stage, in conjunction with the total concentrations and metal fractionation values, to better estimate ecological risk.  相似文献   

16.
Rocky desertification has become a major environmental issue in the karst region of southwestern China.Karst rocky desertification was more severe in regions of limestone soil than in adjacent regions of other soils,despite the relatively higher soil organic matter(SOM)content in limestone soil. The underlying mechanism remains ambiguous. We speculated that the geochemical characteristics of limestone soils in the karst region plays an essential role, especially the high calcium content of limestone soil. To test this hypothesis, we collected limestone soil samples from a limestone soil profile in the southwestern China karst region and extracted humic acid(HA) from these limestone soil samples. We investigated the interaction of Ca~(2+)and three HA samples on a joint experimental platform, which consists of an automatic potentiometric titrator, a UV–visible spectrometer, and a Fluorescence spectrometer. HA solutions were titrated by Ca~(2+)and optical spectra of the HA solutions were monitored during the titration experiments. The results indicated that:(1) the interaction of Ca~(2+)and HA is a combined process of adsorption and complexation. Adsorption dominated the overall distribution behavior of Ca~(2+), which could be fit by Langmuir and Freundlich isotherm models.Complexation was distinguished only when the concentration of Ca~(2+)is low;(2) the changes of UV–visible spectroscopy and excitation–emission matrix fluorescencespectroscopy spectra of HA samples when they were binding with Ca~(2+)implied the apparent molecular size and structure of HA became larger and more complex;(3) the combination of Ca~(2+)and HA plays an important role in the SOM preservation of limestone soils but the stability of the Ca–HA association was relatively weak. The present study draws attention to maintaining the relatively higher Ca~(2+)concentration in limestone soils in ecologic restoration attempts in karst regions.  相似文献   

17.
Dam break flows and resulting river bed erosion can have disastrous impacts on human safety,infrastructure,and environmental quality.However,there is a lack of research on the mobility of non-uniform sediment mixtures resulting from dam break flows and how these differ from uniform sized sediment.In this paper,laboratory flume experiments revealed that coarse and fine fractions in non-uniform sediment had a higher and a lower bed-load parameter,respectively,than uniform sediments of the same size.Thus,the finer fractions were more stable and the coarser fractions were more erodible in a nonuniform bed compared to a uniform-grained bed.These differences can be explained by the hiding and protrusion of these fractions,respectively.By investigating changes in mobility of the mixed-size fractions with reservoir water levels,the results revealed that at low water levels,when the coarser fractions were only just mobile,the bed-load parameter of the finer fractions was higher than the coarser fractions.The opposite was observed at a higher water level,when a significant proportion of the coarsest fractions was mobilized.The higher protrusion of these grains had an important effect on their mobility relative to the finer grains.The transported sediment on these mixed-sized beds was coarser than the initial bed sediment,and became coarser with an increase in reservoir water level.  相似文献   

18.
1 INTRODUCTION The construction of more than 75,000 dams and reservoirs on rivers in the United States (Graf, 1999) has resulted in alteration of the hydrology, geometry, and sediment flow in many of the river channels downstream of dams. Additionally, hydrologic and geomorphic impacts lead to changes in the physical habitat affecting both the flora and fauna of the riparian and aquatic environments. Legislation for protection of endangered species as well as heightened interest in ma…  相似文献   

19.
Most of the studies on Artificial Neural Network (ANN) models remain restricted to smaller rivers and catchments. In this paper, an attempt has been made to correlate variability of sediment loads with rainfall and runoff through the application of the Back Propagation Neural Network (BPNN) algorithm for a large tropical river. The algorithm and simulation are done through MATLAB environment. The methodology comprised of a collection of data on rainfall, water discharge, and sediment discharge for the Narmada River at various locations (along with time variables) and application to develop a threelayer BPNN model for the prediction of sediment discharges. For training and validation purposes a set of 549 data points for the monsoon (16 June-15 November) period of three consecutive years (1996–1998) was used. For testing purposes, the BPNN model was further trained using a set of 732 data points of monsoon season of four years (2006–07 to 2009–10) at nine stations. The model was tested by predicting daily sediment load for the monsoon season of the year 2010–11. To evaluate the performance of the BPNN model, errors were calculated by comparing the actual and predicted loads. The validation and testing results obtained at all these locations are tabulated and discussed. Results obtained from the model application are robust and encouraging not only for the sub-basins but also for the entire basin. These results suggest that the proposed model is capable of predicting the daily sediment load even at downstream locations, which show nonlinearity in the transportation process. Overall, the proposed model with further training might be useful in the prediction of sediment discharges for large river basins.  相似文献   

20.
The purpose of the current study is to compare the influence of different aerobic conditions(biostimulation(BS),bioaugmentation(BA),and a combination of biostimulation and bioaugmentation(BB))on polycyclic aromatic hydrocarbons(PAH)degradation and compare the degraded amount with single step XAD-4 extraction as a new tool for bioavailability assessment for chronically contaminated sediment samples obtained from territory of Autonomous Province Vojvodina of Serbia(S1,S2,and S3).A great number of papers dealing with biodegradation of PAHs in spiked sediment or soil have been published,but to the authors’knowledge,a limited number of papers studied aged,historically polluted sediment and a sum of chosen U.S.Environmental Protection Agency(USEPA)PAHs.A significant reduction(up to67%)in PAH concentration was observed,while the percentage of reduction varied depending on the sediment sample and treatment used.BS treatment successfully stimulated growth of indigenous bacteria.Further,PAH-degrading strain Sphingomonas paucimobilis F8 inoculated in BA and BB treatment survived for up to 7 weeks after it was suppressed by unfavorable conditions or native microbes.Degraded amounts generally showed good correlation with results obtained from XAD-4 extraction.Results obtained in the current study represent a good start for standardizing a XAD-4 extraction technique as a simplified,easier,and lower cost method for bioavailability assessment.  相似文献   

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