首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 421 毫秒
1.
观察偏头痛大鼠炎症因子的表达及电针干预对其的影响,探讨电针在偏头痛中发挥镇痛效应的相关机制。方法:24只SD大鼠随机分为假手术组、模型组、模型+电针组,每组8只。采用电刺激右侧三叉神经节制备偏头痛模型,取右侧“风池”“外关” 穴进行电针治疗,ELISA法检测各组大鼠血清TNF-α、IL-1β、IL-6浓度。结果:血清TNF-α、IL-1β、IL-6浓度模型组、模型+电针组均明显高于假手术组(P<0.05),模型+电针组较模型组降低(P<0.05)。结论:电针干预可降低偏头痛大鼠血清TNF-α、IL-1β、IL-6浓度,这可能是电针在偏头痛中发挥镇痛效应的相关机制之一。  相似文献   

2.
目的:研究苦参汤对皮肤溃疡大鼠伤口愈合的影响。方法:通过皮下注射75%冰醋酸诱导大鼠皮肤溃疡模型,将模型大鼠分为5组,G1采用蒸馏水干预,G2~5分别采用苦参汤低、中、高剂量及0.02%高锰酸钾溶液(PP)进行局部治疗,连续7d。治疗后对各组溃疡面积、溃疡评分和组织学评估,通过免疫组织化学分析检测前炎性细胞因子前列腺素E2(PGE-2)和白细胞介素-8(IL-8)的表达。结果:苦参汤对皮肤溃疡大鼠创口愈合有促进作用,中剂量和高剂量苦参汤治疗的大鼠溃疡愈合更佳(P<0.05),低剂量苦参汤治疗的肉眼可见溃疡评分显著降低(P<0.01),PP组在降低溃疡面积和肉眼可见的溃疡评分方面,差异无统计学意义(P>0.05);所有剂量的苦参汤和PP均改善了大鼠诱导的皮肤溃疡的组织学损伤;高剂量苦参汤和PP使大鼠皮肤溃疡组织中的PGE-2和IL-8表达显著降低(P<0.01);各组大鼠均未发现与治疗有关的毒性。结论:苦参汤可促进皮肤溃疡大鼠的伤口愈合,其对PGE-2和IL-8的抑制是增强伤口愈合的可能作用机制。  相似文献   

3.
目的:观察温肺降浊方对血管性痴呆(VaD)大鼠Nogo-A和NgR mRNA及其蛋白表达的影响。方法:将30只大鼠随机分为假手术组、模型组、中药组,每组各10只。采用双侧颈总动脉永久性结扎方法制作VaD大鼠模型,造模成功后中药组予温肺降浊方灌胃,假手术组、模型组予以等量0.9%氯化钠注射液灌胃,疗程均为4周。采用Morris水迷宫行为学测试大鼠学习记忆能力;RT-PCR、Western blot检测各组大鼠Nogo-A和NgR mRNA及其蛋白表达水平,透射电镜观察神经元突触结构变化。结果:与假手术组比较,模型组大鼠逃避潜伏期延长、穿越平台次数减少(P<0.01或P<0.05);海马中Nogo-A和NgR蛋白及mRNA表达增多(P<0.01)。与模型组比较,中药组逃避潜伏期缩短、穿越平台次数增加(P<0.05);海马中Nogo-A和NgR mRNA及其蛋白减少(P<0.05)。海马神经元突触及细胞器完整、突触间隙及小泡正常。结论:温肺降浊方可改善VaD大鼠学习记忆能力,其机制可能与降低Nogo-A和NgR mRNA及蛋白表达含量,促进神经突触再生,改善海马突触可塑性有关。  相似文献   

4.
为比较短蛸(Octopus ocellatus)对不同生物饵料的利用效果,以南美白对虾、肉球近方蟹、菲律宾蛤仔和玉筋鱼四种饵料进行了饲喂实验。结果表明:1)肉球近方蟹组短蛸增重率显著高于其他各组(P<0.05),南美白对虾组脏体比显著高于玉筋鱼组(P<0.05),各饵料组肝体比无显著差异;2)南美白对虾组和肉球近方蟹组短蛸肌肉的蛋白质含量显著高于菲律宾蛤仔组和玉筋鱼组(P<0.05),肉球近方蟹组脂肪含量显著高于其余各组(P<0.05),玉筋鱼组灰分含量显著低于其他各组(P<0.05);3)南美白对虾组短蛸肝胰腺谷丙转氨酶活性显著高于其余各组(P<0.05),肉球近方蟹组谷草转氨酶活性显著高于其余各组(P<0.05),玉筋鱼组谷氨酸脱氢酶活性显著低于其余各组(P<0.05),菲律宾蛤仔组酸性磷酸酶活性显著高于其余各组(P<0.05),玉筋鱼组胃蛋白酶活性显著高于其他各组(P<0.05)。综上,投喂肉球近方蟹可以显著提高短蛸的增重率;不同饵料对短蛸肌肉的蛋白质、脂肪和灰分含量有影响,对其肝胰腺功能和胃蛋白酶活性也有显著影响。  相似文献   

5.
为开发藻类活性物质的药用价值,探究了藻蓝蛋白(phycocyanin,PC)对四氯化碳(CCl4)诱导的大鼠肝纤维化的影响。试验中将大鼠随机分为3组,分别为对照组、肝纤维化组、CCl4+PC干预组。利用CCl4腹腔注射诱导肝损伤模型,在干预后,通过RT-PCR技术检测了大鼠肝脏中纤维化标志物I型胶原蛋白(collagen type I,Co-I)和α-平滑肌肌动蛋白(alpha-smooth muscle actin,α-SMA)的表达情况,通过16S rRNA高通量测序技术检测了干预后大鼠肠道微生物的组成和结构。RT-PCR结果显示PC干预显著降低了CCl4诱导的大鼠肝脏中纤维化标志物α-SMA和Co-I的表达。CCl4诱导使大鼠肠道菌群发生了紊乱,显著降低了具有抗炎活性的益生菌Bacteroides、Blautia、Parabacteroides的丰度,PC干预显著增加了具有抗炎活性的益生菌Blautia的丰度。结果表明PC能够改善CCl4引起的肠道菌群紊乱,这种改善可能有助于缓解CCl4导致的肝纤维化。  相似文献   

6.
目的:观察旋扳手法联合机械牵引治疗腰椎间盘突出症(LDH)的临床疗效。方法:将76例LDH患者随机分为治疗组和对照组,每组各38例。对照组采用机械牵引治疗,治疗组在对照组的基础上联合旋扳手法治疗。对比分析2组综合疗效、疼痛视觉模拟评分法(VAS)评分、改良下腰痛日本骨科协会评估治疗分数(JOA)评分及炎性因子。结果:总有效率治疗组为86.8%(33/38),对照组为73.7%(28/38),2组比较,差异有统计学意义(P<0.05)。2组VAS、JOA评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。2组治疗后炎性因子水平均较治疗前下降(P<0.05),治疗组IL-1β、TNF-α较对照组下降更明显(P<0.05)。结论:采用旋扳手法联合机械牵引治疗LDH,具有减轻疼痛、恢复功能和消除炎症的效果,安全性及可操作性高,值得临床推广。  相似文献   

7.
目的:观察解郁降压颗粒结合音乐疗法对围绝经期高血压病模型大鼠性激素的调节作用,初步探讨解郁降压颗粒结合音乐疗法治疗围绝经期高血压病的可能机制。方法:选用动情周期规律的SPF级雌性自发性高血压(SHR)大鼠,将其随机分成SHR组、假手术组、围绝经期高血压病模型组(简称模型组)、解郁降压颗粒加音乐疗法组(简称治疗组);另设WKY大鼠作为正常血压对照组。通过摘除双侧卵巢方法建立围绝经期高血压病模型,待造模成功后,予以相应干预。治疗结束后测量血清雌二醇(E2)、促卵泡生成素(FSH)、促黄体生成素(LH)的含量,同时测量大鼠动脉血管的平均光密度值(OD值)。结果:与SHR组比较,治疗组血压下降,差异有统计学意义(P<0.05);与模型组比较,治疗组E22上升,OD值上升,FSH、LH含量下降,差异均有统计学意义(P<0.05)。结论:解郁降压颗粒结合音乐疗法对围绝经期高血压病模型大鼠有降压作用,且能提高SHR模型大鼠血清E22的含量,降低FSH、LH含量,改善SHR模型大鼠的内分泌环境;OD值上升,表示雌激素α受体(ERα)水平提高;而对内分泌环境的改善和ERα水平的提高可能是其降压机制之一。  相似文献   

8.
目的:观察肛三针合体穴电针治疗肛周瘙痒症的临床疗效。方法:将72例肛周瘙痒症患者随机分成治疗组与对照组,每组各36例。治疗组予肛三针合体穴电针治疗,对照组予三味清热止痒洗剂治疗,连续治疗21d。比较2组肛周瘙痒程度、苔藓样化评分及综合疗效。结果:总有效率治疗组为94.44%(34/36),对照组为77.78%(28/36),组间比较,差异有统计学意义(P<0.05)。2组肛周瘙痒、苔藓样化评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:肛三针合体穴电针能够有效改善肛周瘙痒症苔藓样化皮损,减轻患者症状及痛苦,临床疗效确切。  相似文献   

9.
目的:探讨艾灸足三里对变应性鼻炎(AR)大鼠鼻黏膜免疫功能的影响。方法:将40只SD大鼠随机分为正常组、模型组、对照组和治疗组,每组10只。采用卵清蛋白致敏法制备AR大鼠模型。造模成功后对照组与治疗组进行艾灸治疗,正常组、模型组只捆绑不艾灸,疗程14 d。观察4组行为学评分,鼻黏膜组织病理情况,分泌性免疫球蛋白A(sIgA)、CD4+、CD8+表达水平。结果:治疗后,治疗组的行为学评分较模型组降低,差异有统计学意义(P<0.05);治疗后,正常组、治疗组嗜酸性粒细胞、鼻咽冲洗液sIgA表达及CD4+、CD8+水平与模型组比较,差异均有统计学意义(P<0.05或P<0.01)。结论:艾灸足三里可改善AR大鼠行为学评分及鼻黏膜组织病理情况,降低嗜酸性粒细胞数,并能下调鼻黏膜sIgA、CD4+、CD8+表达,这可能是其治疗AR的免疫机制之一。  相似文献   

10.
为从分子水平研究饥饿对大黄鱼肌肉生长代谢的影响,本实验采用qPCR技术研究了在饥饿胁迫以及复投喂过程中胰岛素样生长因子基因IGF-Ⅰ(insulin-like growth fator-Ⅰ)、雷帕霉素靶蛋白基因mTOR(mammalian target of rapamycin)、成肌分化抗原基因MyoD(myogenic differentiation antigen)和肌球蛋白重链基因MHC(myosin heavy chain)等4个大黄鱼肌肉生长调控相关基因在肝脏、脾脏、脑、心脏、肠、鳃、肌肉和肾8个组织中的表达模式。结果显示:四个基因在正常大黄鱼不同组织间表达存在显著差异;饥饿显著降低IGF-Ⅰ在肝组织中的表达量(P<0.05),在复投喂14d时显著上升,此外在肠和鳃组织中表达量变化显著(P<0.05);mTOR表达量随着饥饿时间的延长,在脾、心和肾组织中表达量下降,在脑、鳃和肌肉组织中表达量显著升高(P<0.05);MyoD在饥饿胁迫和恢复投喂期间,在肝脏、鳃和肌肉组织中表达量变化极显著(P<0.01);饥饿和恢复投喂对MHC在鳃和肌肉中的表达影响显著(P<0.05)。结果提示饥饿可能通过调节这些肌肉生长相关基因的表达来影响肌肉的生长。  相似文献   

11.
沉积物释放是海洋环境中甲烷(CH_4)的重要来源。通过2013年7月和8月两个航次,对东、黄海泥质区沉积物中CH_4浓度的垂直分布和沉积物-水界面通量进行了研究。结果表明,除个别站位外,黄海沉积物(50 cm以浅)中CH_4的浓度变化范围在0.2~1.0μmol/L之间,长江口及浙闽沿岸附近的沉积物中CH_4浓度则要更高(1.0~2.0μmol/L),而东海东部海域沉积物中CH_4浓度波动范围为0.2~3.0μmol/L。总体来说,东、黄海沉积物中CH_4浓度偏低,这可能与观测到的高浓度硫酸盐(20 mmol/L)有关。通过整柱密室培养实验估算出东、黄海沉积物-水界面CH_4释放速率在0.64~2.12μmol/(m2·d)之间,东、黄海沉积物CH_4释放总量为6.7×108 mol/yr;但采用菲克定律估算的CH_4扩散通量则要比现场培养的结果低2~5倍,表明不同的方法在估算沉积物-水界面CH_4通量上还具有一定的不确定性。  相似文献   

12.
13.
基于普林斯顿(POM)模式,采用不同的垂直混合方案并考虑太阳短波辐射的作用,对渤海、黄海夏季垂直热结构进行了数值试验。试验结果表明,夏季波浪混合控制着渤海、黄海上混合层的形成,加入波浪混合能明显改善陆架浅海的夏季温度垂直结构。太阳短波辐射对渤海、黄海夏季上层垂直热结构有一定的作用,研究夏季海洋上层垂直热结构应该包括太阳短波辐射的影响,特别是对于水深相对较深的黄海。  相似文献   

14.
15.
In October and November 2002, high and relatively high values of the chlorophyll a concentration at the sea surface (C chl) were observed in the English Channel (0.47 mg/m3), in the waters of the North Atlantic Current (0.25 mg/m3), in the tropical and subtropical anticyclonic gyres (0.07–0.42 mg/m3), and also in the southwestern region of the southern subtropical anticyclonic gyre (usually 0.11–0.23 mg/m3). The central regions of the southern subtropical anticyclonic gyre (SATG) and the North Atlantic tropical gyre (NATR) were characterized by lower values of C chl (0.02–0.08 mg/m3 for the SATG and 0.07–0.14 mg/m3 for the NATR). At most of the SATG stations, the values of the surface primary production (C phs) varied from 2.5 to 5.5 mg C/m3 per day and were mainly defined by the fluctuations of C chl (r = +0.78) rather than by those of the assimilation number (r = +0.54). The low assimilation activity of phytoplankton in these waters (1.3–4.6 mg chl a per hour) pointed to a lack of nutrients. An analysis of the variability of their concentration and the composition of photosynthetic pigments showed that, in the waters north of 30° N, the growth of phytoplankton was mostly restricted by the deficiency of nitrogen, while, in more southern areas, at the majority of stations (about 60%), the phosphorus concentrations were the minimum. At the low concentrations of nitrates and nitrites, ammonium represented itself as a buffer that prevented planktonic algae from extreme degrees of nitric starvation. In the tropical waters and in the waters of the SATG, the primary production throughout the water column varied from 240 to 380 mg C/m2 30° per day. This level of productivity at stations with low values of C chl (<0.08 mg/m3) was provided by a well-developed deep chlorophyll maximum and a high transparency of the water. The light curves of photosynthesis based on in situ measurements point to the high efficiency of utilizing the penetrating solar radiation by phytoplankton on cloudy days.  相似文献   

16.
A relationship between paths of the Kuroshio and Kuroshio Extension (KE) is investigated, using the satellite-derived altimetry dataset of 1993–2008. When the Kuroshio takes the nearshore nonlarge meander path or typical large meander path and resultantly goes through the deeper channel (about 2500 m) of the Izu-Ogasawara Ridge, the KE path adopts a relatively stable state with the two quasi-stationary meanders. On the other hand, when the Kuroshio takes the offshore nonlarge meander path and then passes over the shallower part of the Ridge (about 1000 m), the KE path tends to be convoluted, i.e., an unstable state.  相似文献   

17.
In 1993 and 2007 when the expeditions of the Shirshov Institute of Oceanology were performed in the Kara Sea, a significant part of its aquatic area was occupied by lenses of desalinated water. The fresh-water is supplied by the runoff of the Ob and Yenisei rivers, as well as by meltwaters. The report considers the features of the freshwater chemical transformation in the sea. It is shown that the contribution of meltwaters is small in the highly desalinated lenses (with salinity below 15‰) and the freshwater is supplied by the riverine runoff. It is also shown that, under definite conditions, it is possible to determine the relative shares of the Ob and Yenisei waters using the chemical parameters (the silicon and alkalinity). The data of 1993 when two lenses as such were found in the sea were confirmed; at that, the waters of the Yenisei and Ob rivers were prevailing in the western and northeastern lenses, respectively. In 2007, one lens was found in the treated area of the sea. It is shown that the chemical characteristics of the freshwater in the lens appeared to be sufficiently different from those of the Ob river but similar to the Yenisei river’s characteristics according to the data of 1993. A map of the Ob’s and the Yenisei’s water spreading over the sea’s aquatic area is presented.  相似文献   

18.
利用2008年夏季我国第3次北极科学考察资料,基于流式细胞技术,对白令海北部陆架区的微微型浮游植物丰度、细胞大小(碳含量)、色素浓度的分布特征进行了分析,并对该类群的环境适应性进行了研究。结果表明,微微型浮游植物中仅含聚球藻和真核藻,其丰度范围分别为0.14×106 2.69×106和0.23×106-12.49×106个/dm3。聚球藻的叶绿素a和藻红蛋白含量、微微型真核藻的叶绿素a含量与类群丰度以及微微型真核藻的类胡萝卜素含量与细胞大小间均存在同向变化趋势。两类藻偏向于喜温嗜淡型,更适合在寡营养环境中保持较高的丰度,但能在高营养盐浓度下形成相对较高的碳含量。越接近陆地,细胞越小,丰度越大,碳含量及FL2/FL3越低;所处层位越深、纬度越高,则细胞越大,碳含量及FL2/FL3越高。北极气温升高和径流量的增加有利于陆架区微微型浮游植物类群丰度的增加。  相似文献   

19.
黄海、渤海沉积物中生物硅的测定及存在问题的讨论   总被引:16,自引:3,他引:16  
叶曦雯  刘素美  张经 《海洋学报》2002,24(1):129-134
硅是水生态系统中构成生物群落的重要元素[1].海洋中硅主要来源于河流输入(4.2±0.8)×1014g/a和热液喷发(1.9.77;10)×1014g/a[2].另外冰川风化、低温海底玄武岩风化、沉积物的成岩作用和大气沉降亦是其来源之一[3].沉积物中的生物硅又称生物蛋白石(简称蛋白石),指化学方法测定的无定形硅的含量,主要由硅藻、放射虫、硅鞭毛虫和海绵骨针组成.沉积物中蛋白石的积累反映了生产力在时间和空间尺度的变化[4,5].对于生物硅的测定,至今已提出了许多种方法.其中最灵敏、应用最广泛的是化学提取法[6,7].  相似文献   

20.
On the basis of the data of the complex oceanographic experiment carried out in the course of the second Ukrainian Antarctic expedition in March 1998, we study the structure and kinematics of waters in the region of the archipelago of Argentine Islands. The regularities of thermohaline stratification of waters are discovered. We determine the most important environmental parameters premoting the variability of hydrophysical fields on time scales varying from several days up to a week, analyse the data of actual observations over the currents, and estimate the relative contribtions of diurnal and semidiurnal tidal waves to the total dispersion of hydrophysical parameters of the environment. The residual currents are filtered out. We propose a hypothesis about the mechanism of their formation. Various types of tidal currents are revealed and the directions of propagation of diurnal and semidiurnal tidal waves are determined. Translated by Peter V. Malyshev and Dmitry V. Malyshev  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号