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目的：观察按压耳穴刺激耳迷走神经对APP/PSl转基因阿尔茨海默病(AD)小鼠学习记忆能力的影响,从AD模型小鼠海马区谷氨酸（Glu）阳性细胞表达、突触数量与结构变化的角度探讨按压耳穴刺激耳迷走神经治疗AD的作用机制。方法：选取8个月龄AD双转基因APP/PS1小鼠12只,按随机数字表法将其分为模型组和治疗组,每组各6只;选取同背景同月龄C57BL/6J雄性小鼠6只作为对照组。治疗组按压小鼠耳穴“心”,压力控制在(350±50)g,每隔5s按压1次,总按压时间为15 min,1次/d,7 d为1个疗程,共干预4个疗程;对照组和模型组不予任何干预。干预结束后,采用Morris水迷宫检测各组小鼠学习记忆能力,免疫组化检测各组小鼠Glu阳性细胞的表达情况,采用透射电镜观察海马区突触数量与结构变化。结果：逃避潜伏期、目标象限时间、游泳总路程、穿台次数等指标,模型组与对照组、治疗组与模型组比较,差异均有统计学意义(P<0.05);小鼠海马CA1区Glu阳性细胞表达及其MOD,海马CA1区突触结构中PSD厚度、突触间隙、突触界面曲率等指标,模型组与对照组、治疗组与模型组比较,差异均有统计学意义(P<0.05)。结论：按压耳穴刺激耳迷走神经能够改善APP/PSl转基因AD模型小鼠的学习记忆能力,其作用机制可能与调控Glu水平、增强神经元突触可塑性有关。 相似文献
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1998年11月和1999年5月长江口悬浮体样品的激光粒度仪分析结果表明，长江口悬浮体粒度较细，分选较差，偏态和峰态偏小，粒度组成以粉砂为主；粘土含量次之，基本不含砂或砂含量很小，由陆向海平均粒径有由粗到细的变化趋势。粒度分布呈典型的非正态分布，存在“双峰”和“三峰”两种形式，表层样品以“双峰”分布为主，底层“三峰”或“双峰”并存。标准偏差-粒度曲线上多峰出现，反映了长江口悬浮体组成的复杂性。长江口悬浮体粒度特征有较大的季节变化。悬浮体粒度变化的影响因素包括泥沙来源、底质再悬浮、生物作用和絮凝作用，粒度特征的季节差异是这些因素综合作用的结果。 相似文献
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福建沿海风暴潮特征的分析 总被引：7，自引：0，他引：7
通过普查1960-2001年正面登陆我国东南沿海的台风,分析了福建沿海风暴潮的特征及其可能原因。台湾海峡特殊地形对福建沿海风暴潮的时空分布有明显影响,登陆岸段不同,台湾海峡对风暴潮的影响作用也不同,导致福建沿海风暴潮出现明显不同的分布和变化特征。当台风位于台湾海峡时,其大风区位置利范围不同,会影响福建沿海各地风暴增水的幅度。台风横穿台湾海峡时,易使福建沿海台风大风区中心岸段出现双增水峰现象,第一个增水峰出现在台风离开台湾岛进入台湾海峡后,第二个增水峰出现在台风登陆福建沿海前后。台风横穿台湾海峡有时会引起台湾海峡北部出现奇异增水现象,风暴潮与天文潮之间的相互作用可能是其重要原因。奇异增水峰往往出现在天文潮低潮附近,此时实际潮位并不高。 相似文献
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利用实验室波浪水槽观测规则长波对风浪的影响。谱分析显示,较之纯风浪谱,除已被广泛关注的长波抑制风浪这一现象外,当长波波陡较小,且频率远离风浪峰频时,长波还使得风浪谱向低频移动。利用Longuet-HigginsStewart(1960)理论,并考虑到风浪破碎的约束,计算了规则长波的存在对风浪谱的影响,发现可以较好地解释这一现象。表明当长波波陡小且频率远离风浪峰频时,长波对短波的二阶调制及其引起的破碎加强可能是长波影响风浪的主要机制。 相似文献
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西北干旱区黄土-古土壤磁化率变化特征 总被引：4，自引：0，他引：4
对祁连山东段黄土-古土壤环境磁学的研究表明,在这一地区黄土-古土壤沉积中主要的磁性矿物是磁铁矿型矿物,而磁化率的增强与黄土-古土壤序列并不匹配,且存在着由剖面底部向上逐渐升高的趋势。我们认为在铁磁性矿物种类没有变化的情况下,西北干旱-半干旱区磁化率的这种增强很可能是磁性颗粒物粒度变化或者来源相关的磁性颗粒含量的变化所引起。 相似文献
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本文利用实验室波浪水槽观测规则长波对风浪的影响。谱分析显示,较之纯风浪谱,除已被广泛关注的长波抑制风浪这一现象外,当长波波陡较小,且频率远离风浪峰频时,长波还使得风浪谱向低频移动。本文利用Longuet-HigginsStewart(1960)理论,并考虑到风浪破碎的约束,计算了规则长波的存在对风浪谱的影响,发现可以较好地解释这一现象。这一工作表明,当长波波陡小且频率远离风浪峰频时,长波对短波的二阶调制及其引起的破碎加强可能是长波影响风浪的主要机制。 相似文献
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首次提出了一种间接测定悬浮粒子Stern电位的方法,即通过测定悬浮粒子在不同浓度NaCl(0.01～0.40mol/L)溶液中的ζ-电位,按照Gouy-Chapman理论一般公式之对数变换式,用作图法计算悬浮粒子的Stern电位.用该方法研究了黄河口悬浮粒子Stern电位的变化规律.结果表明,在淡、咸水混合初期,悬浮粒子的Stern电位迅速减小;当S>3.5时,Stern电位不再随盐度的增大而变化.由此提出,对Ca2+和Ms2+的吸附是影响河口悬浮粒子Stern电位变化的主要因素. 相似文献
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塔里木盆地的构造演化 总被引：6，自引：0，他引：6
从地震大剖面显示，塔里木盆地发育为手风琴式的演化史。大体上形成有3层“断-坳”结构：①震旦系的“断”，古生界-三叠系的“坳”；②侏罗系的“断”，上白垩系的“坳”；③古近系的“断”，新近系的“坳”。断陷与坳陷分别由拉张与挤压应力场所致，这种应力场的变化是由相邻洋壳板块俯冲倾角由小到大的变化所引起的。由于地壳的多旋回运动，多次发生构造沉积演变，构成了多套生储盖组合，多领域、多种圈闭类型的油气藏，从震旦系-古生界-中生界-新生界，各断陷-坳陷结构的盆地都有可能形成油气藏的地质条件。 相似文献
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走航式海洋多参数剖面测量系统(moving vessel profiler,MVP)是一种集成程度和自动化程度都较高的海洋调查设备,能对海洋多要素进行同时观测,获得水平方向的高分辨率数据资料。由于温度和电导率传感器响应时间的不匹配,MVP下放速度过快(峰值速度4 m/s)而造成非常明显的盐度尖峰现象。本研究结合Fofonoff(F)法、时间常数指数递归数字滤波(Giles and McDougall,GM)法和Grose提出的盐度尖峰订正方案,提出了一种新的方法,即MCT(match conductivity and temperature response time)法,通过对压力、温度和电导率传感器进行响应时间的匹配来减弱盐度尖峰。将SBE-9型CTD资料作为标准,发现订正后的资料与CTD盐度曲线的互相关系数为0.917,误差比订正前减小80%。对比35°N断面修正前后的盐度资料,订正后温盐跃层处出现的低盐区域消失。MVP的应用比常规海洋调查仪器CTD对于海洋现象的观测更有优势。 相似文献
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Mathieu J. Duchesne Gilles Bellefleur Mike Galbraith Randy Kolesar Rick Kuzmiski 《Marine Geophysical Researches》2007,28(2):153-164
A sparker is a marine seismic impulsive source used for high-resolution seismic surveys. Sparker sources were very popular
during the late 1960s and 1970s before being supplanted by small volume airguns. However, in the last 10 years there has been
renewed interest in sparker technology because (1) it can be easily deployed at relatively low costs and (2) in certain areas
the use of small airguns is restricted for environmental purposes. In this study a sparker source was used to assess the seismic
stratigraphy of Quaternary deposits and to image the sediment/bedrock interface. Three different inverse filtering methods
were tested (i.e., spiking deconvolution, match-filtering and vertical seismic profile (VSP) deconvolution) to correct the
poor shot-to-shot repeatability of the source and to compress its reverberations. Results show that the matched-filter and
VSP deconvolution methods, which design and apply one operator for each shot, produced comparable results, whereas the spiking
deconvolution that used the same operator on all traces failed to compress the source signature properly. 相似文献
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走航式海洋多参数剖面测量系统(MVP)是一种集成程度和自动化程度都较高的海洋调查设备,能对多要素进行同时观测,获得高水平空间分辨率的数据资料。MVP由于温度和电导率传感器响应时间的不匹配,下放速度过快(峰值速度4m/s)而造成非常严重的盐度尖峰现象。本研究通过结合F法、GM法和Grose法提出的盐度尖峰订正方案,提出了一种新的方法Match conductivity and temperature response times法,对压力、温度和电导率传感器三者进行响应时间的匹配来减弱盐度尖峰。与SBE-9型CTD资料进行对比发现订正后的资料误差比订正前减小80%,与CTD盐度曲线互相关程度为0.917。对比35N断面修正前后的盐度资料发现订正后温盐跃层处出现的低盐区域消失,与CTD断面资料对比结果显示MVP资料比CTD资料在细结构上更具有优势。 相似文献
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For many years, estuarine science has been the ‘poor relation’ in aquatic research - freshwater scientists ignored estuaries as they tended to get confused by salt and tides, and marine scientists were more preoccupied by large open systems. Estuaries were merely regarded by each group as either river mouths or sea inlets respectively. For the past four decades, however, estuaries (and other transitional waters) have been regarded as being ecosystems in their own right. Although often not termed as such, this has led to paradigms being generated to summarise estuarine structure and functioning and which relate to both the natural science and management of these systems. This paper defines, details and affirms these paradigms that can be grouped into those covering firstly the science (definitions, scales, linkages, productivity, tolerances and variability) and secondly the management (pressures, valuation, health and services) of estuaries. The more ‘science’ orientated paradigms incorporate the development and types of ecotones, the nature of stressed and variable systems (with specific reference to resilience and redundancy), the relationship between generalists and specialists produced by environmental tolerance, the relevance of scale in relation to functioning and connectivity, the sources of production and degree of productivity, the biodiversity-ecosystem functioning and the stress-subsidy debates. The more ‘management’ targeted paradigms include the development and effects of exogenic unmanaged pressures and endogenic managed pressures, the perception of health and the ability to manage estuaries (related to internal and external influences), and the influence of all of these on the production of ecosystem services and societal benefits. 相似文献
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选取与生物神经元的工作过程较为相似的整合-激发(IF)神经元模型作为传递函数,建立了一个基于整合-激发(IF)神经元的新型自组织特征映射(SOM)网络。通过仿真验证了IF神经元网络的自组织功能,实现对传统自组织网的改进。 相似文献
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Multiple hypotheses have emerged to explain the apparent paradox of high diversity of the deep‐sea benthos when the environmental conditions are often predicted to inhibit rather than promote diversity. Many fundamental facets of these paradigms remain incompletely understood despite being central to understanding how deep‐sea ecosystems, and more generally all ecosystems, function. Here, we examine nine major paradigms of deep‐sea diversity that deserve, in our opinion, a fresh research impetus. We purposely challenge many of these ideas to generate dialogue and encourage further research. Some of the axiomatic predictions of these paradigms are: (i) the deep sea is highly diverse; (ii) stable environments reduce competition; (iii) species have finely partitioned niches; (iv) biological cropping promotes diversity; (v) disturbance controls diversity; (vi) patch mosaics structure assemblages; (vii) productivity controls diversity; (viii) recovery from disturbance is slow; and (ix) the deep sea is notoriously under‐sampled. We critically examine the evidence for each of these predictions and highlight areas where knowledge gaps exist and linkages to general ecological theory should occur. We conclude each section with ideas about questions and hypotheses that may fruitfully be tackled in future projects. 相似文献
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The response characteristics of conductivity-temperature-depth (CTD) sensors used for the derivation of ocean properties from profiling instruments are discussed. The influence of design and operating conditions on the impulse response is explored with examples drawn from commercially produced cells in common use. The speed dependence of both temperature and conductivity sensor response is discussed with reference to sensor matching to reduce salinity spiking. A brief discussion is included on data processing and filtering techniques 相似文献
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Seok Lee Heung-Jae Lie Kyu-Min Song Cheol-Ho Cho Eun-Pyo Lim 《Journal of Oceanography》2008,64(5):763-776
This study examined tidal modification and change in tidal currents caused by the construction of the Saemangeum dike, based
on field observations and a numerical model. The Saemangeum dike was completed in April 2006, enclosing an estuarine area
along the mid-western coast of South Korea. After closure of the dike, the tidal range outside the dike decreased slightly
but significantly, while the inside tidal range decreased drastically. The numerical model results show that the dike construction
has influenced tidal energy propagation and the tidal system in the Yellow Sea. The tidal current speed near the dike decreased
abruptly following closure of the dike, except in front of the sluice gates. Since completion of the dike, outflow water discharged
from the sluice gates has longer residence times due to the weakened tidal current; the change in the tidal current field
has also caused greater northward expansion of outflow water. The sluice gates release fresher water, which spreads over the
sea surface mainly by inertial momentum near the gate; this water is then gradually mixed with sea water farther from the
gate. The less saline, possibly more contaminated outflow impacts the marine environment near the Saemangeum dike. Controlling
the discharge and gate-opening timing can partially mitigate these impacts on the marine environment. 相似文献