Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126     

Kei Nakayama  Naomi Sei  Yuji Oshima  Kosuke Tashiro  Yohei Shimasaki  Tsuneo Honjo 《Marine pollution bulletin》2008,57(6-12):460

Polychlorinated biphenyls (PCBs) are known as neurotoxic chemicals and possibly alter animal behavior. We previously reported that PCB-exposure induced abnormal schooling behavior in Japanese medaka (Oryzias latipes). This abnormal behavior might be caused by the functional alteration of central or terminal nervous system. To understand the mechanism(s) of behavioral change by PCB-exposure, we analyzed the gene expression profiles in the brain of medaka exposed to 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) or a PCB mixture (Kanechlor-400: KC-400) using a cDNA microarray that we constructed. Twelve FLF-II strain medaka (six individuals per treatment) were dietary exposed to PCB126 (0.01 μg/g b.w./day) or KC-400 (1 μg/g b.w./day) for three weeks. For the control, six fish were fed a control diet. After the exposure period, fish were dissected, and the brain samples were collected. The samples from control fish were pooled and used as a common reference in the microarray experiment. Microarray data were normalized by the LOWESS method, and we screened the genes whose expression levels were altered more than 1.5-fold. Gene expression profiling showed 97 down-regulated and 379 up-regulated genes in the brain of medaka exposed to PCB126. KC-400 exposure suppressed 15 genes and induced 266 genes in medaka brain. Among these genes, the expression levels of 7 and 188 genes were commonly down- or up-regulated, respectively in both treatment groups. On the other hand, 31 gene expressions were significantly different between PCB126 and KC-400 treatment groups, and three out of 31 genes were received opposite effects. In addition, the microarray data showed that thyroid hormone-responsive genes were up-regulated by PCB-exposure, which may imply that PCBs or their metabolites mimic thyroid hormone effects in the brain of PCB-exposed medaka.  相似文献   

Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126     

Nakayama K  Sei N  Oshima Y  Tashiro K  Shimasaki Y  Honjo T 《Marine pollution bulletin》2008,57(6-12):460-466

Polychlorinated biphenyls (PCBs) are known as neurotoxic chemicals and possibly alter animal behavior. We previously reported that PCB-exposure induced abnormal schooling behavior in Japanese medaka (Oryzias latipes). This abnormal behavior might be caused by the functional alteration of central or terminal nervous system. To understand the mechanism(s) of behavioral change by PCB-exposure, we analyzed the gene expression profiles in the brain of medaka exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or a PCB mixture (Kanechlor-400: KC-400) using a cDNA microarray that we constructed. Twelve FLF-II strain medaka (six individuals per treatment) were dietary exposed to PCB126 (0.01 microg/g b.w./day) or KC-400 (1 microg/g b.w./day) for three weeks. For the control, six fish were fed a control diet. After the exposure period, fish were dissected, and the brain samples were collected. The samples from control fish were pooled and used as a common reference in the microarray experiment. Microarray data were normalized by the LOWESS method, and we screened the genes whose expression levels were altered more than 1.5-fold. Gene expression profiling showed 97 down-regulated and 379 up-regulated genes in the brain of medaka exposed to PCB126. KC-400 exposure suppressed 15 genes and induced 266 genes in medaka brain. Among these genes, the expression levels of 7 and 188 genes were commonly down- or up-regulated, respectively in both treatment groups. On the other hand, 31 gene expressions were significantly different between PCB126 and KC-400 treatment groups, and three out of 31 genes were received opposite effects. In addition, the microarray data showed that thyroid hormone-responsive genes were up-regulated by PCB-exposure, which may imply that PCBs or their metabolites mimic thyroid hormone effects in the brain of PCB-exposed medaka.  相似文献   

Electrical conductivities of pyrolitic mantle and MORB materials up to the lowermost mantle conditions     

Kenji Ohta  Kei Hirose  Masahiro Ichiki  Katsuya Shimizu  Nagayoshi Sata  Yasuo Ohishi 《Earth and Planetary Science Letters》2010,289(3-4):497-502

The electrical conductivities of natural pyrolitic mantle and MORB materials were measured at high pressure and temperature covering the entire lower mantle conditions up to 133 GPa and 2650 K. In contrast to the previous laboratory-based models, our data demonstrate that the conductivity of pyrolite does not increase monotonically but varies dramatically with depth in the lower mantle; it drops due to high-spin to low-spin transition of iron in both perovskite and ferropericlase in the mid-lower mantle and increases sharply across the perovskite to post-perovskite phase transition at the D″ layer. We also found that the MORB exhibits much higher conductivity than pyrolite. The depth–conductivity profile measured for pyrolite does not match the geomagnetic field data below about 1500-km depth, possibly suggesting the existence of large quantities of subducted MORB crust in the deep lower mantle. The observations of geomagnetic jerks suggest that the electrical conductivity may be laterally heterogeneous in the lowermost mantle with high anomaly underneath Africa and the Pacific, the same regions as large low shear-wave velocity provinces. Such conductivity and shear-wave speed anomalies are also possibly caused by the deep subduction and accumulation of dense MORB crust above the core–mantle boundary.  相似文献   

Development of an operational coastal model of the Seto Inland Sea,Japan     

Kei Sakamoto  Goro Yamanaka  Hiroyuki Tsujino  Hideyuki Nakano  Shogo Urakawa  Norihisa Usui  Mikitoshi Hirabara  Koji Ogawa 《Ocean Dynamics》2016,66(1):77-97

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Gravitational wave background from neutrino-driven gamma-ray bursts     

Takashi Hiramatsu  Kei Kotake  Hideaki Kudoh  Atsushi Taruya 《Monthly notices of the Royal Astronomical Society》2005,364(3):1063-1068

We study cosmic microwave background (CMB) secondary anisotropies produced by inhomogeneous reionization by means of cosmological simulations coupled with the radiative transfer code crash . The reionization history is consistent with the Wilkinson Microwave Anisotropy Probe Thomson optical depth determination. We find that the signal arising from this process dominates over the primary CMB component for   l ≳ 4000  and reaches a maximum amplitude of   l ( l + 1) C_l /2π≃ 1.6 × 10⁻¹³  on arcmin scales (i.e. l as large as several thousands). We then cross-correlate secondary CMB anisotropy maps with neutral hydrogen 21-cm line emission fluctuations obtained from the same simulations. The two signals are highly anticorrelated on angular scales corresponding to the typical size of H  ii regions (including overlapping) at the 21-cm map redshift. We show how the CMB/21-cm cross-correlation can be used: (i) to study the nature of the reionization sources; (ii) to reconstruct the cosmic reionization history; (iii) to infer the mean cosmic ionization level at any redshift. We discuss the feasibility of the proposed experiment with forthcoming facilities.  相似文献   

Discussion of landslide self‐organized criticality and the initiation of debris flow     

Chen Chien‐Yuan  Yu Fan‐Chieh  Lin Sheng‐Chi  Cheung Kei‐Wai 《地球表面变化过程与地形》2007,32(2):197-209

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Space weathered rims found on the surfaces of the Itokawa dust particles     

Takaaki Noguchi  Makoto Kimura  Takahito Hashimoto  Mitsuru Konno  Tomoki Nakamura  Michael E. Zolensky  Ryuji Okazaki  Masahiko Tanaka  Akira Tsuchiyama  Aiko Nakato  Toshinori Ogami  Hatsumi Ishida  Ryosuke Sagae  Shinichi Tsujimoto  Toru Matsumoto  Junya Matsuno  Akio Fujimura  Masanao Abe  Toru Yada  Toshifumi Mukai  Munetaka Ueno  Tatsuaki Okada  Kei Shirai  Yukihiro Ishibashi 《Meteoritics & planetary science》2014,49(2):188-214

On the basis of observations using Cs‐corrected STEM, we identified three types of surface modification probably formed by space weathering on the surfaces of Itokawa particles. They are (1) redeposition rims (2–3 nm), (2) composite rims (30–60 nm), and (3) composite vesicular rims (60–80 nm). These rims are characterized by a combination of three zones. Zone I occupies the outermost part of the surface modification, which contains elements that are not included in the unchanged substrate minerals, suggesting that this zone is composed of sputter deposits and/or impact vapor deposits originating from the surrounding minerals. Redeposition rims are composed only of Zone I and directly attaches to the unchanged minerals (Zone III). Zone I of composite and composite vesicular rims often contains nanophase (Fe,Mg)S. The composite rims and the composite vesicular rims have a two‐layered structure: a combination of Zone I and Zone II, below which Zone III exists. Zone II is the partially amorphized zone. Zone II of ferromagnesian silicates contains abundant nanophase Fe. Radiation‐induced segregation and in situ reduction are the most plausible mechanisms to form nanophase Fe in Zone II. Their lattice fringes indicate that they contain metallic iron, which probably causes the reddening of the reflectance spectra of Itokawa. Zone II of the composite vesicular rims contains vesicles. The vesicles in Zone II were probably formed by segregation of solar wind He implanted in this zone. The textures strongly suggest that solar wind irradiation damage and implantation are the major causes of surface modification and space weathering on Itokawa.  相似文献   

Mineral chemistry of MUSES‐C Regio inferred from analysis of dust particles collected from the first‐ and second‐touchdown sites on asteroid Itokawa     

Tomoki Nakamura  Aiko Nakato  Hatsumi Ishida  Shigeru Wakita  Takaaki Noguchi  Michael E. Zolensky  Masahiko Tanaka  Makoto Kimura  Akira Tshuchiyama  Toshihiro Ogami  Takahito Hashimoto  Mitsuru Konno  Masayuki Uesugi  Toru Yada  Kei Shirai  Akio Fujimura  Ryuji Okazaki  Scott. A. Sandford  Yukihiro Ishibashi  Masanao Abe  Tatsuaki Okada  Munetaka Ueno  Junichiro Kawaguchi 《Meteoritics & planetary science》2014,49(2):215-227

The mineralogy and mineral chemistry of Itokawa dust particles captured during the first and second touchdowns on the MUSES‐C Regio were characterized by synchrotron‐radiation X‐ray diffraction and field‐emission electron microprobe analysis. Olivine and low‐ and high‐Ca pyroxene, plagioclase, and merrillite compositions of the first‐touchdown particles are similar to those of the second‐touchdown particles. The two touchdown sites are separated by approximately 100 meters and therefore the similarity suggests that MUSES‐C Regio is covered with dust particles of uniform mineral chemistry of LL chondrites. Quantitative compositional properties of 48 dust particles, including both first‐ and second‐touchdown samples, indicate that dust particles of MUSES‐C Regio have experienced prolonged thermal metamorphism, but they are not fully equilibrated in terms of chemical composition. This suggests that MUSES‐C particles were heated in a single asteroid at different temperatures. During slow cooling from a peak temperature of approximately 800 °C, chemical compositions of plagioclase and K‐feldspar seem to have been modified: Ab and Or contents changed during cooling, but An did not. This compositional modification is reproduced by a numerical simulation that modeled the cooling process of a 50 km sized Itokawa parent asteroid. After cooling, some particles have been heavily impacted and heated, which resulted in heterogeneous distributions of Na and K within plagioclase crystals. Impact‐induced chemical modification of plagioclase was verified by a comparison to a shock vein in the Kilabo LL6 ordinary chondrite where Na‐K distributions of plagioclase have been disturbed.  相似文献   

Winter precipitation isotope slopes of the contiguous USA and their relationship to the Pacific/North American (PNA) pattern   总被引：1，自引：0，他引：1  

Zhongfang Liu  Gabriel J. Bowen  Jeffrey M. Welker  Kei Yoshimura 《Climate Dynamics》2013,41(2):403-420

This study compares the synoptic-dynamic relationship between two phases of the Pacific/North American (PNA) pattern and winter precipitation isotopes at 73 sites across the contiguous USA. We use the spatial pattern of isotope slope—the rate of changes in precipitation isotope ratios with distance—to identify features in the seasonal precipitation isotope fields related to climatic patterns, PNA positive and PNA negative. Our results show relationships between zones of high isotope slopes and the spatial position of the polar jet stream and juxtaposition of air masses associated with the PNA pattern. During a positive PNA winter, zones of high isotope slope in the eastern USA shift southward. This change is coincident with a southward displacement of the polar jet stream in this region, which leads to a greater frequency of polar air masses and ¹⁸O-depleted isotope values of precipitation in the region. In the western USA, zones of high slope shift eastward during the positive PNA winter, associated with more frequent penetration of tropical air masses that bring ¹⁸O-enriched precipitation to the region. Differences in δ¹⁸O/temperature relationships between the PNA-positive and -negative winters and contrasting δ¹⁸O/temperature behaviors in the eastern and western USA provide support for the role of variation in moisture source and transport as a control on the isotopic patterns. These findings highlight the importance of synoptic climate driven by PNA pattern in determining the spatial patterns of precipitation isotopes and provide constraints on paleo-water isotope interpretation and modern isotope hydrological processes.  相似文献   

Development of a new operational system for monitoring and forecasting coastal and open-ocean states around Japan     

Hirose  Nariaki  Usui  Norihisa  Sakamoto  Kei  Tsujino  Hiroyuki  Yamanaka  Goro  Nakano  Hideyuki  Urakawa  Shogo  Toyoda  Takahiro  Fujii  Yosuke  Kohno  Nadao 《Ocean Dynamics》2019,69(11):1333-1357

We developed a new system to monitor and forecast coastal and open-ocean states around Japan for operational use by the Japan Meteorological Agency. The system consists of an eddy-resolving analysis model based on four-dimensional variational assimilation and a high (2-km) resolution forecast model covering Japanese coastal areas that incorporates an initialization scheme with temporal and spatial filtering. Assimilation and forecast experiments were performed for 2008 to 2017, and the results were validated against various observation datasets. The assimilation results captured well the observed variability in sea surface temperature, coastal sea level, volume transport, and sea ice. Furthermore, the volume budget for the Japan Sea was significantly improved by the use of the 2-km resolution forecast model compared with the 10-km resolution analysis model. The forecast results indicate that this system has a predictive limit longer than 1 month in many areas, including in the Kuroshio current area south of Japan and the southern Japan Sea. In the forecast results of case studies, the 2017 Kuroshio large meander was well predicted, and warm water intrusions accompanying Kuroshio path variations south of Japan were also successfully reproduced. Sea ice forecasts for the Sea of Okhotsk largely captured the evolution of sea ice in late winter, but sea ice in early winter included relatively large errors. This system has high potential to meet operational requirements for monitoring and forecasting ocean phenomena at both meso- and coastal scales.

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