Production of the Blood Pressure Lowing Peptides from Brown Alga （ Undaria pinnatifida ）     

Sato Minoru Oba Takashi Hosokawa Takao Yamaguchi Toshiyasu Nakano Toshiki Saito Tadao Muramoto Koji Kahara T akashi Funayama Katsura Kobayashi Akio Nakano Takahisa 《中国海洋大学学报(英文版)》2005,4(3):209-213

Brown alga （ Undaria pinnatifida） was treated with alginate lyase and hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme （ACE） was measured. Four hydrolysates with potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats （SHRs）. The systolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by pro- tease S ＇ Amano＇ （from Bacillus stearothermophilus） at the concentration of 10 （mg protein） （kg body weight）^ - 1. In the 17 weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10 weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressed for 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction and HPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid composition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, and Leu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. The brown alga hydrolysates were also confirmed to decrease the blood pressure in humans.  相似文献   

Notes on non-marine bivalve Trigonioides (Trigonioides?) from the mid-Cretaceous Goshoura Group, Kyushu, Japan     

Toshifumi Komatsu  Chen Jinhua  Hiroaki Ugai  Koji Hirose 《Journal of Asian Earth Sciences》2007,29(5-6):795-802

Trigonioides goshourensis n. sp. and Trigonioides amakusensis Kikuchi and Tashiro occur in the late Albian Eboshi Formation of the Goshoura Group in Kyushu, Japan. These Albian species are characterized by three radial pseudocardinal teeth on the thick and wide hinge plate, and are probably ancestors of Cenomanian species of Trigonioides (Kumamotoa) with four radial pseudocardinal teeth. This chronological relation may be important for the correlation of non-marine Cretaceous strata in East Asia. In addition, the habitat of T. amakusensis is interpreted as estuarine tidal flats under brackish water conditions, although Trigonioides is generally a freshwater bivalve genus.  相似文献   

New radioisotope-free method for measuring bacterial production using [15N5]-2′-deoxyadenosine and liquid chromatography mass spectrometry (LC–MS) in aquatic environments     

Kenji Tsuchiya  Tomoharu Sano  Nobuyuki Kawasaki  Hideki Fukuda  Noriko Tomioka  Koji Hamasaki  Yuya Tada  Shinji Shimode  Tatsuki Toda  Akio Imai 《Journal of Oceanography》2015,71(6):675-683

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Seasonal barotropic sea surface height fluctuation in relation to regional ocean mass variation     

Tsurane Kuragano  Yosuke Fujii  Takahiro Toyoda  Norihisa Usui  Koji Ogawa  Masafumi Kamachi 《Journal of Oceanography》2014,70(1):45-62

A consistency between seasonal fluctuation of actual sea surface height (SSH) and those caused by mass and density variations in gyre-scale regions is examined. The SSH obtained from satellite altimetry (altimetric SSH) is adopted as the actual SSH. SSH caused by mass variation (mass-related SSH) is simulated using a barotropic global ocean model forced by water flux, wind stress and surface pressure. SSH caused by density variation (steric SSH) is calculated from water density profile, i.e. temperature and salinity profiles. The model SSH well represents mass-related SSH for gyre-scale regional means, and seasonal fluctuation of the altimetric SSH corrected for the model SSH is similar to that of steric SSH above a pressure level larger than 300 dbar. The results indicate that the mass-related SSH does not much respond to the baroclinic adjustment to the seasonally varying wind stress curl. The mass-related SSH forced by wind stress and surface pressure should be accounted for regional evaluation, though it is not necessary for global mean evaluation. Detection of steric SSH from altimetric SSH would be useful for assimilation approaches in which the altimetric SSH is treated as the variable reflecting subsurface temperature and salinity.  相似文献   

Biotic response of benthic foraminifera in Aso-kai lagoon,central Japan,to changes in terrestrial climate and ocean conditions (~AD 700–1600)     

Hiroyuki Takata  Satoshi Tanaka  Koji Seto  Saburo Sakai  Katsumi Takayasu  Boo-Keun Khim 《Journal of Paleolimnology》2014,51(3):421-435

We investigated responses of shallow-water benthic foraminifera to changes in climate and ocean conditions, using sediment core ASC2 from Aso-kai lagoon, central Japan. Six AMS ¹⁴C dates reveal that the studied interval corresponds to sediments deposited from ~AD 700 to 1600. Sulfur content of the bulk sediment and multi-dimensional scaling (MDS) axis 1 of fossil benthic foraminifera indicate that the composition of the benthic foraminifera community was closely related to dissolved oxygen (DO) concentration in the hypolimnion. The sulfur content and MDS axis 1 also revealed two shifts over the 900-year interval. In the first phase (~AD 700–1250), the Shannon–Wiener Index (H′), E (S₂₀₀), evenness and rank abundance curve (RAC) kurtosis indicate a gradual deterioration in structure of the benthic foraminifera community. In that period, there are statistically significant correlations between the faunal composition (MDS axis 1) and faunal structure [Shannon–Wiener (H′), E (S₂₀₀), evenness and RAC kurtosis]. In the second phase (~AD 1250–1600), however, faunal composition and structure show no marked correspondence. Instead, abundance of benthic foraminifera fluctuated on a scale of ~200 years. Thus, a shift in the biotic response of benthic foraminifera in Aso-kai lagoon occurred in ca. AD 1250. Gradual deterioration of benthic foraminifera, with taxonomic losses, is consistent with declining DO in the first phase, possibly associated with the increasing influence of the Tsushima Warm Current. The possibility that closure of Aso-kai lagoon and development of the sand bar affected benthic foraminifera cannot, however, be ruled out. No corresponding response was observed in the second phase, during which there was no distinct taxonomic loss. Large variations in abundance, however, were a consequence of strength of the East Asian summer and winter monsoons. The shift in the biotic response of benthic foraminifera in Aso-kai lagoon during the period AD 700–1600 was apparently a result of changes in climate and ocean conditions on the East Asian continental margin.  相似文献   

Climatic impacts on crop yield and its variability in Nepal: do they vary across seasons and altitudes?     

Santosh Poudel  Koji Kotani 《Climatic change》2013,116(2):327-355

A rapid change in climate patterns potentially driven by global warming is considered to be greatest threats to agriculture. However, little is known about how the change in climate concretely affects agricultural production especially in Nepal with respect to seasons and regions of different altitudes. To examine this issue, we seek to empirically identify the impact of climatic variation on agricultural yield and its variability by utilizing the data of rice, wheat and climate variables in the central region of Nepal. The main focus is on whether the impacts vary across seasons, altitudes and the types of crops. For this purpose, we employ a stochastic production function approach by controlling a novel set of season-wise climatic and geographical variables. The result shows that an increase in the variance of both temperature and rainfall has adverse effects on crop productions in general. On the other hand, a change in the mean levels of the temperature and rainfall induces heterogeneous impacts, which can be considered beneficial, harmful or negligible, depending on the altitudes and the kinds of crops. These results imply that adaptation strategies must be tailor-made in Nepalese agriculture, considering growing seasons, altitudes and the types of crops.  相似文献   

Application of numerical method of dynamical oceanography     

Koji Hidaka 《Journal of Oceanography》1970,26(4):237-241

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Tectonic shortening and coeval volcanism during the Quaternary, Northeast Japan arc     

Koji Umeda  Masao Ban  Shintaro Hayashi  Tomohiro Kusano 《Journal of Earth System Science》2013,122(1):137-147

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Land cover monitoring in Asia by NOAA GVI data     

Ryutaro Tateishi  Koji Kajiwara 《国际地球制图》2013,28(4):53-64

NOAA/AVHRR Global Vegetation Index (GVI) data of Asia in 1983 and 1987 were used to evaluate their usefulness for global land cover monitoring. Color composite images of monthly GVI data and color composite images of principal components from 12 successive monthly GVI data were found to be useful for visual interpretation of seasonal vegetation dynamics. The results of cluster analysis applied to monthly GVI data for a one‐year period, indicate that unsupervised classification method is useful for global or continental land cover classification without ground truth. In order to detect land cover changes, the difference between the 1983 and 1987 12‐month GVI data was calculated. The results show that it is difficult to detect land cover changes due to cloud contamination in monthly GVI data and poor registration of GVI products.  相似文献   

黑濑川地体源于亚洲大陆东缘何处？     

Shigeki HADA  Koji UNO  Kuniyuki FURUKAWA 《地球学报》2012,33(S1):12-14

The point at issue: The Kurosegawa Terrane is composed of continental fragments transecting Mesozoic terranes of accretionary complex in Southwest Japan (Fig. 1). It is an attenuated tectonic sliver and considered to be allochthonous with respect to the main part of Southwest Japan. The problem of which continental block in the East Asian continental margin is the source of the Kurosegawa Terrane has puzzled Japanese geologists for many years. Firstly, we try to approach this issue based on the analysis of fusulinacean assemblage in accreted terranes composed of subduction complex in the Pacific Rim. Secondly, by applying the result of this analysis we try to locate the source of the continental fragments of the Kurosegawa Terrane. Thirdly, we try to prove its validity with a new paleomagnetic study.  相似文献