参附注射液建立自发性高血压病大鼠肝阳上亢证模型的研究          下载免费PDF全文

周梦  杨文丽  刘晓庆 《应用海洋学学报》2018,34(12):120-122

目的：探讨参附注射液建立自发性高血压大鼠（SHR）模型的可能性。方法：将30只3月龄SPF级健康雄性自发性高血压大鼠称重，随机分为SHR组，附子汤组，参附注射液低、中、高剂量组，每组6只。各组采用对应药物灌胃进行模型制备，另取同品系同周龄雄性魏-凯二氏大鼠（WKY）6只作为正常对照组（WKY组）。观察参附注射液对SHR大鼠24h饮水量、易激惹程度、痛阈、睑结膜充血及收缩压的影响。结果：附子汤组及参附注射液中、高剂量组造模后均出现了易激惹程度增高、睑结膜充血程度增高、饮水量增多、痛阈降低、收缩压升高等肝阳上亢的表现，与WKY组及SHR组比较，差异有统计学意义（P<0.05)，表明造模成功。结论：参附注射液可以制备新型高血压肝阳上亢证模型，但是具体造模机制以及造模药物用量需待进一步探讨确定。  相似文献   

广州城市流浪乞讨者的空间管治与日常生活实践   总被引：2，自引：0，他引：2  

尹铎  蔡慕言  梁金多  朱竑  高权 《地理科学》2019,39(3):450-458

以广州流浪乞讨者为研究对象,通过深度访谈等质性研究方法,解读针对流浪乞讨者的空间管治政策与手段,分析流浪乞讨者的日常生活实践与生境协商。研究发现：在地方城市政策对流动性与公共秩序限制的双重压力下,在流浪乞讨者的日常生活实践中,不仅有针对管治行动者而刻意为之的特殊营建,亦有基于程式化生活流程对自我身份认同的重塑与真情实感的展演。地方政府基于空间目标的救助与真实存在的日常生活实践存在着一种张力。研究关注了城市边缘群体日常生活对地理意义的主动塑造过程,对全面理解并规范管理中国城市流浪乞讨现象具有借鉴意义。  相似文献   

Bibliometric Analysis of Global Research Progress on Coastal Flooding 1995–2016     

Chao Gao  Tian Ruan 《中国地理科学(英文版)》2018,28(6):998-1008

Global research progress on coastal flooding was studied using a bibliometric evaluation of publications listed in the Web of Science extended scientific citation index. There was substantial growth in coastal flooding research output, with increasing publications, a higher collaboration index, and more references during the 1995–2016 period. The USA has taken a dominant position in coastal flooding research, with the US Geological Survey leading the publications ranking. Research collaborations at institutional scales have become more important than those at global scales. International collaborative publications consistently drew more citations than those from a single country. Furthermore, coastal flooding research included combinations of multi-disciplinary categories, including ‘Geology' and ‘Environmental Sciences Ecology'. The most important coastal flooding research sites were wetlands and estuaries. While numerical modeling and 3 S(Remote sensing, RS; Geography information systems, GIS; Global positioning systems, GPS) technology were the most commonly used methods for studying coastal flooding, Lidar gained in popularity. The vulnerability and adaptation of coastal environments, their resilience after flooding, and ecosystem services function showed increases in interest.  相似文献   

风和径流量对长江口缺氧影响的数值模拟   总被引：1，自引：1，他引：0  

郑静静  刘桂梅  高姗  李云  李志杰 《海洋学报》2018,40(9):1-17

受自然和人类活动的影响，海洋缺氧现象日益严重，威胁着海洋生态环境，海洋缺氧问题已经引起了人们的广泛关注。本文应用区域海洋模式并耦合生态模式，对东海的生态系统进行了数值模拟和分析研究。与观测数据比较显示，该模型能较好地模拟长江口外生态变量的分布趋势。另外本文通过设置不同敏感性实验，探讨风和径流量对长江口底层缺氧现象的影响，结果分析表明，风和径流量对长江口外缺氧区的形成有显著的影响。径流量变化虽然对长江口外缺氧区的季节变化影响并不显著，但是对缺氧区域面积却存在显著的影响。径流量增加，水体层化增强，表层叶绿素浓度增加，最终导致缺氧区域范围扩展；径流量减小，水体层化减弱，表层叶绿素浓度减小，缺氧区域范围缩小。风向和风速的改变不仅影响长江口外缺氧区的季节变化，还影响缺氧区域面积。  相似文献   

Implementation of a coupled plastic damage distinct lattice spring model for dynamic crack propagation in geomaterials          下载免费PDF全文

Chao Jiang  Gao‐Feng Zhao 《国际地质力学数值与分析法杂志》2018,42(4):674-693

This paper studies dynamic crack propagation by employing the distinct lattice spring model (DLSM) and 3‐dimensional (3D) printing technique. A damage‐plasticity model was developed and implemented in a 2D DLSM. Applicability of the damage‐plasticity DLSM was verified against analytical elastic solutions and experimental results for crack propagation. As a physical analogy, dynamic fracturing tests were conducted on 3D printed specimens using the split Hopkinson pressure bar. The dynamic stress intensity factors were recorded, and crack paths were captured by a high‐speed camera. A parametric study was conducted to find the influences of the parameters on cracking behaviors, including initial and peak fracture toughness, crack speed, and crack patterns. Finally, selection of parameters for the damage‐plasticity model was determined through the comparison of numerical predictions and the experimentally observed cracking features.  相似文献   

两株南极枝孢霉属真菌Cladosporium sp.NJF4和NJF6的次级代谢产物研究          下载免费PDF全文

常俊男  田晓清  樊成奇  黄金昌  陆亚男  韩清华 《极地研究》2020,32(1):60-67

南极因其独特的自然环境成为潜在、重要的微生物资源库,是产生新型生物活性物质和先导化合物菌株的潜在种源地,南极微生物正在成为创新药物研究新的重要资源。虽然近年来对南极微生物次级代谢产物的研究逐渐增加,但与温带和热带微生物研究相比仍处于初级阶段。对从南极普里兹湾海洋沉积物中获得的两株枝孢霉属真菌Cladosporium sp. NJF4和NJF6进行次级代谢产物分离及结构鉴定,获得20个化合物。化合物结构类型包括甾醇(1)、倍半萜类(7—8)、生物碱类(9—14)、二酮哌嗪(2—5、15—17)、芳香酸(6、18—19)等,其中倍半萜类(7—8)为首次从枝孢霉属真菌中分离得到,以上研究将为丰富南极微生物次级代谢产物库奠定一定的研究基础。  相似文献   

A machine learning approach for predicting computational intensity and domain decomposition in parallel geoprocessing     

Peng Yue  Fan Gao  Boyi Shangguan  Zheren Yan 《International journal of geographical information science》2020,34(11):2243-2274

ABSTRACT

High performance computing is required for fast geoprocessing of geospatial big data. Using spatial domains to represent computational intensity (CIT) and domain decomposition for parallelism are prominent strategies when designing parallel geoprocessing applications. Traditional domain decomposition is limited in evaluating the computational intensity, which often results in load imbalance and poor parallel performance. From the data science perspective, machine learning from Artificial Intelligence (AI) shows promise for better CIT evaluation. This paper proposes a machine learning approach for predicting computational intensity, followed by an optimized domain decomposition, which divides the spatial domain into balanced subdivisions based on the predicted CIT to achieve better parallel performance. The approach provides a reference framework on how various machine learning methods including feature selection and model training can be used in predicting computational intensity and optimizing parallel geoprocessing against different cases. Some comparative experiments between the approach and traditional methods were performed using the two cases, DEM generation from point clouds and spatial intersection on vector data. The results not only demonstrate the advantage of the approach, but also provide hints on how traditional GIS computation can be improved by the AI machine learning.  相似文献   

江汉盆地钻孔测井资料确定地应力最大水平主压应力方向     

高士钧  储昭坦 《大地测量与地球动力学》1997,(4)

利用钻孔测井资料并运用地层倾角测量信息分析法，给出了江汉盆地地应力最大水平主压应力方向为ＮＥ６０～６５°  相似文献   

DEVELOPMENT STRATEGIES OF WATER AND LAND RESOURCES IN THE HEXI REGION,CHINA     

肖洪浪  高前兆  李福兴 《中国地理科学(英文版)》1996,(1)

ＤＥＶＥＬＯＰＭＥＮＴＳＴＲＡＴＥＧＩＥＳＯＦＷＡＴＥＲＡＮＤＬＡＮＤＲＥＳＯＵＲＣＥＳＩＮＴＨＥＨＥＸＩＲＥＧＩＯＮ，ＣＨＩＮＡ肖洪浪，高前兆，李福兴ＤＥＶＥＬＯＰＭＥＮＴＳＴＲＡＴＥＧＩＥＳＯＦＷＡＴＥＲＡＮＤＬＡＮＤＲＥＳＯＵＲＣＥＳＩＮＴＨＥ...  相似文献   

法库地区大型韧性剪切带特征及成因机制     

杨晓波  高恩忆 《国土资源》1996,(2)

通过对辽北法库地区构造岩的观察和研究，确定了本区存在一大型推覆韧性剪切带。根据同构造侵入岩的同位素年龄，确定该韧性剪切带形成时期为海西－印支期，这与天山－兴安褶皱系最终形成时间相一致  相似文献