Effects of sulfate chitosan derivatives on nonalcoholic fatty liver disease     

Mingming Yu  Yuanhong Wang  Tingfu Jiang  Zhihua Lv 《中国海洋大学学报(英文版)》2014,13(3):531-537

Sulfate chitosan derivatives have good solubility and therapeutic effect on the cell model of NAFLD. The aim of this study was to examine the therapeutic effect of sulfate chitosan derivatives on NAFLD. The male Wistar rats were orally fed high fat emulsion and received sulfate chitosan derivatives for 5 weeks to determine the pre-treatment effect of sulfate chitosan derivatives on NAFLD. To evaluate the therapeutic effect of sulfate chitosan derivatives on NAFLD, the rats were orally fed with high concentration emulsion for 5 weeks, followed by sulfate chitosan derivatives for 3 weeks. Histological analysis and biomedical assays showed that sulfate chitosan derivatives can dramatically prevent the development of hepatic steatosis in hepatocyte cells. In animal studies, pre-treatment and treatment with sulfate chitosan derivatives significantly protected against hepatic steatohepatitis induced by high fat diet according to histological analysis. Furthermore, increased TC, ALT, MDA, and LEP in NAFLD were significantly ameliorated by pre-treatment and treatment with sulfate chitosan derivatives. Furthermore, increased TG, AST, and TNF-α in NAFLD were significantly ameliorated by treatment with sulfate chitosan derivatives. Sulfate chitosan derivatives have good pre-treatment and therapeutic effect on NAFLD.  相似文献   

基于ICESat-2 ATLAS数据的DEM高程精度评价     

丁夏萌  张继贤  郭婧  张鹤  常亚茹 《测绘通报》2022,(12):84-90

为探究ASTER GDEMV3、SRTM1 DEM和AW3D30 DEM 3种开源DEM数据的高程精度,本文以高精度ICESat-2 ATLAS测高数据为参考数据,利用GIS统计分析、误差相关分析及数理统计对DEM的高程精度进行对比评价。结果表明：①AW3D30的质量最稳定;SRTM1 DEM在平原精度最高;在高原山地精度由高到低依次为AW3D30 DEM、ASTER GDEMV3、SRTM1 DEM。②DEM数据高程精度受地表覆盖影响较大,且与地形因素密切相关,在相同地表覆盖的两个研究区中DEM数据高程精度表现情况不一致,SRTM在平原地表覆盖下精度表现最好,平均误差为3.15 m,AW3D30 DEM在山地地表覆盖下精度表现最好,平均误差为7.61 m。③坡度对DEM数据的高程精度影响较大,在两个研究区3种DEM数据的高程误差均随坡度的增加而增加;坡向对DEM数据的高程精度影响较小,未发现明显的规律。  相似文献   

Controlling Factors,Accumulation Model and Target Zone Prediction of the Coal‐bed Methane in the Huanghebei Coalfield,North China     

Dawei Lv  Jitao Chen  Zengxue Li  Guiqiang Zheng  Cuiyu Song  Haiyan Liu  Yanru Meng  Dongdong Wang 《Resource Geology》2014,64(4):332-345

The Huanghebei Coalfield, one of the coal production bases in North China, was considered as a coalfield without coal‐bed methane (CBM) during past decades. In recent years, however, CBM has been discovered in coal‐bearing successions. In order to understand the CBM geological characteristics and accumulation process in this area, fifteen coal samples were collected and analyzed with respect to coal maceral and reflectance. The result shows that the gas distribution is uneven and the content varies in different areas even for the same coal bed. The storage of CBM is affected by geological factors such as burial depth, geological structures, and magmatic intrusion, among which the former two are more important in the formation of CBM. Deep burial of coal beds with the presence of cap‐rock mudstone can seal CBM. The CBM is also accumulated and preserved at the place where normal faults are distributed. Magmatic intrusion causes contact metamorphism and controls the CBM formation by heating the coal‐bearing successions. The obtained data indicate the geological conditions in northeastern Zhaoguan Mine are preferable for CBM formation and conservation; recent exploration estimates the CBM geological reserves up to 282.16 Mm³ and average of reserve abundance at 0.1662 × 10⁸ m³ km^?2. The Changqing Mine is a potential prospect in terms of CBM exploration since its geological conditions (structures and burial depth) are similar to the Zhaoguan Mine and its cap rock is even better.  相似文献   

Epidemiological study on the relationship between the environmental pollution and lung cancer in high lung cancer incidence areas,China     

Linlin Zhang  Jungang Lv 《Environmental Earth Sciences》2014,71(11):4761-4766

Xuanwei and Fuyuan, two counties located in southwest China, are areas with exceptionally high lung cancer incidence since the 1970s. In this study, questionnaires from a total of 18 communes, and 28 administrative villages (consisting of 280 small villages) in the two counties were fulfilled and collected. The sampling sites were randomly chosen in consideration of the incidence rate of lung cancer and the types of coal used. The sampling sites were divided into high lung cancer occurrence areas and low lung cancer occurrence areas. Industrial and environmental information was investigated and finally analyzed for the possible relationship to the lung cancer. It indicated that 78.1 % of the villages in high lung cancer incidence areas had been found using smoky coal or coking coals in people’s everyday lives; 43.4 % of these villages located near the coking factories, 31.1 % near the iron-zinc smelters and 11.8 % near the chemical industries. In the low lung cancer incidence areas, 78.8 % of the villages had been found using non-smoky coals (anthracite) in people’s everyday lives; 26.9 % of these villages are near the coking factories, 23.1 % near the iron-zinc smelters and 5.8 % near the chemical industries. Logistic regression analysis indicated that the coal type used was a foremost risk factor related to incidence of lung cancer [β > 0, Exp (β) >1, P < 0.05]. The use of smoky coals and coking coals seemed to be a hazardous factor for lung cancer generation, while non-smoky coals seemed to have no significant relationship to the lung cancer incidence. The results in this study added basic and important data and should be helpful for the future study on the etiology of lung cancer.  相似文献   

Economic benefit assessment of the geo-hazard monitoring and warning engineering system in the Three Gorges Reservoir area: a case study of the landslide in Zigui     

Yu  Shiwei  Hou  Jindong  Lv  Jun  Ba  Guizhi 《Natural Hazards》2014,75(2):219-231

The completion and operation of the Three Gorges Reservoir in China have increased the frequency of geo-hazards and dangers in the area. To monitor and to warn of geo-hazards effectively, the Chinese government has invested billions of funds for constructing a monitoring and warning engineering system. Similar to other social infrastructure investments, a reasonable assessment of investment returns is necessary. Therefore, this study proposes an economic benefit assessment model, which considers both the expected and the actual values. The economic benefit of the geo-hazard monitoring and warning engineering in the Three Gorges Reservoir areas is evaluated. Based on the engineering characteristics, the model reasonably defines the frontier of the input and output and adds the casualties and the losses of ecological environment into the economic benefit evaluation index system. A case study on the Zhangjiawan landslide in Guojiaba Town, Zigui County, was conducted. The evaluation results show that (1) land has the largest benefit in direct reductional loss (total of 56.7 %), while the largest indirect reductional losses of the hazard-bearing bodies are in agricultural production and ecological environment (total of 97.6 %); (2) the costs-to-expected return ratio of landslide monitoring and warning engineering is 1:280, whereas the cost-to-actual benefit ratio is 1:30; (3) the accumulation of relevant information and the public knowledge of geological disasters should be strengthened.

  相似文献   

Simulated impacts of irrigation on evapotranspiration in a strongly exploited region: a case study of the Haihe River basin,China          下载免费PDF全文

Huimin Lei  Dawen Yang  Hanbo Yang  Zaijian Yuan  Huafang Lv 《水文研究》2015,29(12):2704-2719

Irrigation is the major water supply for crop production in water‐limited regions. However, this important water component is usually neglected or simplified in hydrological modelling primarily because information concerning irrigation is notably difficult to collect. To assess real effects of irrigation on the simulation of evapotranspiration (ET) in water‐limited region, the Community Land Model version 4 was established over a typical semi‐humid agricultural basin in the northern China – the Haihe River basin. In the irrigated cropland, incorporating an irrigation scheme can enhance the simulated ET and improve the simulation of spatial variability of soil moisture content. We found that different configurations in the irrigation scheme do not cause significant differences in the simulated annual ET. However, simulated ET with simulated irrigation differs clearly from that with observed irrigation in mean annual magnitude, long‐term trend and spatial distribution. Once the irrigation scheme is well‐calibrated against observations, it reasonably reproduces the interannual variability of annual irrigation, when irrigation water management is relatively stable. More importantly, parameter calibration should be consistent with the configuration of the source of irrigation water. However, an irrigation scheme with a constant parameter value cannot capture the trend in the annual irrigation amount caused by abrupt changes in agricultural water management. Compared with different remotely sensed ET products, the enhancement in the simulated ET by irrigation is smaller than the differences among these products, and the trend in simulated ET with the observed irrigation cannot be captured correctly by the remotely sensed ET. Copyright © 2014 John Wiley & Sons, Ltd.  相似文献   

Excessive greenhouse gas emissions from wastewater treatment plants by using the chemical oxygen demand standard     

Zongqing LV  Xiaoyu SHAN  Xilin XIAO  Ruanhong CAI  Yao ZHANG  Nianzhi JIAO 《中国科学:地球科学(英文版)》2022,65(1):87-95

Chemical oxygen demand(COD)is widely used as an organic pollution indicator in wastewater treatment plants.Large amounts of organic matter are removed during treatment processes to meet environmental standards,and consequently,substantial greenhouse gases(GHGs)such as methane(CH₄)are released.However,the COD indicator covers a great amount of refractory organic matter that is not a pollutant and could be a potential carbon sink.Here,we collected and analysed COD data from 86 worldwide municipal wastewater treatment plants(WWTPs)and applied a model published by the Intergovernmental Panel on Climate Change to estimate the emission of CH₄ due to recalcitrant organic compound processing in China’s municipal wastewater treatment systems.Our results showed that the average contribution of refractory COD to total COD removal was55%in 86 WWTPs.The amount of CH₄ released from the treatment of recalcitrant organic matter in 2018 could have been as high as 38.22 million tons of carbon dioxide equivalent,which amounts to the annual carbon sequestered by China’s wetlands.This suggests that the use of COD as an indicator for organic pollution is undue and needs to be revised to reduce the emission of GHG.In fact,leaving nontoxic recalcitrant organic matter in the wastewater may create a significant carbon sink and will save energy during the treatment process,aiming at carbon neutrality in the wastewater treatment industry.  相似文献   

伊利石40Ar-39Ar年龄的统计分析与成藏期          下载免费PDF全文

王龙樟  王立云  李季  肖娇静  郭威  沈奥  徐乔  王娅茹 《地球科学》2022,47(2):479-489

为了确定鄂尔多斯盆地苏里格气田的成藏年代,通过提取砂岩储层中的黏土质填隙物,分离分级成 < 0.5、0.5~1.0、1.0~2.0μm的分样品,进行伊利石激光阶段加热40Ar-39Ar定年.等时线年龄是自生伊利石与碎屑伊利石的混合年龄.通过趋势分析和回归分析分别获得极小的趋势年龄和极小的回归年龄,该年龄比较接近自生伊利石年龄.测试结果表明,伊利石的等时线年龄介于160.9~232.0 Ma之间,为自生伊利石与碎屑伊利石的混合年龄.采用数理统计方法获得极小趋势年龄和极小回归年龄分别为151.7 Ma和152.4 Ma,该年龄比较接近自生伊利石年龄,代表了热流体活动和油气成藏时间.   相似文献   

湖北寒武系牛蹄塘组页岩气成藏条件与综合评价          下载免费PDF全文

刘早学  许露露  温雅茹  张焱林  罗凡  段轲  陈威  周向辉  文剑航 《地球科学》2022,47(5):1586-1603

牛蹄塘组是湖北省重要的海相页岩气层系之一,对其深入研究有助于预测资源潜力并指明勘探方向.利用露头及探井资料对区内牛蹄塘组的储层特征、资源潜力等进行了研究.结果表明,牛蹄塘组依据岩性组合可以分为一段和二段,鄂西宜昌?恩施、神农架西侧深水陆棚相以及鄂东南盆地边缘相富有机质页岩厚度大,TOC含量高,以硅质类页岩为主,页岩气成藏物质基础良好.气显较好的地区集中分布在鄂西黄陵背斜东南缘,分析认为较弱的变形、有效的顶底板和适中的热演化是牛蹄塘组页岩气富集成藏的关键.除宜昌局部地区具有勘探开发前景外,秭归、鹤峰等地区仍值得探索,鄂东南及鄂西北地区由于构造变形和岩浆活动强烈,保存条件极差,基本无页岩气勘探前景.   相似文献   

中亚造山带东南部晚古生代-早中生代地壳增生和古亚洲洋演化:来自内蒙古东南部林西-东乌旗地区岩浆岩的证据SCIEI北大核心CSCD     

刘建峰  李锦轶  赵硕  张进  郑荣国  张文龙  吕前露  郑培玺 《岩石学报》2022,(8):2181-2215

本文在系统收集内蒙古林西-东乌旗地区晚古生代-早中生代岩浆岩的年代学、岩石地球化学以及锆石Hf同位素资料基础上,通过分析岩浆岩岩石组合随时空的变化规律,并结合区域地质资料,探讨了中亚造山带东南部洋盆演化和地壳增生等重要地质问题。研究结果表明,二连浩特-贺根山蛇绿岩带南、北两侧晚古生代-早中生代岩浆岩在年代学上显示不同的活动期次,具有不同岩石组合和地球化学特征,指示它们分属于不同的构造岩浆岩带。蛇绿岩带以北晚泥盆世-中二叠世岩浆活动在时间上呈连续分布的特征,并在晚石炭-早二叠世时期达到活动峰值。火成岩构造组合分析表明,晚泥盆世-石炭纪和早-中二叠世岩浆活动分别与二连浩特-贺根山洋盆向乌里雅斯太大陆边缘之下的俯冲和洋盆闭合后俯冲板片断离引起的软流圈上涌造成的区域伸展背景有关。蛇绿岩带以南岩浆活动时间上呈现石炭纪、早-中二叠世、晚二叠世-三叠纪幕式分布特征,各期岩浆活动前锋有随时间向南迁移的趋势。这三期岩浆活动分别与古亚洲洋板片向宝力道岛弧之下的俯冲、板片后撤以及洋盆消失之后古板块的碰撞造山作用有关。锆石Hf同位素分析表明,中亚造山带东南部晚古生代至早中生代时期存在显著的地壳增生;其中二连浩特-贺根山蛇绿岩带以北表现为地壳的垂向增生,以南表现为地壳的侧向增生。  相似文献