Production of the Blood Pressure Lowing Peptides from Brown Alga （ Undaria pinnatifida ）     

Sato Minoru Oba Takashi Hosokawa Takao Yamaguchi Toshiyasu Nakano Toshiki Saito Tadao Muramoto Koji Kahara T akashi Funayama Katsura Kobayashi Akio Nakano Takahisa 《中国海洋大学学报(英文版)》2005,4(3):209-213

Brown alga （ Undaria pinnatifida） was treated with alginate lyase and hydrolyzed using 17 kinds of proteases and the inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme （ACE） was measured. Four hydrolysates with potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats （SHRs）. The systolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by pro- tease S ＇ Amano＇ （from Bacillus stearothermophilus） at the concentration of 10 （mg protein） （kg body weight）^ - 1. In the 17 weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10 weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressed for 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction and HPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid composition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, and Leu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. The brown alga hydrolysates were also confirmed to decrease the blood pressure in humans.  相似文献   

Morphodynamics of deltas under the influence of humans   总被引：8，自引：0，他引：8  

James P.M. Syvitski  Yoshiki Saito   《Global and Planetary Change》2007,57(3-4):261-282

A consistent database was established to characterize key environmental factors known to control delta morphology. The database includes the location, basin morphology, fluvial and sediment discharge to the deltas, delta morphology, ocean energy, and shelf depth reached by the sub-aqueous delta. Fifty-one deltas were selected to cover the global parameter range of rivers entering all major oceans and coastal seas. Seasonal satellite images of the deltas were processed (IKONOS, SPOT, LANDSAT, and MODIS). Predictive statistical relationships were obtained, suitable for hypothesis testing or to constrain/verify numerical models used to simulate the evolution of coastal systems. The area of a delta is best predicted from average discharge, the total sediment load feeding the delta, and the offshore accommodation space. The gradient of a delta plain, measured from the apex of the delta to the coast along the main channel, is best predicted with a ratio of sediment supply to sediment retention, sediment concentration used as a proxy of delta plain sedimentation, and mean water discharge. Widths of distributary channels form a lognormal distribution, with the cumulative width of the river mouths directly related to the maximum discharge, tidal and wave energy. The grain size of topset deposits scales with the river length. Hundreds of millions of people occupy deltas and human engineering is now a major influence on the growth and evolution of many deltas, through control of the flow path of distributary channels, and mitigation of the seasonal flood wave with concomitant change in the delivery of sediment load. More and more deltas are moving away from their pre-Anthropocene morphology, as influenced by pristine sediment supply and sediment dispersal.  相似文献   

Estimating groundwater storage changes in the Mississippi River basin (USA) using GRACE   总被引：7，自引：0，他引：7  

Matthew Rodell  Jianli Chen  Hiroko Kato  James S. Famiglietti  Joe Nigro  Clark R. Wilson 《Hydrogeology Journal》2007,15(1):159-166

Based on satellite observations of Earth’s time variable gravity field from the Gravity Recovery and Climate Experiment (GRACE), it is possible to derive variations in terrestrial water storage, which includes groundwater, soil moisture, and snow. Given auxiliary information on the latter two, one can estimate groundwater storage variations. GRACE may be the only hope for groundwater depletion assessments in data-poor regions of the world. In this study, soil moisture and snow were simulated by the Global Land Data Assimilation System (GLDAS) and used to isolate groundwater storage anomalies from GRACE water storage data for the Mississippi River basin and its four major sub-basins. Results were evaluated using water level records from 58 wells set in the unconfined aquifers of the basin. Uncertainty in the technique was also assessed. The GRACE-GLDAS estimates compared favorably with the well based time series for the Mississippi River basin and the two sub-basins that are larger than 900,000 km². The technique performed poorly for the two sub-basins that have areas of approximately 500,000 km². Continuing enhancement of the GRACE processing methods is likely to improve the skill of the technique in the future, while also increasing the temporal resolution.  相似文献   

Medium-scale traveling ionospheric disturbances observed by GPS receiver network in Japan: a short review   总被引：2，自引：0，他引：2  

Takuya Tsugawa  Nobuki Kotake  Yuichi Otsuka  Akinori Saito 《GPS Solutions》2007,11(2):139-144

Medium-scale traveling ionospheric disturbances (MSTID) are wave-like perturbations of the ionospheric plasma with wavelengths of several hundred kilometres and velocities of several hundred metres per second. MSTID is one of the most common ionospheric phenomena that generally induce the perturbations of ionospheric total electron content (TEC) by ∼10¹⁶ electron/m², which corresponds to ∼54 ns (16.2 cm) delay at GPS L1 signal. In the past decade, several new characteristics on MSTIDs have been revealed by the TEC observations using the dense GPS receiver network in Japan. In this paper, we provide a short review of these new observations and summarize the morphological characteristics of MSTIDs in Japan.  相似文献   

Magnetic pulsation Pi2 as a sensitive indicator of magnetospheric substorm     

T. Saito  K. Yumoto  Y. Koyama 《Planetary and Space Science》1976,24(11):1025-1029

The identification of substorm onset is quite important in studying the mechanism of excitation of substorm disturbances. At present, one of the most practical methods to identify accurately the onset of substorms is to use low-latitude Pi2, which is sensitively related to the plasma instability in the magnetosphere, that triggers the substorm disturbances. This method is applied to examine the onset times of three substorm events which were already defined by various methods other than the low-latitude Pi2 method. Preceding the onset times, other evident substorm onsets are clearly determined with Pi2 onsets for all the three events by examining only the H-component of rapid-run magnetogram from a single low-latitude station in the dark hemisphere. Cooperative monitoring of Pi2 at three low-latitude stations on three well-separated meridians, therefore, is really effective in detecting most substorms.  相似文献   

The arch systems,cavities and prominences in the helmet streamer observed at the solar eclipse,November 12, 1966     

Kuniji Saito  E. Tandberg-Hanssen 《Solar physics》1973,31(1):105-121

Arch systems lying above quiescent prominences in the solar corona have long drawn the attention of eclipse observers, and such formations have been investigated since the end of the last century. Almost every eclipse photograph shows one or more arches, and in most cases the arch system is accompanied by a quiescent prominence below it and a helmet streamer above it. Also, in some cases there is a dark cavity between the arch system and the prominence.On large-scale photographs obtained at the November 12, 1966 eclipse, detailed photometry has been carried out on a formation in the corona composed of a helmet streamer straddling two multiple-arch systems each with a dark cavity and a quiescent prominence. The excess of electrons in the arches and the deficiency in the cavities are evaluated. We find that the formation of a prominence requires much more material than available in the cavity before depletion. Consequently the condensation theory of coronal matter into prominences seems to have difficulties explaining the necessary amount of matter in the cases where coronal arches - delineating magnetic field lines above the cavity - may exclude inflow of material from the corona. We comment on the low velocity of solar wind in the helmet streamer.The National Center for Atmospheric Research is sponsored by the National Science Foundation.  相似文献   

Volcanic events associated with an enigmatic submarine earthquake     

Hiroko Sugioka  Yoshio Fukao  Toshihiko Kanazawa  & Kenji Kanjo 《Geophysical Journal International》2000,142(2):361-370

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Vertical distributions of large ontogenetically migrating copepods in the Oyashio region during their growing season     

Atsushi Tsuda  Hiroaki Saito  Hiromi Kasai 《Journal of Oceanography》2014,70(2):123-132

Neocalanus flemingeri, Neocalanus plumchrus, Neocalanus cristatus and Eucalanus bungii are large and dominant mesozooplankton occurring throughout the subarctic Pacific. They are an important trophic link and transporter of organic matter to the mesopelagic zone. Vertical distributions of these copepods were investigated from March to October 2000 in the Oyashio region of the western subarctic Pacific. Neocalanus plumchrus and N. flemingeri were distributed in the surface layer (0–50 m) and N. cristatus and E. bungii in the subsurface layer (50–100 m). However, when examined in detail, clear seasonal and vertical differences were observed. Neocalanus plumchrus was concentrated in the top 20 m from late April to the end of July, and N. flemingeri showed a little deeper distribution from May to July. Neocalanus cristatus showed a deeper distribution than that of grazing individuals of E. bungii from April to early July, but grazing individuals of E. bungii (C3–C6) showed a deeper distribution than that of N. cristatus from the end of July to October. Early copepodites of E. bungii were distributed much shallower than late copepodite stages and overlapped with copepodites of N. plumchrus and N. flemingeri. These results suggest that the four species of large copepods have established habitat segregation by season, vertical distribution and food resource partitioning in the Oyashio region as well as other regions of the North Pacific.  相似文献   

Burial of organic carbon in Holocene sediments of the Zhujiang (Pearl River) and Changjiang (Yangtze River) estuaries   总被引：1，自引：0，他引：1  

Shouye Yang  Min Tang  Wyss W.-S. Yim  Yongqiang Zong  Guangqing Huang  Adam D. Switzer  Yoshiki Saito 《Marine Chemistry》2011,123(1-4):1-10

The East Asian marginal seas are important sinks of terrigenous materials transported by large rivers. In this study two cores from the Changjiang (Yangtze River) and Zhujiang (Pearl River) estuaries and one core from the inner shelf off of Hong Kong were investigated to examine the burial of organic matter during the postglacial period and its possible links with paleoenvironmental changes. Based on a simple two end-member mixing model, the terrestrial organic matter supplied primarily from the Zhujiang and Changjiang dominates the estuarine areas while marine organic matter contributes more to the inner-mid shelf. The competing contributions of terrestrial and marine organic matter are responsible for the downcore variations of organic elemental compositions. The overall decreasing shifts of total organic carbon concentrations and total organic carbon to total nitrogen ratios in the Zhujiang estuarine sediments since 6.5 kaBP seems to support the notion that depth profiles of organic matter compositions deposited in the Zhujiang Estuary can aid in the reconstruction of monsoon history in the Holocene. Nevertheless, organic matter compositions in the Changjiang Estuary and inner shelf off of southeastern Hong Kong respond in a different and more complex way to freshwater discharges or precipitation changes (monsoon variability) in the catchments, owing to complex controls of deposition and preservation of organic matter in these estuarine and shelf environments. Caution is therefore needed in using organic elemental and isotopic compositions to decipher paleoenvironmental changes in East Asian continental shelves where intense river–sea interactions occur and sedimentary environments change drastically.  相似文献   

Seasonal variation of bivalve larvae on an exposed sandy beach on Kashima-nada: Tips for the sandy beach recruitment process     

Hideki Sawada  Hajime Saito  Kumiko Adachi  Haruhiko Toyohara 《Journal of Sea Research》2011,65(2):275-283

Bivalves are often the dominant macrobenthos species in exposed sandy beach environments. However, our understanding of their recruitment processes before post-settlement stages on sandy beaches with highly energetic environments is incomplete. To clarify the characteristics of the free-swimming planktonic stage that affects recruitment efficiency in sandy shore ecosystems, we investigated the temporal (weekly–biweekly) variation of bivalve planktonic larval concentration coupled with oceanographic conditions on an exposed sandy shore on the sea of Kashima-nada, Japan, from summer 2003 to autumn 2005. Larvae were observed throughout the year, but the surge of larval concentration composed of sandy beach and sessile bivalves occurred most prominently in summer, from August to September. The peak concentration of larvae during this season was more than 1000 times higher than in other seasons. The larval concentration was positively correlated with water temperature and northward wind velocity and negatively correlated with each of the nutrient concentrations. On the other hand, chlorophyll a concentration and salinity seemed to have little effect on the larval concentration. Based on this fundamental knowledge, further investigations about planktonic larvae in sandy beaches are needed.  相似文献