Pharmacokinetics and acetylation of sulfamethoxazole in turbot <Emphasis Type="Italic">Scophthalmus maximus</Emphasis> after intravascular administration     

常志强  柳飞  连春盎  翟倩倩  李健 《中国海洋湖沼学报》2016,34(4):789-794

The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18°C were investigated. Either SMX (parent drug) or its acetylized metabolite, N₄-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two- and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h·kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.  相似文献   

Rainfall threshold determination for flash flood warning in mountainous catchments with consideration of antecedent soil moisture and rainfall pattern   总被引：1，自引：0，他引：1  

Xiaoyan Zhai  Liang Guo  Ronghua Liu  Yongyong Zhang 《Natural Hazards》2018,94(2):605-625

Flash flood disaster is a prominent issue threatening public safety and social development throughout the world, especially in mountainous regions. Rainfall threshold is a widely accepted alternative to hydrological forecasting for flash flood warning due to the short response time and limited observations of flash flood events. However, determination of rainfall threshold is still very complicated due to multiple impact factors, particular for antecedent soil moisture and rainfall patterns. In this study, hydrological simulation approach (i.e., China Flash Flood-Hydrological Modeling System: CNFF-HMS) was adopted to capture the flash flood processes. Multiple scenarios were further designed with consideration of antecedent soil moisture and rainfall temporal patterns to determine the possible assemble of rainfall thresholds by driving the CNFF-HMS. Moreover, their effects on rainfall thresholds were investigated. Three mountainous catchments (Zhong, Balisi and Yu villages) in southern China were selected for case study. Results showed that the model performance of CNFF-HMS was very satisfactory for flash flood simulations in all these catchments, especially for multimodal flood events. Specifically, the relative errors of runoff and peak flow were within?±?20%, the error of time to peak flow was within?±?2 h and the Nash–Sutcliffe efficiency was greater than 0.90 for over 90% of the flash flood events. The rainfall thresholds varied between 93 and 334 mm at Zhong village, between 77 and 246 mm at Balisi village and between 111 and 420 mm at Yu village. Both antecedent soil moistures and rainfall temporal pattern significantly affected the variations of rainfall threshold. Rainfall threshold decreased by 8–38 and 0–42% as soil saturation increased from 0.20 to 0.50 and from 0.20 to 0.80, respectively. The effect of rainfall threshold was the minimum for the decreasing hyetograph (advanced pattern) and the maximum for the increasing hyetograph (delayed pattern), while it was similar for the design hyetograph and triangular hyetograph (intermediate patterns). Moreover, rainfall thresholds with short time spans were more suitable for early flood warning, especially in small rural catchments with humid climatic characteristics. This study was expected to provide insights into flash flood disaster forecasting and early warning in mountainous regions, and scientific references for the implementation of flash flood disaster prevention in China.  相似文献   

A modified three-dimensional ionospheric tomography algorithm with side rays     

Yibin Yao  Changzhi Zhai  Jian Kong  Qingzhi Zhao  Cunjie Zhao 《GPS Solutions》2018,22(4):107

The three-dimensional ionospheric tomography (3DCIT) algorithm based on Global Navigation Satellite System (GNSS) observations have been developed into an effective tool for ionospheric monitoring in recent years. However, because the rays that come into or come out from the side of the inversion region cannot be used, the distribution of the rays in the edge and bottom part of the inversion region is scarce and the electron density cannot be effectively improved in the inversion process. We present a three-dimensional tomography algorithm with side rays (3DCIT-SR) applying the side rays to the inversion. The partial slant total electron content (STEC) of side rays in the inversion region is obtained based on the NeQuick2 model and GNSS-STEC. The simulation experiment results show that the algorithm can effectively improve the distribution of GNSS rays in the inversion region. Meanwhile, the iteration accuracy has also been significantly improved. After the same number of iterations, the iterative results of 3DCIT-SR are closer to the truth than 3DCIT, in particular, the inversion of the edge regions is improved noticeably. The GNSS data of the International GNSS Service (IGS) stations in Europe are used to perform real data experiments, and the inversion results show that the electron density profiles of 3DCIT-SR are closer to the ionosonde measurements. The accuracy improvement of 3DCIT-SR is up to 56.3% while the improvement is more obvious during the magnetic storm compared to the case of a calm ionospheric state .  相似文献   

鄂西地区二叠系孤峰组—大隆组沉积演化及其页岩气地质意义     

翟常博  牟传龙  梁薇  郑斌嵩  昝博文 《矿物岩石》2021,41(4):114-124

鄂西地区二叠系发育孤峰组、吴家坪组和大隆组三套黑色岩系,为页岩气探勘新主力层系,其沉积背景、沉积环境及时空分布却不尽一致.本次在前人的研究基础上,通过野外剖面和最新的钻井资料综合分析,对该地区二叠系孤峰组—大隆组沉积演化进行了深入解剖,并通过岩相古地理图约束了富有机质页岩的空间分布特征,旨在为鄂西地区二叠系页岩气地质调查和选区评价提供基础资料.研究认为,鄂西地区孤峰组主要发育盆地相碳质硅质泥岩,局部地区发育外缓坡相富有机质泥质灰岩;吴家坪组炭山湾段主要发育潮坪相泥质粉砂岩夹煤层,并在利川地区发育陆棚相的碳质硅质泥岩;吴家坪组灰岩段主要为内缓坡相的生屑泥晶灰岩.大隆组主要发育盆地相碳质硅质泥岩,其次为外缓坡相富有机质泥质灰岩,利川见天坝可见发育内缓坡边缘点礁.综合前人对各层位研究的页岩气参数认为,鄂西地区孤峰组和大隆组具有有机质含量高(＞2％)、厚度大(＞20 m)、脆性矿物含量高(＞60％)等形成页岩气的基本地质条件,深水盆地相为有利相带;吴家坪组炭山湾段潮坪相的黑色泥岩较薄(＜10 m),连续性差,但利川地区吴家坪组炭山湾段深水陆棚相黑色泥岩厚度较大(～30 m),为潜在的页岩气勘探区域.  相似文献   

谈新形势下地勘单位改革发展的现状及未来发展方向     

闫国红  王瑞丰  张成兵  翟延亮  韩立红  马双双  王海明  姚伟 《中国煤炭地质》2021,(3):79-82

新中国成立以来,地勘单位先后在计划经济和市场经济下为国家的发展做出了重要贡献,也先后经历了初步探索、属地化管理、事企分体运行等不同阶段。十九大以来,随着事业单位改革的逐步深入,地勘单位改革迫在眉睫。为了更好的适应时代发展,又快又好地进行地勘单位转型,通过研究不同历史时期地勘单位发展的问题和困难,指出现阶段面临的主要问题是改革意愿不强烈、转型工勘领域受阻、资本占有率低和人才匮乏。以此为基础,提出转变思想、学习集团化企业路线、投身地方产业结构、全面提升自然资源意识、加强自身建设和长期持续稳定转型的发展建议,供转型发展的地勘单位参考。  相似文献   

一次沿海局地特大暴雨的集合敏感性分析     

陈伟斌  翟舒楠  韩慎友  陈见 《气象研究与应用》2019,40(1):11-15

利用常规观测资料和EC集合预报资料,基于集合敏感性方法 ,首先分析了2018年10月21日广西沿海局地特大暴雨过程的降水影响天气系统及关键区,并进一步分析了集合预报效果,得到不同层次气压场及风场的降水敏感特征以及集合预报降水预报偏差的可能主要原因,所得结论可供预报参考。  相似文献   

对于点苍山-石鼓变质带区域划分的意见   总被引：9，自引：7，他引：9  

翟明国  从柏林 《岩石学报》1993,9(3):227-239

在以往的研究中,点苍山和哀牢山被认为是同一个变质带。对石鼓带的划分也有很大争议。本文通过岩石学和同位素年代学的研究,认为点苍山和石鼓变质带同为扬子基底的一部分,应属于滇东变质区。它们是在元谋-大红山群之上发育的一套中晚元古变质岩带,具陆内地台型火山-沉积的特点。  相似文献   

怀安蔓菁沟早前寒武纪高压麻粒岩混杂岩带地质特征、岩石学和同位素年代学   总被引：11，自引：19，他引：11  

郭敬辉  翟明国  张毅刚  李永刚  阎月华  张雯华 《岩石学报》1993,(4)

华北克拉通北缘中段怀安蔓菁沟高压麻粒岩混杂岩带产在太古宙怀安杂岩南缘与花岗岩带交界处,由高压基性麻粒岩、辉长质麻粒岩、英云闪长质麻粒岩和少量夕线石榴片麻岩相间排列的席状岩层构成,岩层间被高应变带或剪切带分隔。高压基性麻粒岩是石榴辉石麻粒岩。据石榴石斑晶内包裹的早期矿物(Cpx+Q)估算的早期高压变质作用条件:T=800℃,P>1.4GPa。环绕斑晶的后成合晶反应边矿物组合(P1+Opx+Hb+Cpx)的变质条件为:T=820℃,P为0.7～0.9GPa。全岩Sm-Nd等时线年龄2.65Ga,矿物Sm-Nd等时线年龄1.82Ga,锆石U-Pb一致线年龄1.83Ga。高压基性麻粒岩的原岩代表晚太古代陆壳的最下部,大约在2.7Ga从上地幔分异出来,可能经壳下垫托作用加在早期陆壳底部,随后经历高压变质作用。早元古代晚期,由于地壳规模的大型逆冲作用,使其上升,并经受褶皱形变、剪切推覆和退变质等作用的改造,形成高压麻粒岩混杂岩带。  相似文献   

长江流域旱涝典型年大气水汽输送   总被引：6，自引：0，他引：6       下载免费PDF全文

高国栋  翟盘茂 《水科学进展》1993,4(1):10-16

利用我国125个探空站一日两次自地面至100hpa共11个层次上的观测资料,对长江流域典型夏涝年(1980年)和夏旱年(1985年)我国大气中水汽总输送场、涡动输送场及散度场进行了计算分析。结果表明:当水汽总输送场从西北、西南和东南三支气流携带的水汽交汇于长江流域,且整个水汽输送场稳定持久,则在水汽辐合带附近导致大量降水,形成洪涝;反之,当三支气流微弱不稳定,不能形成水汽辐合带条件,则形成干旱。涡动输送亦反映出类似的特征。稳定且强盛的西南气流水汽输送是形成降水的主要条件和原因。  相似文献   

中国近海海面地形的计算与研究   总被引：3，自引：1，他引：3       下载免费PDF全文

翟国君  赵明才 《水科学进展》1993,4(3):161-170

介绍了海面地形的研究现状,并根据几何水准求得了中国近海的海平面倾斜及其精度.给出应用水文资料计算中国近海海面地形的公式及其计算结果.探讨了由球函数模型计算中国近海海面地形的理论和方法,并对不同方法进行了比较,得出了一些有益的结论.  相似文献