Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice     

夏冬  刘冰  栾希英  孙军燕  刘娜娜  秦松  杜振宁 《中国海洋湖沼学报》2016,34(2):399-404

Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.  相似文献   

藻蓝蛋白抗氧化作用及其药理活性研究进展   总被引：3，自引：0，他引：3  

夏冬  孙军燕  刘娜娜  刘冰  杜振宁 《海洋科学》2015,39(7):130-135

  相似文献   

水产动物源胶原蛋白医学应用研究进展   总被引：1，自引：0，他引：1  

王明超  李杰  秦松  杜振宁  李文军 《海洋科学》2018,42(12):109-117

胶原蛋白具有免疫原性低,生物相容性较好等优点,同时还具有可降解、止血和促进细胞生长增殖的特性。其中水产源胶原蛋白在提取工艺、安全性方面具有更大优势,因此在医学应用方面得到了广泛的研究与应用。本文探讨了水产动物源胶原蛋白在医学应用方面的研究进展,为后续的研究工作提供依据。  相似文献   

藻蓝蛋白对氧化应激相关疾病防治作用的研究进展   总被引：1，自引：1，他引：0  

刘琪  李文军  唐志红  秦松  杜振宁 《海洋科学》2017,41(10):132-138

过去的40年,氧化应激在多种疾病的发生及恶化进程中的重要作用受到广泛关注。机体受到有害刺激后产生的氧化应激与动脉粥样硬化、肝炎、肺炎、阿尔兹海默病、白内障等多种疾病的发生有关,减轻氧化应激来防治以上疾病成为一种新思路。藻蓝蛋白作为从藻类中提取的天然产物,常被用作保健品及食品添加物,研究发现藻蓝蛋白可通过消除自由基、减轻氧化应激防治多种疾病。本文将藻蓝蛋白对氧化应激相关疾病的治疗或预防作用进行了综述,对其应用前景进行展望,为该活性蛋白的应用提供参考。  相似文献