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刘义保 《华东地质学院学报》1999,22(1):78-82
胰岛素是调节细胞代谢和生长的重要激素。本文放射性同位素实验测定。进一步说明了脉冲电场对胰岛素与其受体结合的影响,经电场处理过的胰岛素与受体结合的能力虽然降低,但电场刺激后细胞,其膜上受体与胰岛素结合的常数增大。 相似文献
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Chunyan Zhao Shihong Xu Yifan Liu Chengcheng Feng Yongshuang Xiao Yanfeng Wang Qinghua Liu Jun Li 《海洋学报(英文版)》2022,41(1):84-98
In most fish,reproduction is seasonal or periodic under the suitable conditions.In turbot(Scophthalmus maximus)farms,one of the most economically important marine flatfish species,changes in daylength could cause changes in the spawning time.In this study,to characterize the regulation of reproductive physiology following light signals,three melatonin receptors(Mtnr)investigated in turbot were named sm Mtnr1,sm Mtnr2,and sm Mtnr1 c.Distinct expression profiles demonstrated that Mtnr m RNAs were concentrated in the brain(as detected in the hypothalamus(Hy)and mesencephalon(Me)),gonad and eye.The most abundant Mtnr1 and Mtnr2 m RNA expression levels were detected in the central nervous system at the beginning of the breeding season,suggesting that Mtnr1 and Mtnr2 may play vital roles in the regulation of turbot gonadal development.In addition,the melatonin profiles gradually increased and reached to the highest level at the spawning stage,indicating that melatonin is a potent hormone in the regulation of fish oocyte growth and maturation.The results of this study suggested that melatonin is the primary factor that transduces the light signal and regulates the physiological functions of turbot seasonal reproduction.Moreover,the results of this study may establish a foundation for further research seeking to identify fish melatonin receptors involved in the gonadal development and gamete maturation. 相似文献
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全球气候和环境变化影响海洋动物的生长发育和繁殖等生命过程,探究环境因子调控发育的分子机制,需要深入了解海洋动物早期发育的生理和分子特征。以实验室驯化的潜在模式动物海洋线虫Litoditis marina为研究对象,对其胚胎期和孵化后发育早期2h、4h和6h的L1幼虫样品进行了转录组测序和分析。结果表明,2h、4h和6h的L1幼虫间差异较小,而三个L1幼虫样品与胚胎期相比,基因表达发生了显著变化。通过KEGG富集分析,发现与胚胎期相比,三个L1幼虫样品的多个通路如核糖体、核糖体生物发生、糖酵解/糖原异生、TCA循环和氧化磷酸化通路相关基因发生了显著上调。另外还发现多个神经递质和神经肽受体基因如dop-和npr-等在L1期转录水平显著上调。与胚胎期相比,L1幼虫的多个DNA复制和修复相关、Notch、Hippo和Hedgehog信号和剪切体等通路相关基因发生了显著下调。发现的L. marina早期发育转录组变化模式与已经发表的陆生模式生物秀丽线虫Caenorhabditis elegans从胚胎期到L1幼虫的转录组变化特征非常相似,但同一上调或下调通路中具体发生表达变化的基因有些不同。另外,L1幼虫显著上调的核糖体生物发生通路相关基因在秀丽线虫中发生了显著下调。进一步通过基因编辑等技术和方法深入研究发育调控关键基因的功能将为海陆近缘线虫间的发育进化机制、海洋线虫对潮间带环境适应以及全球气候变化应答的分子机制研究提供新认知。 相似文献
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P. Kumar 《Journal of Earth System Science》2005,114(5):565-571
Based on the inherent property of symmetry of air pollution models, a Symmetrical Air Pollution Model Index (SAPMI) has been
developed to calibrate the accuracy of predictions made by such models, where the initial quantity of release at the source
is not known. For exact prediction the value of SAPMI should be equal to 1. If the predicted values are overestimating then
SAPMI is <1 and if it is underestimating then SAPMI is >1. Specific design for the layout of receptors has been suggested
as a requirement for the calibration experiments. SAPMI is applicable for all variations of symmetrical air pollution dispersion
models. 相似文献
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Various synthetic compounds are frequently discharged into the environment via human activities. Among them, certain contaminants may disrupt normal physiological functions of wildlife and humans via interactions with nuclear receptors. To protect human health and the environment, it is important to detect environmental ligands for human nuclear receptors. In this study, yeast-based reporter gene assays were used to investigate the occurrence of xenobiotic ligands for retinoid X receptors (RXR) and thyroid hormone receptors (TR) in the aquatic environment of Taiwan. Experimental results revealed that RXR agonist/antagonist activity was detected in river water and sediment samples. In particular, high RXR agonist/antagonist activity was found in the samples collected near river mouths. Additionally, few samples also elicited significant TR antagonist activity. Our findings show that the aquatic environment of Taiwan was contaminated with RXR and TR ligands. Further study is necessary to identify these xenobiotic RXR and TR agonists and antagonists. 相似文献
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《Geofísica Internacional》2014,53(1):39-57
The use of Artificial Neural Networks (ANN) is explored to predict peak ground accelerations (PGA) and pseudospectral acceleration (SA) for Mexican inslab and interplate earthquakes. A total of 277 and 418 seismic records with two horizontal components for inslab and interplate earthquakes, respectively, are used to train the ANN models by using an ANN with a feed-forward architecture with a back-propagation learning algorithm. Both ANN with single and two hidden layers are considered. For comparison purposes, the PGA and SA values predicted by the trained ANN models are compared with those estimated with attenuation relations or ground motion prediction equations (GMPEs). The comparison indicates that the predicted PGA and SA values by the trained ANN models, in general, follow the trends predicted by the GMPEs. However, an extensive verification of the trained models must be conducted before they can be used for seismic hazard and risk analysis since, on occasion, the PGA and SA values predicted by the trained ANN models depart from the behaviour observed from the actual records. 相似文献
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实验观察磷酸吡哆醛对培养的海马神经细胞形态学的影响 ,选用妊娠 18d Wistar大鼠胎鼠 ,采用酶消化法获得单个海马神经细胞 ,通过原代低密度细胞培养法观察磷酸吡哆醛 (PLP)对其形态学的影响。结果表明 :在浓度为 1,10μ m时 ,能明显地促进海马神经细胞轴突的伸展 ,但对树突总长度、每个轴突上的分叉数及胞体的突起数均无明显影响 ;Ifenprodil和 Picrotoxin尽管能明显拮抗 PL P介导的神经细胞营养作用 ,但对 PL P的促神经细胞伸展作用却无明显影响。总之 ,认为 PL P之所以具有促海马神经细胞轴突伸展作用 ,不是通过 PL P神经细胞的营养作用来发挥的。其详细机理有待于进一步探讨 相似文献
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克隆了三疣梭子蟹TLR家族的一个新基因,将其命名为PtToll6。该基因全长为4 034 bp,预测分子量为109.078 kDa,理论等电点为6.06,共编码977个氨基酸。SMART预测显示, PtToll6具有Toll样受体典型的结构域,包括前端的序列区(LRR)、跨膜区(TM)和胞内(TIR)区,进化树分析表明其与同属节肢动物门的果蝇Dmtoll9聚为一支。组织表达分布结果显示,PtToll6在肝胰腺中特异性地高表达,其次表达于肠道,在鳃中的表达量最低。采用3种PAMPs进行注射刺激,发现PtToll6对脂多糖的响应最为强烈,在感染48 h后的表达量为对照组的上千倍,推测其可能为PtToll6基因主要识别的病原相关分子模式。PtToll6在人工感染副溶血弧菌后的12 h开始上调表达,至24 h达到峰值(上调9.02倍)。采用RNAi敲降PtToll6后, MyD88的表达量相应下调,同时发现感染副溶血弧菌后的死亡率显著提高,为阴性对照组的1.8倍。实验结果表明:PtToll6基因在抗副溶血弧菌中发挥重要功能。本实验对解析三疣梭子蟹抵御病原入侵的分子机制具有重要指导作用。 相似文献
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