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M. Cristina Fossi Silvia Casini Letizia Marsili Stefania Ancora Gabriele Mori Giovanni Neri Antonella Ausili Teresa Romeo Alessandra Moscatelli Giuseppe Notarbartolo Di Sciara 《Marine Ecology》2002,23(S1):184-189
Abstract. Endocrine Disrupting Chemicals (EDCs) have the potential to alter hormone pathways that regulate reproductive processes in wildlife and fisheries. In this research the unexplored hypothesis that Mediterranean top predator species (such as large pelagic fish and marine mammals) are potentially at risk due to EDCs is investigated. In the Mediterranean environment, top predators accumulate high concentrations of polyhalogenated aromatic hydrocarbons (PHAHs) and toxic metals, incurring high toxicological risk. Here we illustrate the need to develop sensitive biomarkers for evaluation of toxicological risk in top marine predators (Xiphias gladius, Thunnus thynnus thynnus) and non-lethal techniques, such as non-destructive biomarkers, for the hazard assessment of threatened species exposed to EDCs, such as marine mammals ( Stenella coeruleoalba, Tursiops truncatus, Delphinus delphis and Balaenoptera physalus ). 相似文献
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Marsili L Casini S Bucalossi D Porcelloni S Maltese S Fossi MC 《Marine environmental research》2008,66(1):151-153
The aim of the present study was to propose the immunofluorescence technique in cultured fibroblasts from Mediterranean cetaceans as a new "in vitro" tool to explore the susceptibility of these marine mammals to different xenobiotic compounds. The cell lines were cultured from integument biopsies of free-ranging and stranded cetaceans (dead within 12h). Using the indirect immunofluorescence assay, we detected endogenous proteins induced by different contaminants. Here we present the method used for qualitative and quantitative evaluation of cytochromes P450 (CYP1A1 and CYP2B) induced by some POPs (DDTs and PCBs) and emerging contaminants (PBDEs) in fibroblast cell cultures of striped dolphin (Stenella coeruleoalba) and bottlenose dolphin (Tursiops truncatus). Immunofluorescence was quantified with a specially designed Olympus macro, DetectIntZ. A major result was the possibility of using this "in vitro" assay to quantify induction of endogenous proteins. 相似文献
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Acta Geotechnica - The increasing understanding of the connection between particle morphology and mechanical behaviour of granular materials has generated significant research on the quantitative... 相似文献
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Fossi MC Borsani JF Di Mento R Marsili L Casini S Neri G Mori G Ancora S Leonzio C Minutoli R Notarbartolo di Sciara G 《Marine environmental research》2002,54(3-5):761-767
The aim of this study was to propose a suite of biomarkers (BPMO activity, NADPH-cytocrome c reductase, NADH-ferricyanide reductase. esterases, porphyrins, vitellogenin and zona radiata proteins) and residue levels (organochlorines, PAHs and heavy metals) in the zooplanktonic euphausiid Meganyctiphanes norvegica as a potential multi-disciplinary diagnostic tool for assessment of the health status of the Mediterranean "whale sanctuary". Very little difference in BPMO was detected between sites, with values ranging from 0.75 to 2.68 U.A.F./mg prot/h. On the other hand larger differences between sites were found for reductase activities. Esterases (AChE), porphyrins (Copro-, Uro-, Proto-porphyrins) vitellogenin and zona radiata proteins were also detectable in this zooplanctonic species. Hg showed mean levels of 0.141 ppm d.w., Cd 0.119 ppm d.w. and Pb 0.496 ppm d.w. Total PAHs ranged from 860.7 to 5,037.9 ng/g d.w., carcinogenic PAHs from 40.3 to 141.7 ng/g d.w., HCB from 3.5 to 11.6 ng/g d.w., DDTs from 45.3 to 163.2 ng/g d.w. and the PCBs from 84.6 to 210.2 ng/g d.w. 相似文献
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Fossi MC Casini S Marsili L Ancora S Mori G Neri G Romeo T Ausili A 《Marine environmental research》2004,58(2-5):425-429
In this project we investigated the ecotoxicological effects of endocrine disrupters in a four-year survey of the Mediterranean population of swordfish (Xiphias gladius). In the Mediterranean environment, top predators, such as swordfish, accumulate high concentrations of polyhalogenated aromatic hydrocarbons (PHAHs) and toxic metals, potentially incurring high toxicological risk. The effects of organochlorines and trace elements (Hg, Cd and Pb) in 192 swordfish specimens, caught in the Strait of Messina, Sicily, Italy, were investigated using vitellogenin (Vtg), zona radiata proteins (Zrp) and CYP1A (BPMO, EROD) activities. Vtg and Zrp were found to be dramatically induced in some adult male specimens, suggesting that this species is highly exposed to estrogens in the Mediterranean Sea. A role of organochlorines in this induction phenomenon is suggested by the statistically significant correlations between Zrp in plasma and PCB concentrations in muscle (p<0.032) and Vtg in plasma and PCB concentrations in liver (p<0.034) of male specimens. Levels of trace elements in liver were in the following ranges: Hg 1-22, Cd 1-28 and Pb 0-1.6 ppm d.w. These data indicate potential reproductive alterations in large pelagic fish and suggest the need for continuous monitoring to avoid reductions in the population of this fish species of high commercial and ecological interest. 相似文献
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M. Cristina Fossi Silvia Casini Letizia Marsili Stefania Ancora Gabriele Mori Giovanni Neri Teresa Romeo Antonella Ausili 《Marine environmental research》2004,58(2-5):425
In this project we investigated the ecotoxicological effects of endocrine disrupters in a four-year survey of the Mediterranean population of swordfish (Xiphias gladius). In the Mediterranean environment, top predators, such as swordfish, accumulate high concentrations of polyhalogenated aromatic hydrocarbons (PHAHs) and toxic metals, potentially incurring high toxicological risk. The effects of organochlorines and trace elements (Hg, Cd and Pb) in 192 swordfish specimens, caught in the Strait of Messina, Sicily, Italy, were investigated using vitellogenin (Vtg), zona radiata proteins (Zrp) and CYP1A (BPMO, EROD) activities. Vtg and Zrp were found to be dramatically induced in some adult male specimens, suggesting that this species is highly exposed to estrogens in the Mediterranean Sea. A role of organochlorines in this induction phenomenon is suggested by the statistically significant correlations between Zrp in plasma and PCB concentrations in muscle (p<0.032) and Vtg in plasma and PCB concentrations in liver (p<0.034) of male specimens. Levels of trace elements in liver were in the following ranges: Hg 1–22, Cd 1–28 and Pb 0–1.6 ppm d.w. These data indicate potential reproductive alterations in large pelagic fish and suggest the need for continuous monitoring to avoid reductions in the population of this fish species of high commercial and ecological interest. 相似文献
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G. Giono R. Ishikawa N. Narukage R. Kano Y. Katsukawa M. Kubo S. Ishikawa T. Bando H. Hara Y. Suematsu A. Winebarger K. Kobayashi F. Auchère J. Trujillo Bueno S. Tsuneta T. Shimizu T. Sakao J. Cirtain P. Champey A. Asensio Ramos J. Štěpán L. Belluzzi R. Manso Sainz B. De Pontieu K. Ichimoto M. Carlsson R. Casini M. Goto 《Solar physics》2017,292(4):57
The Chromospheric Lyman-Alpha SpectroPolarimeter is a sounding rocket instrument designed to measure for the first time the linear polarization of the hydrogen Lyman-\({\upalpha }\) line (121.6 nm). The instrument was successfully launched on 3 September 2015 and observations were conducted at the solar disc center and close to the limb during the five-minutes flight. In this article, the disc center observations are used to provide an in-flight calibration of the instrument spurious polarization. The derived in-flight spurious polarization is consistent with the spurious polarization levels determined during the pre-flight calibration and a statistical analysis of the polarization fluctuations from solar origin is conducted to ensure a 0.014% precision on the spurious polarization. The combination of the pre-flight and the in-flight polarization calibrations provides a complete picture of the instrument response matrix, and a proper error transfer method is used to confirm the achieved polarization accuracy. As a result, the unprecedented 0.1% polarization accuracy of the instrument in the vacuum ultraviolet is ensured by the polarization calibration. 相似文献
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The behavior of a partially saturated soil during surface‐water infiltration is analyzed by means of an elasto‐plastic constitutive model formulated in terms of effective stress and extended to unsaturated conditions. The model is calibrated considering laboratory‐scale experimental results under suction‐controlled conditions. The wetting process in two collapsing soils, initially loaded at in situ stresses, is simulated by imposing two different boundary conditions: surface ponding and water flow. The stress paths resulting from the imbibition process are analyzed at different points inside the layer. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Leonardo Casini Stefano Andreucci Daniele Sechi Chun‐Yuan Huang Chuan‐Chou Shen Vincenzo Pascucci 《地学学报》2020,32(4):261-271
Precise dating of the activity of Late Pleistocene to Holocene neo‐tectonic structures is crucial to quantify the rate of deformation in low‐seismicity regions. Sardinia is a relatively stable continental fragment set in the middle of the tectonically active Western Mediterranean belt. This paper provides evidences of significant uplift of northwest Sardinia that support an ongoing tectonic activity since the Marine Isotopic Stage 7 (MIS 7; ca. 220 ka). In particular, it documents for the first time Late Pleistocene to Holocene tectonics based on luminescence dating of travertine sealing a major NNE‐SSW fault. 相似文献