胃复方的急性毒性实验研究          下载免费PDF全文

胡花婷  李东芳  何侃成 《应用海洋学学报》2019,35(12):109-112

目的：对胃复方进行急性毒性实验研究，观察其安全性。方法：将实验小鼠按体质量随机分为2组，采用最大给药量法测定小鼠口服胃复方的最大耐受量，给药组24h内2次以最大浓度、最大体积的中药胃复方给予小鼠灌胃，对照组小鼠灌服等剂量蒸馏水，观察记录2组小鼠一般情况及死亡情况，对主要脏器进行病理组织学检测。结果：给药组小鼠一般情况良好，无1例死亡。与对照组比较，体质量变化差异无统计学意义（P>0.05）；主要脏器病理组织学检测未见明显异常；最大给药量为221.7g生药/kg，相当于60kg成人临床推荐剂量的127倍。结论：胃复方无明显毒性，在规定剂量下用药是安全可靠的。  相似文献   

Silicon limitation on primary production and its destiny in Jiaozhou Bay, China——Ⅳ：Study on cross-bay transect from estuary to ocean   总被引：1，自引：0，他引：1  

Yang Dongfang  Chen Yu  Gao Zhenhui  Zhang Jing  Wang Fan 《中国海洋湖沼学报》2005,23(1):72-90

The authors analyzed the data collected in the Ecological Station Jiaozhou Bay from May 1991 to November 1994, including 12 seasonal investigations, to determine the characteristics, dynamic cycles and variation trends of the silicate in the bay. The results indicated that the rivers around Jiaozhou Bay provided abundant supply of silicate to the bay. The silicate concentration there depended on river flow variation. The horizontal variation of silicate concentration on the transect showed that the silicate concentration decreased with distance from shorelines. The vertical variation of it showed that silicate sank and deposited on the sea bottom by phytoplankton uptake and death, and zooplankton excretion. In this way, silicon would endlessly be transferred from terrestrial sources to the sea bottom. The silicon took up by phytoplankton and by other biogeochemical processes led to insufficient silicon supply for phytoplankton growth. In this paper, a 2D dynamic model of river flow versus silicate concentration was established by which silicate concentrations of 0.028–0.062 μmol/L in seawater was yielded by inputting certain seasonal unit river flows (m³/s), or in other words, the silicate supply rate; and when the unit river flow was set to zero, meaning no river input, the silicate concentrations were between 0.05–0.69 μmol/L in the bay. In terms of the silicate supply rate, Jiaozhou Bay was divided into three parts. The division shows a given river flow could generate several different silicon levels in corresponding regions, so as to the silicon-limitation levels to the phytoplankton in these regions. Another dynamic model of river flow versus primary production was set up by which the phytoplankton primary production of 5.21–15.55 (mgC/m²·d)/(m³/s) were obtained in our case at unit river flow values via silicate concentration or primary production conversion rate. Similarly, the values of primary production of 121.98–195.33 (mgC/m²·d) were achieved at zero unit river flow condition. A primary production conversion rate reflects the sensitivity to silicon depletion so as to different phytoplankton primary production and silicon requirements by different phytoplankton assemblages in different marine areas. In addition, the authors differentiated two equations (Eqs. 1 and 2) in the models to obtain the river flow variation that determines the silicate concentration variation, and in turn, the variation of primary production. These results proved further that nutrient silicon is a limiting factor for phytoplankton growth. This study was funded by NSFC (No. 40036010), and the Director's Fund of the Beihai Sea Monitoring Center, the State Oceanic Administration.  相似文献   

岭南城市居住小区生态系统及其规划     

何东方 《热带地理》1997,17(3):247-252

本文探讨了城市居住小区生态系统，提出了城市生态居住小区的关键因素，最后对岭南城市生态居住小区规划进行了探索。  相似文献   

The Scientific Conceptual Framework for Ecological Quality of the Dryland Ecosystem: Concepts,Indicators, Monitoring and Assessment     

WU Rina  CONG Weiwei  LI Yonghua  LI Siyao  WANG Dongfang  JIA Zhiqing  WANG Feng 《资源与生态学报(英文版)》2019,10(2):196-201

The dryland ecosystem is the dominant component of the global terrestrial ecosystem since arid regions occupy 45% of the earth’s land area and feed 38% of the world's population. The stability and sustainable development of the dryland ecosystem are critical for achieving the millennium development goal (MDG) in the arid and semiarid areas. However, there is still no scientific guideline for measuring and conserving the health and productivity of dryland ecosystems. Therefore, the purpose of this study is to develop the scientific conceptual framework of defining, monitoring and evaluating the ecological quality of dryland ecosystems. The ecological quality of dryland ecosystems is represented by a system of comprehensive indicators that are each extracted from the ecological elements, and structural and functional indices of the ecosystem. These indicators can be monitored by integrating satellites and unmanned aerial vehicles with ground-based sensor networks at the scale of either observational sites or regional scales. Finally, the ecological quality can be evaluated by evaluation models based on the normalized index values and their thresholds. This paper presents a conceptual framework for monitoring and evaluating the ecological quality of drylands, which provides a way of advancing the monitoring, diagnosis, and evaluation of the ecological quality of the dryland ecosystems.  相似文献   

均方误差意义下的正则化参数二次优化方法     

林东方  朱建军  付海强  张兵 《测绘学报》2020,49(4):443-451

Tikhonov正则化法是大地测量中应用最为广泛的病态问题解算方法之一。影响正则化法解算效果的重要因素是正则化参数,然而,最优正则化参数的确定一直是正则化解算的难题,如L曲线法确定的正则化参数具有稳定性好、可靠性高的优点,但存在过度平滑问题,导致正则化法对模型参数估值精度改善较小。本文从均方误差角度分析了正则化参数对模型参数估计质量的影响。基于奇异值分解技术,提出了由模型参数投影值分块计算均方误差的方法,避免了均方误差迭代计算,并基于均方误差最小准则给出了正则化参数优化方法,实现了对L曲线正则化参数的优化。数值模拟试验与PolInSAR植被高反演试验结果表明,正则化参数优化方法有效改善了正则化法解算效果,提高了模型参数估计精度。  相似文献   

西藏多不杂斑岩铜矿床高温高盐度流体包裹体及其成因意义   总被引：22，自引：1，他引：22  

佘宏全  李进文  丰成友  马东方  潘桂棠  李光明 《地质学报》2006,80(9):1434-1447

多不杂铜矿为班公湖—怒江缝合带上发现的第一处大型斑岩铜矿床,矿床位于羌塘—三江复合板片南缘的多不杂构造岩浆带中。多不杂斑岩铜矿总体上具有典型的斑岩铜矿矿石特征和蚀变分带特点,围绕斑岩体从岩体中心向外,可以划分出三个主要的蚀变带,依次为钾硅化 绢英岩化带、绢英岩化带和黄铁矿化—角岩化带。矿床以岩体内部和外部均发育强烈的磁铁矿化蚀变、而外围青磐岩化带不发育等特征有别于国内其他斑岩铜矿。对斑岩铜矿的流体包裹体特征和均一测温结果表明斑岩铜矿石英含有丰富的流体包裹体,包裹体类型众多,而以大量发育含子矿物多相包裹体为突出特征。子矿物种类有石盐、钾盐、赤铁矿、红钾铁盐、石膏、黄铜矿等,有时一个包裹体含有多达5~6个子矿物,在我国其他斑岩铜矿中是不多见的。金属子矿物大量发育表明流体成矿金属元素含量很高。成矿流体由来自岩浆的高温、高盐度流体和以天水成因为主的中低温、低盐度流体两个流体端员组份组成。高温、高盐度流体为主要成矿流体,以含子矿物多相流体包裹体为代表,其形成温度>450℃,盐度在28%~83%NaClequ.,平均达到58%~60%NaClequ.,流体组分主要属于H2O-NaCl-KCl-FeCl2体系。高温高盐度流体是在浅成条件下于岩浆结晶的最后阶段从浅部岩浆中直接出溶形成的。中低温、低盐度流体主要来源于天水或天水与晚期岩浆热液的混合,温度在360℃以下,盐度3.71%~14.15%NaClequ.。含矿硫化物主要在300~420℃温度区间沉淀,沉淀富集主要与温度降低有关,多不杂斑岩铜矿为与浅成斑岩体侵入有关的高温岩浆热液型斑岩铜矿。与世界上其他斑岩铜矿相比,多不杂斑岩铜矿具有与Bingham和Grasberg等世界级超大型斑岩铜矿相似的流体包裹体和蚀变分带特征,暗示该矿床具备形成超大型斑岩铜矿的潜力。  相似文献   

黑龙江省气候变化趋势对小麦产量的影响     

高永刚  齐东方  喻晓天  张剑侠  南瑞 《黑龙江气象》2007,(4):1-3,7

利用黑龙江省1961～2003年逐日气象资料,采用世界粮食研究模型(WOFOST)和气候变化趋势分析的数学方法,分析了气候变化趋势对小麦产量变化趋势的影响.在黑龙江省中部、东部和北部相对湿润的小麦种植区域,辐射量降低趋势是小麦模拟产量降低趋势的主要气候原因;在松嫩平原西南部的齐齐哈尔市、大庆市和哈尔滨市,降水量增加的趋势是小麦模拟产量增加趋势的主要气候原因;在西北部的北安、五大连池、克山和克东4县,辐射量增加趋势是小麦模拟产量增加趋势的主要气候原因;黑龙江省小麦模拟产量变化趋势百分率的平均值为-1.57%/10a.  相似文献   

Influence of Seawater Temperature on Phytoplankton Growth in Jiaozhou Bay, China   总被引：3，自引：0，他引：3  

杨东方  高振会陈豫王培刚  孙培艳 《中国海洋湖沼学报》2004,22(2):166-175

The phytoplankton reproduction capacity (PRC), as a new concept regarding chlorophyll-a and primary production (PP) is described. PRC is different from PP, carbon assimilation number (CAN) or photosynthetic rate ( P^B ) . PRC quantifies phytoplankton growth with a special consideration of the effect of seawater temperature. Observation data in Jiaozhou Bay, Qingdao, China, collected from May 1991 to February 1994 were used to analyze the horizontal distribution and seasonal variation of the PRC in Jiaozhou Bay in order to determine the characteristics, dynamic cycles and trends of phytoplankton growth in Jiaozhou Bay; and to develop a corresponding dynamic model of seawater temperature vs. PRC. Simulation curves showed that seawater temperature has a dual function of limiting and enhancing PRC. PRC‘s periodicity and fluctuation are similar to those of the seawater temperature. Nutrient silicon in Jiaozhou Bay satisfies phytoplankton growth from June 7 to November 3. When nutrients N, P and Si satisfy the phytoplankton growth and solar irradiation is sufficient, the PRC would reflect the influence of seawater temperature on phytoplankton growth. Moreover, the result quantitatively explains the scenario of one-peak or two-peak phytoplankton reproduction in Jiaozhou Bay, and also quantitatively elucidates the internal mechanism of the one- or two-peak phytoplankton reproduction in the global marine areas.  相似文献   

枣庄市国土资源局山亭分局扎实开展民主评议政风行风工作     

李东方 《山东地质》2010,(5):50-51

民主评议政风行风是促进单位部门转变职能、提高效率、优化服务的重要举措。山亭国土资源分局以民主评议政风行风为契机,通过＂五个结合＂,实现了服务质量和工作效率的＂三个转变＂,得到了社会各界的好评。  相似文献   

利用TSVD参数估值变化特性确定算法截断参数     

林东方  姚宜斌  郑敦勇  李朝奎 《测绘学报》2022,51(8):1787-1796

TSVD是大地测量病态问题解算的常用有效方法。影响TSVD解算效果的关键因素是截断参数,现有截断参数确定方法可提供有效的截断参数,但仍难以给出最优截断参数。以均方误差最小为准则确定截断参数是一种理论依据较充分的截断参数确定方法,但均方误差计算所需的模型参数真值在实际应用中无法获得,导致该方法难以给出理论最优截断参数。鉴于此,本文研究了基于均方误差影响下(方差与偏差联合影响)参数估值变化特性的TSVD截断参数确定方法。通过TSVD依次截掉小奇异值,获得奇异值截掉前后的方差与参数估值变化,利用两者变化分析确定偏差影响,避免依赖参数真值计算偏差,从而确定出均方误差最小理论下的截断参数。数值与应用试验结果表明,本文方法确定的截断参数可有效改善TSVD解算效果,是一种行之有效的截断参数确定方法。  相似文献