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The pharmaceutical effects of n-3 polyunsaturated fatty acids(n-3 PUFAs) as dietary nutrients on human health and diseases have gained much attention and are investigated for decades. Docosahexaenoic acid(DHA), eicosapentaenoic acid(EPA) and docosapentaenoic acid(DPA) are the three major n-3 PUFAs enriched in marine organisms, such as fish, shrimp, algae, and so on. It has been well known that n-3 PUFAs, especially DHA and EPA, are beneficial in reducing the risk of cardiovascular and cerebrovascular diseases. Accumulating evidence suggests that n-3 PUFAs might cure inflammatory diseases through several mechanisms, such as plasma membrane remodeling of lymphocytes, down-regulating pro-inflammatory cytokines, and alternating adhesion molecule expressions. Several molecular targets of n-3 PUFAs on immune-regulation have also been identified, such as GPR120(FFA4), protein kinase C(PKC), and PPAR-γ. However, it remains inconclusive if dietary n-3 PUFAs function the same both in vitro and in vivo based on cohort studies. This review will focus on the molecular targets and mechanisms of anti-inflammatory and immunomodulatory effects of n-3 PUFAs on human health and diseases, such as obesity, tumor, diabetes, and autoimmune diseases. 相似文献
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2013年青岛输油管道爆炸,大量石油污染了附近海岸。课题组采集了污染的沉积物样品,以原油为唯一碳源和能源,富集了四个石油降解菌群。生物多样性和群落分析表明,Luteibacter、Parvibaculum 和属于食烷菌科的一个属是降解菌群的主要优势菌,都属于变形菌门。从石油降解菌群中分离筛选,获得了9株具有不同16S rRNA基因序列的降解菌,分别属于8个属。重量法测定降解菌的石油降解率,其中5株的石油降解率大于30%。GC-MS分析结果表明,石油降解菌多倾向于降解烷烃,对多环芳烃的降解能力较差,其中5株细菌的烷烃降解率较大,仅1株菌D2对多环芳烃的降解率较大,其降解率在34.9%到77.5%。通过对高通量数据的分析,表明食烷菌属是菌群A和菌群E的主要降解菌群,其中筛选获得的菌株E4可能是菌群E的一株优势降解菌。本研究所筛选菌株证明了其石油降解潜力,为油污染海滩生物修复提供了菌株资源。 相似文献
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为提高耐压柱壳设计效率,设计了耐压柱壳参数化分析流程。研究了有限元分析所涉及的材料属性、载荷施加、边界条件设置等内容,确定了采用弧长法分析耐压柱壳稳定性。利用Python语言对于ABAQUS软件进行了二次开发,利用Isight软件实现了ABAQUS的集成,实现了耐压柱壳有限元分析模型的网格自动划分、自动分析计算等。选择样本点进行参数化分析,利用响应面模型对于样本点进行了拟合,得到了具有较高拟合精度、满足工程需要的近似模型,进行了设计变量的灵敏度分析。研究结果表明:参数化分析流程可实现耐压柱壳的自动分析、近似模型及灵敏度分析,可降低耐压柱壳分析难度,均可提高耐压柱壳设计效率。 相似文献
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When travelling, people are accustomed to taking and uploading photos on social media websites, which has led to the accumulation of huge numbers of geotagged photos. Combined with multisource information (e.g. weather, transportation, or textual information), these geotagged photos could help us in constructing user preference profiles at a high level of detail. Therefore, using these geotagged photos, we built a personalised recommendation system to provide attraction recommendations that match a user's preferences. Specifically, we retrieved a geotagged photo collection from the public API for Flickr (Flickr.com) and fetched a large amount of other contextual information to rebuild a user's travel history. We then created a model-based recommendation method with a two-stage architecture that consists of candidate generation (the matching process) and candidate ranking. In the matching process, we used a support vector machine model that was modified for multiclass classification to generate the candidate list. In addition, we used a gradient boosting regression tree to score each candidate and rerank the list. Finally, we evaluated our recommendation results with respect to accuracy and ranking ability. Compared with widely used memory-based methods, our proposed method performs significantly better in the cold-start situation and when mining ‘long-tail’ data. 相似文献
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注册测绘师制度作为保证测绘成果质量、强化法律责任和全面贯彻落实《中华人民共和国测绘法》的重要举措,对测绘企业乃至测绘地理信息行业都有着深远影响。本文试从人力资源管理的角度进行解读,分析注册测绘师制度对人力资源规划、岗位设置和人力资源供求关系的影响,并结合自身的工作经验和所思所想提出了特定项目试点执业、建立信息共享平台和实行绩效管理等执业建议,以实现注册测绘师、测绘企业和测绘地理信息行业的协同发展。 相似文献
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Valuation of lake and marsh wetlands ecosystem services in China 总被引：1，自引：0，他引：1
Wetlands are highly productive natural ecosystems, providing valuable goods and services. There is growing interest in transferring ecosystem service value from the existing wetlands studied to other wetlands ecosystems at a large geographic scale. The benefit transfer method uses the known values from wetlands to predict the value of other wetland sites. This methodology requires only limited time and resources. The present study calculated the value of the ecological services provided by lake and marsh wetlands in China in terms of biodiversity indices, water quality indices and economic indices. Basic data on wetlands were obtained through remote sensing images. The results show that: 1) The total ecosystem service value of the lake and marsh wetlands in 2008 was calculated to be 8.1841 × 1010 United States Dollars(USD), with the marsh and lake wetlands contributing 5.6329 × 1010 and 2.5512 × 1010 USD, respectively. Values of marsh ecosystem service were concentrated in Heilongjiang Province(2.5516 × 1010 USD), Qinghai Province(1.2014 × 1010 USD), and Inner Mongolia Autonomous Region(1.1884 × 1010 USD). The value of the lakes were concentrated in Tibet Autonomous Region(6.223 × 109 USD), Heilongjiang(5.810 × 109 USD), and Qinghai(5.500 × 109 USD). 2) Waste treatment and climate regulation services contributed to 26.29% and 24.74% respectively, of the total ecosystem service value of the marsh wetlands. Hydrological regulation and waste treatment contributed to 41.39% and 32.75%, respectively, of the total ecosystem service value of the lake wetlands. 3) The total ecological service value of the lake and marsh wetlands was 54.64% of the total service value of natural grassland ecosystems and 30.34% of the total service value of forests ecosystems in China. 相似文献
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He Yujun Wang Bin Huang Wenyu Xu Shiming Wang Yong Liu Li Li Lijuan Liu Juanjuan Yu Yongqiang Lin Yanluan Huang Xiaomeng Peng Yiran 《Climate Dynamics》2020,54(7):3541-3559
Climate Dynamics - A new coupled data assimilation (CDA) system based on dimension-reduced projection four-dimensional variational data assimilation (DRP-4DVar) for decadal predictions is developed... 相似文献
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五道沟金矿位于太平岭金-铜多金属成矿带,矿体呈脉状赋存于下二叠统双桥子组碳质板岩中,并严格受NE向断裂控制。根据野外观察和岩相学研究,将五道沟金矿成矿划分为早期石英阶段、石英-黄铁矿阶段、石英-碳酸盐阶段3个阶段,其中石英-黄铁矿阶段为主要成矿阶段。石英流体包裹体显微测温和拉曼光谱分析表明,金成矿期流体为中低温、低盐度的含CO2流体。氢氧同位素分析表明,成矿流体是岩浆水和大气降水的混合流体。黄铁矿微量元素特征表明矿区内黄铁矿为岩浆热液成因;矿石硫同位素数据显示其具有岩浆硫和地层硫的混合特征。铅同位素组成图上,矿石铅、围岩铅和岩浆岩铅三者呈线性关系,具有同源特征,矿石中207Pb/204Pb和208Pb/204Pb值明显高于围岩的相应值,暗示了矿石铅为围岩铅淋滤产物。矿石同位素特征表明双桥子组碳质板岩应为金矿矿源层。综合矿床地质特征、流体包裹体和H-O-S-Pb同位素分析,认为五道沟金矿为造山型金矿。 相似文献
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根据2009年2月对三门湾海域的环境质量调查结果,结合海洋环境功能区划对该海域环境质量现状进行了评价与分析;并综合分析了水质中富营养化程度,沉积物中重金属的富集程度及潜在生态危害效应。结果表明:该海域水质除无机氮和Hg外其他环境因子基本符合功能区相应的海水水质标准,水质状况尚好。61.5%站位的富营养化指数大于1,表明该海区富营养化程度较高;该海域沉积物除少数站位的Cu、Cr外,其他环境因子的含量均达标,底质环境状况良好。各站位潜在生态危害系数均远小于150,说明三门湾海域沉积物中重金属的潜在生态危害属于轻微危害范围。 相似文献