An aromatase inhibitor and tamoxifen decrease plasma levels of o,p'-DDT and its metabolites in Nile tilapia (Oreochromis niloticus)     

Leaños-Castañeda O  Gold-Bouchot G  Van Der Kraak G  Lister A  Ceja-Moreno V  Simá-Alvarez R 《Marine environmental research》2004,58(2-5):337-342

The objective of this study was to determine if tamoxifen or an aromatase inhibitor (4-hydroxyandrostenedione; 4-OHA) affected plasma concentrations of o,p' -DDT and its metabolites, o,p'-DDD and o,p'-DDE, in mature tilapia. Male and female tilapia were injected 6 times intraperitoneally with o,p'-DDT (40 mg/kg) alone or in combination with 4-OHA (2 mg/kg) over a 12 day period. An additional group of male fish was injected with tamoxifen (5 mg/kg) plus o,p'-DDT. At the end of the treatment period, plasma samples were extracted and analyzed by GC/ECD. Females injected only with o,p'-DDT had significantly higher levels of o,p'-DDT compared with males. Interestingly, females and males treated concomitantly with o,p'-DDT and 4-OHA or tamoxifen had significantly lower concentrations of plasma o,p'-DDT (about 50%) compared with fish treated with only o,p'-DDT. These initial results suggest that an interaction between endocrine-active compounds occurs in vivo in tilapia and may involve alterations in metabolism of o,p'-DDT.  相似文献   

山西铝土矿床成矿物质来源     

卢静文  彭晓蕾  徐丽杰 《吉林大学学报(地球科学版)》1997,(2)

山西铝土矿矿石中鲕、豆、碎屑等组构均具红土性质，结合化学成分特征、稀土元素特征、氧同住素特征、锆石等副矿物特征及含矿岩系底部岩层与下伏中奥陶纪灰岩关系和矿床分布与古陆、古岛的依赖关系等方面分析，铝土矿的成矿物质多是异源的，多为古陆上的铝硅酸盐岩红土风化产物，经流水以机械碎屑形式被搬运至海盆，沉积成矿  相似文献   

Web Use in Geographical and Environmental Education: An International Survey at the Primary and Secondary Level   总被引：2，自引：0，他引：2  

Lea Houtsonen  Ilta-Kanerva Kankaanrinta  Antti Rehunen 《GeoJournal》2004,60(2):165-174

This article aims to study Web use and Web-based co-operation and collaboration in geographical and environmental education at the primary and secondary level around the world. Recent trends and future opportunities and challenges are taken into account. The theoretical part of the study considers Web use and different forms of Web-based co-operation. Web use and co-operation in education are classified as co-operative learning, collaborative learning or communal learning. Web use in geographical and environmental education is noted to be growing in significance. Web-based co-operation at any level of intensity is associated with many opportunities and challenges. The empirical part of this study involves a survey of geographical and environmental education researchers in various countries about their views of Web use in education. The results of this survey indicate that the Web in general finds minimal use in geographical and environmental education. As access to the Web is limited and only some pupils can use it, co-operation, particularly collaborative learning on the Web, is still rare in geographical and environmental education. The most often used application is e-mail. Researchers recognise the potential of the Web to enhance local, national and international co-operation, and to facilitate a better understanding of geographical and environmental issues at the grass-root level. Web-based learning can also help to increase and deepen the pupils' cultural understanding. Before that, however, problems in access, costs and teacher training must be solved. This revised version was published online in August 2006 with corrections to the Cover Date.  相似文献   

Detecting the stepwise propagation of the Eastern Sicily thrust belt (Italy): insight from thermal and thermochronological constraints     

Lea Di Paolo  Valerio Olivetti  Sveva Corrado  Luca Aldega  Maria Laura Balestrieri  Rosanna Maniscalco 《地学学报》2014,26(5):363-371

An extensive dataset of vitrinite reflectance, FTIR parameters on organic matter, illite content in mixed layers illite‐smectite, apatite fission tracks and U‐Th/He dating has been used to reconstruct the stepwise propagation of the Eastern Sicily fold‐and‐thrust belt during Late Palaeogene and Neogene times. The results indicate that the fold‐and‐thrust belt is divisible into two levels of thermal maturity. These levels consist of a less evolved level of thermal maturity that records limited sedimentary burial and minor heating, and a more evolved level of thermal maturity that indicates tectonic burial and exhumation at different times. Deformation and exhumation of shallowly buried units are linked to wedge forward propagation by low‐angle thrusts, whereas the evolution of deeply buried units is associated with tectonic imbrications by duplex formation and steep thrusts. The two tectonic styles alternate during evolution of the fold‐and‐thrust belt under low erosion rates.  相似文献   

Sustaining trajectories towards Sustainability: Dynamics and diversity in UK communal growing activities     

Rebecca White  Andrew Stirling 《Global Environmental Change》2013,23(5):838-846

Civil society is a critical arena both for exploring Sustainability itself and for sustaining trajectories towards it through innovation, experimentation and debate. Innovations can be mould breaking and can challenge local institutions. Concurrently, initiatives may be fragile due to the development of new working relationships, reliance on voluntary labour and goodwill, and dependence on grant funding. Here we examine different aspects of what it takes to sustain grassroots trajectories for ‘communal growing’, given the pressures that groups and intermediary organisations practicing and supporting this activity experience, and the consequential need to build qualities like ‘resilience’. Attending carefully to the definition of this otherwise slippery concept, a particular focus is given to how contrasting aspects of temporality and agency lead to divergent constructions of ‘resilience’ and strategies for sustaining growing. We draw on fieldwork that explores the practice and support of communal growing in East Sussex, England, and directly associated activities at a national level.We find important interdependencies between communal growing projects and the intermediary organisations supporting them. Additionally there is huge diversity within and between both projects and the organisations that support them, including with respect to the ends to which growing is seen as a means. These ends link growing initiatives – both antagonistically and synergistically – to food, education and health systems. This diversity can be seen positively as: a source of innovation; facilitating the open and bottom up nature of growing; and, enabling the securing of greater financial support for the endeavour. What is less clear is how this plays into framing and configuring communal growing specifically in relation to achieving a more Sustainable and localised food system. We discuss the conceptual and methodological implications of these empirically derived observations with regards future research on grassroots innovations.  相似文献   

Fault trace complexity, cumulative slip, and the shape of the magnitude-frequency distribution for strike-slip faults: a global survey   总被引：4，自引：0，他引：4  

Mark W. Stirling  Steven G. Wesnousky  Kunihiko Shimazaki 《Geophysical Journal International》1996,124(3):833-868

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The Byers Basin: Jurassic-Cretaceous tectonic and depositional evolution of the forearc deposits of the South Shetland Islands and its implications for the northern Antarctic Peninsula     

Joaquin Bastias  Mauricio Calderón  Lea Israel  Francisco Hervé  Richard Spikings  Robert Pankhurst 《International Geology Review》2020,62(11):1467-1484

ABSTRACT

This paper addresses the Jurassic–Cretaceous stratigraphic evolution of fore-arc deposits exposed along the west coast of the northern Antarctic Peninsula. In the South Shetland Islands, Upper Jurassic deep-marine sediments are uncomformably overlain by a Lower Cretaceous volcaniclastic sequence that crops out on Livingston, Snow and Low islands. U-Pb zircon ages are presented for the upper Anchorage Formation (153.1 ± 1.7 Ma) and the Cape Wallace granodiorite of Low Island (137.1 ± 1.7 Ma) as well as ⁴⁰Ar/³⁹Ar ages of 136–139 Ma for Low Island andesites. Data are also presented for a U-Pb age of 109.0 ± 1.4 Ma for the upper volcanic succession of Snow Island. In combination with published stratigraphy, these data provide a refined chrono- and litho-stratigraphic framework for the deposits herein referred to as the Byers Basin. Tentative correlation is explored with previously described deposits on Adelaide and Alexander islands, which could suggest further continuation of the Byers Basin towards the south. We also discuss possible correlation of the Byers Basin with the Larsen Basin, a sequence that shows the evolution of foreland to back-arc deposits more or less contemporaneously with the fore-arc to intra-arc evolution of the Byers Basin.  相似文献   

Some effects of pollutants on the behaviour of the bivalve Tellina tenuis     

E.A. Stirling 《Marine pollution bulletin》1975,6(8):122-124

Prediction of safe levels of effluent discharge have in the past been largely based on the results of short term acute toxicity tests (LC_{5 0}s). Such tests are usually carried out in unnatural experimental conditions, and in consequence the results are of only limited value. There is a need to enlarge the concept of the routine bioassay test to include quantitative measurement of the effects of pollutants on behaviour, physiology and metabolism. This paper describes a simple rapid bioassay test in which the effect of pollutants on the burrowing of the bivalve Tellina tenuis has been used as a quantitative measure of pollutant effect.  相似文献   

“Pandora box” — Matrix in the calculus of observations     

Lubomír Kubáček  Lea Bartalošová  Ján Pecár  Reviewer F. Charamza 《Studia Geophysica et Geodaetica》1977,21(3-4):227-235

Summary If the condition R(A)=k(n), whereA is the design matrix of the type n × k and k the number of parameters to be determined, is not satisfied, or if the covariance matrixH is singular, it is possible to determine the adjusted value of the unbiased estimable function of the parameters f(), its dispersion D( (x)) and ² as the unbiased estimate of the value of ² by means of an arbitrary g-inversion of the matrix . The matrix , because of its remarkable properties, is called the Pandora Box matrix. The paper gives the proofs of these properties and the manner in which they can be employed in the calculus of observations.  相似文献   

Book review     

Mary-Anne Lea 《Polar research》2007,26(1):88-89

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