Studies on Antineoplastic Constituents from Marine Bryozoan Bugula neritina Inhabiting South China Sea (Ⅲ): Isolation and Structural Elucidation of Bryostatins 10, 11 and 18     

林厚文  易杨华  姚新生  吴厚铭 《海洋通报(英文版)》2001,3(1)

Six active compounds are isolated from the marine bryozoan Bugula neritina,inhabiting the Nanwan Bay in the South China Sea, using the bioassay-guided method with a combination of extraction and partitionation with suitable solvents as well as multiple column chromatographies ( Sephadex LH-20, ODS and preparative HPLC).Their structures are identified as known bryostatins-bryostatins 4, 5, 6, 10, 11 and 18 through intensive analysis of the data of high resolution 2D NMR (600 MHz, DQF-COSY,TOCSY, HMQC and ROESY) and ESI-MS. Among them, bryostatins 10, 11 and 18 are for the first time obtained from this bryozoan in the South China Sea and they show significant antineoplastic activities in vitro.  相似文献   

近年来海洋生物活性多肽的研究概况与展望   总被引：3，自引：0，他引：3  

于荣敏  严春艳  曲红艳  姚新生 《海洋通报》2004,23(3):87-93

海洋是地球上资源最丰富的领域，海洋生物是新型肽类生物活性物质的重要来源。科学研究证明，许多海洋多肽具有抗肿瘤、抗艾滋病、抗真菌、抗病毒、防治心脑血管疾病及免疫调节等药理活性。本文简要介绍了近5a来国内外对海洋生物活性肽的研究概况，并进行了概括性展望。  相似文献