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We extracted marine low-temperature lysozyme (MLTL), a novel lysozyme, from a marine microorganism through fermentation. Our
previous study suggested that a low molecular weight (16 kDa) may exert anti-tumor activity through antiangiogenesis. In this
study, we extracted a high weight (39 kDa) and investigated its antiangiogenic activity in vivo and in vitro. Using zebrafish embryos as an in vivo study model, we found that treatment with MLTL significantly inhibited the growth of subintestinal vessels (SIVs) in a dose-dependent
manner and that 400 μg/ml MLTL was sufficient to block the growth of SIVs. An in vitro study conducted using human umbilical vein endothelial cells (HUVECs) revealed that MLTL suppressed the proliferation, migration
and tube formation of HUVECs in a dose-dependent manner. Interestingly, assays by flow cytometry and DNA electrophoresis indicated
that MLTL was able to induce apoptosis of HUVECs. Moreover, further study demonstrated that the disruption of intracellular
Ca2+ homeostasis may play an important role in MLTL induced apoptosis of HUVECs. Taken together, the results of this study demonstrate
for the first time that MLTL inhibits angiogenesis through its pleiotropic effects on vascular endothelial cells and induces
apoptosis through regulation of cellular Ca2+ levels. The results of this study also revealed a possible mechanism underlying the antiangiogenic effect of MLTL and suggested
that MLTL may be a promising new antiangiogenic agent for use in cancer therapy. 相似文献
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采用目前普遍接受的基于初动符号和振幅比的HASH方法,计算了2008年10月至2018年10月张渤带西段中小地震震源机制解;在获得震源机制解的基础上,进一步利用震源机制解一致性参数研究了涿鹿4.3级地震前后的应力场变化特征。结果表明:该区域震源机制解以正断型和走滑型为主,逆冲型次之,涿鹿4.3级地震后走滑型地震较震前略有上升,表明该区域的剪切作用增强;主压应力轴方位大致为NEE-SWW,主张应力轴为SSENNW向;涿鹿4.3级地震发生在震源机制一致性参数的低值边缘附近,发震时间也在一致性参数的低值时段。 相似文献
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在植被发育的秦巴地区，应用植物地球化学测量法寻找金矿取得了初步的研究成果，用来找金矿的有效指示植物有：槲、栎、板栗（雄株）和马桑等。这些植物作为找矿标志，可明显指示出位于厚覆盖层之下的金矿体。据此，可圈定出找金的有利地段． 相似文献
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天津市西郊富硒土壤地球化学特征和成因分析 总被引：2，自引：0，他引：2
为了查明天津市西郊富硒土壤的地球化学特征和成因,开展针对土壤-大气-水体-作物的调查研究工作。结果显示:研究区土壤Se元素平均值为0.66 mg/kg,是天津市土壤背景值的2.87倍,有83%为富硒土壤。土壤Se元素被颗粒状有机物质大量固定和吸附,富集于耕层土壤。耕层土壤Se元素与粗砂粒、细砂粒、Pb、Zn、Cd、Cu、Hg、N、P等指标显著正相关,与黏粒、粉粒、Na、K、Mg、As、CEC、pH等指标显著负相关。农民大量持续使用富含Se的有机肥是土壤Se元素显著富集的主要原因,占输入总通量的86.55%;大气沉降是次要原因,占13.35%。研究区土壤Se元素的年增加量为0.019 mg/kg,按2.77%的速度逐年增长。 相似文献
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陕西山阳西部地区的中酸性小岩体,以往多以“三五成群,东西成串”的自然分布形态进行分群划带,我们通过工作,依据岩体的岩石化学、地球化学和基本地质特征,认为以凤镇断裂为界,进行岩带划分,似乎更为适宜。现仅将相关资料整理成文,就教于研究和工作的同志们。 相似文献
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