Prevalence and risk assessment of antibiotics in riverine estuarine waters of Larut and Sangga Besar River,Perak     

Low  Kyleyoung  Chai  Layching  Lee  Choonweng  Zhang  Gan  Zhang  Ruijie  Vahab  Vaezzadeh  Bong  Chuiwei 《中国海洋湖沼学报》2021,39(1):122-134

Antibiotics released into the environment through anthropogenic activities exert selective pressure,driving bacteria towards increasing antimicrobial resistance.The prevalence of antibiotics and the ecological risks posed in the riverine estuarine of Larut River and Sangga Besar River,which included wastewater effluents from hospital,zoo,and poultry slaughterhouse sources were investigated.Solid phase extraction(SPE) followed by high-performance liquid chromatography tandem mass chromatography(HPLC-MS/MS) were used to extract and quantify the antibiotic residues from 22 antibiotics belonging to six major antibiotic classes(sulfonamide,macrolide,fluoroquinolone,phenicol,trimethoprim,and tetracycline).Sixteen antibiotic residues were detected with concentrations ranging from limit of detection(LOD) to 1 262.3 ng/L.Fluoroquinolones and macrolides were the most frequently detected compounds.Erythromycin,clarithromycin and ofloxacin detected in hospital and zoo effluents posed a high risk to algae while tetracycline had low to medium ecological risks toward all the relevant organisms from aquatic environments(algae,invertebrate Daphnia magna,and fish).  相似文献