基于网络药理学与分子对接探究连脂清肠汤治疗溃疡性结肠炎的作用机制          下载免费PDF全文

崔松香  毛银枫  陆为民 《应用海洋学学报》2022,38(11):160

目的：应用网络药理学与分子对接技术探究连脂清肠汤（LQD）治疗溃疡性结肠炎（UC）的作用机制。方法：利用TCMSP和TCMID数据库收集LQD的活性成分及靶点,通过GeneCard、OMIM及TTD数据库获取UC疾病靶点,将药物与疾病靶点匹配得到共同靶点,使用Cytoscape 软件构建“中药-成分-靶点-疾病”网络图,将关键靶点导入STRING平台构建PPI网络,并用DAVID数据库对关键靶点进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析,利用Auto Dock Tools对筛选所得活性成分与靶点蛋白进行分子对接验证。结果：获得LQD有效活性成分123种,LQD作用靶点216个,UC靶点1189个,共同靶点117个。LQD治疗UC的主要活性成分包括槲皮素、山柰酚、柚皮素、甘草查尔酮a、芒柄花黄素等。核心靶基因包括信号转录活化因子3（STAT3）、转录因子激活蛋白1（JUN）、丝氨酸/苏氨酸激酶1（AKT1）、核转录因子-κB p65（RELA）、白细胞介素-6（IL-6）等。GO功能主要包括RNA聚合酶Ⅱ启动子转录的正调控、凋亡过程的负调控、细胞核、细胞溶质、细胞质、蛋白结合、酶结合等。KEGG通路主要有癌症通路、TNF信号通路、PI3K-Akt信号通路等。分子对接结果表明核心成分与核心靶点结合性较好。结论：LQD治疗UC具有多组分、多靶点和多通路的特点。  相似文献   

空间视角下城乡物流网络的内涵、构成要素与研究框架     

王钊  李涛  黄文杰 《地理科学》2023,43(1):82-91

地理学视角的物流网络研究已成为物流科学领域的热点方向。从地理学的空间视角出发,在明确城乡物流网络理论来源和相关概念的基础上,对城乡物流网络的内涵、构成及研究框架进行梳理。基于研究,首先给出了城乡物流网络的定义,认为城乡物流网络的本质是旧的城市物流网络和乡村物流网络在空间上的延伸、衔接和提效。其次,从空间视角将城乡物流网络分解为节点、连线和域面3要素,指出网络各要素均出现了功能强化和更新,如节点的管理、衔接和经济社会功能强化;连线的联结功能和平衡功能出现,域面的协同组织、动态调整功能突出。最后,遵循地理学“格局-过程-机理-决策”的科学逻辑,提出“数据采集与融合、要素映射与解析、时空比较与分析、机理探究与优化”4个模块的城乡物流网络分析框架,为深刻揭示城乡物流网络结构及其演化机理提供基础。进一步指出未来应探讨城乡物流节点、连线、域面及网络的地区类型、区域适宜性及要素间相互作用机制,提炼适应不同区域、能有效提升要素流通效应的多尺度空间组织模式,加强对城乡要素流通系统的科学认知,科学支撑城乡地域融合发展实践。  相似文献   

UPLC-MS metabolomics provides insights into the differences between black- and white-shelled Pacific oysters Crassostrea gigas     

Chen  Xi  Jiang  Qiuyun  Song  Hongce  Li  Lingling  Xie  Chaoyi  Huang  Baoyu  Liu  Yaqiong  Zhang  Meiwei  Wei  Lei  Wang  Xiaotong 《中国海洋湖沼学报》2021,39(1):340-349

Journal of Oceanology and Limnology - A variety of shell colors are one of the most fundamental characteristics of molluscs, which have importantly ecological and economic significance. The Pacific...  相似文献   

Retrieving multi-scale climatic variations from high dimensional time-series MODIS green vegetation cover in a tropical/subtropical mountainous island     

CHANG Chung-te  WANG Hsueh-ching  HUANG Cho-ying 《山地科学学报》2014,11(2):407-420

【Title】
There are knowledge gaps in our understanding of vegetation responses to multi-scale climate-related variables in tropical/subtropical mountainous islands in the Asia-Pacific region. Therefore, this study investigated inter-annual vegetation dynamics and regular/irregular climate patterns in Taiwan. We applied principal component analysis （PCA） on 11 years （2001~2011） of high-dimensional monthly photosynthetically active vegetation cover （PV） derived from the Moderate Resolution Imaging Spectroradiometer （MODIS） and investigated the relationships between spatiotemporal patterns of the eigenvectors and loadings of each component through time and multi-scale climate-related variations. Results showed that the first five components contributed to 96.4% of the total variance. The first component （PC1, explaining 94.5% of variance） loadings, as expected, were significantly correlated with the temporal dynamics of the PV （r = 0.94）, which was mainly governed by regional climate. The temporal loadings of PC2 and PC3 （0.8% and 0.6% of variance, respectively） were significantly correlated with the temporal dynamics of the PV of forests （r = 0.72） and the farmlands （r = 0.80）, respectively. The low-order components （PC4 and PC5, 0.3% and 0.2% of variance, respectively） were closely related to the occurrence of drought （r = 0.49） and to irregular ENSO associated climate anomalies （r = -0.54）, respectively. Pronounced correlations were also observed between PC5 and the Southern Oscillation Index （SOI） with one to three months of time lags （r = -0.35 ~ -0.43, respectively）, revealing biophysical memory effects on the time-series pattern of the vegetation through ENSO-related rainfall patterns. Our findings reveal that the sensitivity of the ecosystems in this tropical/subtropical mountainous island may not only be regulated by regional climate and human activities but also be susceptible to large-scale climate anomalies which are crucial and comparable to previous large scale analyses. This study demonstrates that PCA can be an effective tool for analyzing seasonal and inter-annual variability of vegetation dynamics across this tropical/subtropical mountainous islandin the Pacific Ocean, which provides an opportunity to forecast the responses and feedbacks of terrestrial environments to future climate scenarios.  相似文献   

Linking Tarim Basin sea retreat (west China) and Asian aridification in the late Eocene   总被引：1，自引：0，他引：1  

R. Bosboom  G. Dupont‐Nivet  A. Grothe  H. Brinkhuis  G. Villa  O. Mandic  M. Stoica  W. Huang  W. Yang  Z. Guo  W. Krijgsman 《Basin Research》2014,26(5):621-640

The Tarim Basin in western China formed the easternmost margin of a shallow epicontinental sea that extended across Eurasia and was well connected to the western Tethys during the Paleogene. Climate modelling studies suggest that the westward retreat of this sea from Central Asia may have been as important as the Tibetan Plateau uplift in forcing aridification and monsoon intensification in the Asian continental interior due to the redistribution of the land‐sea thermal contrast. However, testing of this hypothesis is hindered by poor constraints on the timing and precise palaeogeographic dynamics of the retreat. Here, we present an improved integrated bio‐ and magnetostratigraphic chronological framework of the previously studied marine to continental transition in the southwest Tarim Basin along the Pamir and West Kunlun Shan, allowing us to better constrain its timing, cause and palaeoenvironmental impact. The sea retreat is assigned a latest Lutetian–earliest Bartonian age (ca. 41 Ma; correlation of the last marine sediments to calcareous nannofossil Zone CP14 and correlation of the first continental red beds to the base of magnetochron C18r). Higher up in the continental deposits, a major hiatus includes the Eocene–Oligocene transition (ca. 34 Ma). This suggests the Tarim Basin was hydrologically connected to the Tethyan marine Realm until at least the earliest Oligocene and had not yet been closed by uplift of the Pamir–Kunlun orogenic system. The westward sea retreat at ca. 41 Ma and the disconformity at the Eocene–Oligocene transition are both time‐equivalent with reported Asian aridification steps, suggesting that, consistent with climate modelling results, the sea acted as an important moisture source for the Asian continental interior.  相似文献   

汉江上游3200-2800aBP特大古洪水重建研究(英文)     

查小春  黄春长  庞奖励  周亚利 《地理学报(英文版)》2014,24(3):446-456

Palaeoflood hydrology study is a leading subject in global change study. Through field investigation in the upper reaches of Hanjiang River, palaeoflood slackwater deposits(SWD) were found in the bedrock gorges of the Yunxi reach. The results of field observation, laboratory analysis including particle-size distribution and magnetic susceptibility, and comparison with modern flood deposits, the SWD were identified as the most typical Holocene palaeoflood deposits of the Hanjiang River. By using stratigraphic correlation and OSL dating method, the palaeoflood event was dated to be 3200–2800 a BP at the turn from the middle to late Holocene. According to the palaeoflood peak stage and hydraulic parameters, the peak discharges of the palaeoflood were reconstructed as 48,830–51,710 m3/s by using the slope-area method. At same time, the flood peak discharges of 1983, 2005 and 2010 severe floods were reconstructed with the same method and hydraulic parameters in the same cross section. The error between the reconstructed and gauged discharges was 1.99%–4.21%. This showed that the reconstructed palaeoflood peak discharges were reliable. The flood peak discharge-frequency relationship at 10,000-year time scale was established by a combination of the gauged flood, historical flood and palaeoflood hydrological data. These results are very important for hydraulic engineering and flood mitigation on the Hanjiang River.  相似文献   

Radiative forcing over China due to albedo change caused by land cover change during 1990–2010     

Jun Zhai  Ronggao Liu  Jiyuan Liu  Guosong Zhao  Lin Huang 《地理学报(英文版)》2014,24(5):789-801

Land cover change affects surface radiation budget and energy balance by chang- ing surface albedo and further impacts the regional and global climate. In this article, high spatial and temporal resolution satellite products were used to analyze the driving mechanism for surface albedo change caused by land cover change during 1990-2010. In addition, the annual-scale radiative forcing caused by surface albedo changes in China＇s 50 ecological regions were calculated to reveal the biophysical mechanisms of land cover change affecting climate change at regional scale. Our results showed that the national land cover changes were mainly caused by land reclamation, grassland desertification and urbanization in past 20 years, which were almost induced by anthropogenic activities. Grassland and forest area decreased by 0.60% and 0.11%, respectively. The area of urban and farmland increased by 0.60% and 0.19%, respectively. The mean radiative forcing caused by land cover changes during 1990-2010 was 0.062 W/m2 in China, indicating a warming climate effect. However, spatial heterogeneity of radiative forcing was huge among different ecological regions. Farmland conversing to urban construction land, the main type of land cover change for the urban and suburban agricultural ecological region in Beijing-Tianjin-Tangshan region, caused an albedo reduction by 0.00456 and a maximum positive radiative forcing of 0.863 WIm2, which was presented as warming climate effects. Grassland and forest conversing to farmland, the main type of land cover change for the temperate humid agricultural and wetland ecological region in Sanjiang Plain, caused an albedo increase by 0.00152 and a maximum negative radiative forcing of 0.184 W/m2, implying cooling climate effects.  相似文献   

土壤氮、盐浓度对盐角草(Salicornia europaea)生长发育及氮素吸收的影响   总被引：1，自引：0，他引：1  

尹海龙  田长彦  任婧  陈春秀  黄建 《中国沙漠》2014,34(5):1277-1284

以盐生植物盐角草(Salicornia europaea)为材料,以NaCl模拟不同盐度环境,盆栽试验了氮(0.3g·kg-1,N1;0.6g·kg-1,N2;1.2g·kg-1,N3;2.4g·kg-1,N4)、盐(2.5g·kg-1,S1;5.0g·kg-1,S2;7.5g·kg-1,S3)处理对其生长发育及氮素吸收利用的影响。结果表明:(1)不同盐度下施氮均可以显著促进盐角草的生长,地上部干质量均在N2处理下达到最大,而株高均在N1时达到最高,且施氮对盐角草生长的影响与盐度有关;(2)不同盐度环境下施氮所能达到的最高干物质产量及最高施氮限量不同,表现为S3S1S2,随着施氮量的增加,氮素生产力与氮素农学利用效率均表现出下降的趋势;(3)施氮显著增加了盐角草各器官含氮量及氮吸收量,同一施氮水平下盐角草各器官含氮量及氮吸收量均表现为同化枝茎根;(4)同一施氮水平下,随着盐度的增加,盐角草同化枝渗透势显著下降,同一盐度环境下,随着施氮量的增加,同化枝渗透势呈现出下降趋势,渗透调节能力增大;(5)3个盐度环境下,施氮均增加盐角草同化枝光合色素含量,从而提高光合效率,增强其对盐渍环境的适应能力。  相似文献   

北冰洋西部表层沉积物矿物学特征及其物质来源          下载免费PDF全文

董林森  石学法  刘焱光  方习生  陈志华  王春娟  邹建军  黄元辉 《极地研究》2014,26(1):58-70

对北冰洋西部79个表层沉积物样品进行了全岩X射线衍射矿物组成分析,结合洋流和地质背景,探讨各矿物分区的物质来源。矿物组合分区表明研究区物质来源变化较为复杂:(1)在楚科奇海的中部靠近白令海峡处长石含量很高,主要是阿纳德尔流携带的来自阿纳德尔河的沉积物;在楚科奇海的西侧的长石含量也较高,且与其他矿物组合分区相比,角闪石含量较高,这是因为受阿纳德尔流和东西伯利亚沿岸流的双重影响,沉积物来自西伯利亚陆地的一些高含长石的火山岩及沉积岩等。在楚科奇海的东侧,石英含量很高,来源为阿拉斯加沿岸流携带的育空河及卡斯奎姆河的沉积物。在阿拉斯加北部,碳酸盐岩和石英含量高,这与马更些河搬运的沉积物有关;(2)北冰洋西部深水区中加拿大海盆的南端和中部方解石和白云石的含量较低,说明受波弗特环流携带的加拿大北极群岛的碳酸盐影响相对较小,且与其他矿物组合分区相比,云母含量最高,说明沉积物主要来源为来自拉普捷夫海的海冰沉积物;此外,一些黏土级细粒物质可能由大西洋中层水携带而来。深水区的其他海域以方解石和白云石含量高为特点,主要受波弗特环流的影响,来源主要为加拿大北极群岛的班克斯岛和维多利亚岛;此外,还受来自西伯利亚陆架,主要是拉普捷夫海沉积物的影响。  相似文献   

A new MODIS daffy cloud free snow cover mapping algorithm on the Tibetan Plateau     

XiaoDong Huang  XiaoHua Hao  QiSheng Feng  Wei Wang  TianGang Liang 《寒旱区科学》2014,(2):116-123

Because of similar reflective characteristics of snow and cloud, the weather status seriously affects snow monitoring using optical remote sensing data. Cloud amount analysis during 2010 to 2011 snow seasons shows that cloud cover is the major limitation for snow cover monitoring using MOD10A1 and MYD10A1. By use of MODIS daily snow cover products and AMSR-E snow wa- ter equivalent products （SWE）, several cloud elimination methods were integrated to produce a new daily cloud flee snow cover product, and information of snow depth from 85 climate stations in Tibetan Plateau area （TP） were used to validate the accuracy of the new composite snow cover product. The results indicate that snow classification accuracy of the new daily snow cover product reaches 91.7% when snow depth is over 3 cm. This suggests that the new daily snow cover mapping algorithm is suitable for monitoring snow cover dynamic changes in TP.  相似文献