基于网络药理学探究补阳还五汤治疗颈椎病的作用机制          下载免费PDF全文

王淑江  叶豪  龙胜利 《应用海洋学学报》2024,40(1):174

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。  相似文献   

Variational iteration solving method for El Nio phenomenon atmospheric physics of nonlinear model     

MO Jiaqi  *  WANG Hui  LIN Wantao  LIN Yihua. Anhui Normal University  Wuhu  China. Division of Computional Science  E-Institute of Shanghai Universities  Shanghai Jiaotong University Shanghai  China. Chinese Academy of Meteorological Sciences  Beijing  China. State Laboratory of Numerical Modeling for Atmospheric Sciences  Geophysical Fluid Dynamics  Institute of Atmosheric Physics  Chinese Academy of Sciences  Beijing  China 《海洋学报(英文版)》2005,(5)

1 IntroductionThe El Ni’o atmospheric physics oscillation is anabnormal phenomenon involved in the tropical Pacificocean- atmosphere interactions. Studies on the El Ni(ophenomenon are very attractive (Lin et al., 2000; Linet al., 2001, 2002; Wang, 2001; Feng et al., 2001;Feng et al., 2002; Liu et al., 2002; Wei and Chen,2003; Xie et al., 2002; Zhu et al., 2002; Pu et al.,2003; Gu et al., 2004; Yu and Liu, 2004). Lin and Mo(2004), Mo and Lin (2004) and Mo et al. (2004) alsostudied a s…  相似文献   

DISTRIBUTION, ECOLOGY AND RESOURCE CONSERVATION OF THE SPOTTED SEAL IN THE HUANGHAI AND BOHAI SEAS   总被引：2，自引：0，他引：2  

王丕烈 《海洋学报(英文版)》1986,5(1):126-133

The Phoca largha is found in the coastal waters of China from the Huanghai Sea and Bohai Sea to the northern part of East China Sea. Its breeding ground is situated in ice packs in the Liaodong Gulf., from about 40°10′ to 40°45′ N, from 121 °15′ to 122°E. At the breeding season, male and female seals in pairs form many family groups. The pup is born with white lanugo fur on ice packs in Liaodong Gulf during a period from January to the middle of February, and usually carried by its mother on her back to run away. However, from February to March, it could be caught around some islands in Bohai Strait. In recent years, these species resources have been reduced rapidly. It must be strengthened to protect the seals from extinction.  相似文献   

ELASTIC CLASSIFICATION OF MODIFIED WATER MASS IN SHALLOW SEA     

王凤钦  李凤岐  苏育嵩 《海洋学报(英文版)》1986,5(3):331-339

In this paper, the principle and steps for differentiating water masses by fuzzy cluster method are introduced, and a scalar formula based on Euclidean distance and a method for determining objectively the number of water masses by F-test are proposed. Consequently, a method and specific steps for differentiating modified water masses in shallow sea according to fuzzy elastic classification are given. Computation of the membership degree in which each sample belongs to every water mass determines conveniently and quantitatively the cores, boundaries of water masses and mixed zones. An example for the Huanghai Sea and East China Sea is shown and compared with previous results.  相似文献   

EQUATORIAL EASTERN PACIFIC SST AND SUBTROPICAL HIGH   总被引：1，自引：0，他引：1  

臧恒范  王绍武 《海洋学报(英文版)》1984,3(4):471-476

The variations of sea surface temperature (SST) on the east Pacific asd their relation to general atmospheric circulation are examined according to the data of the monthly mean SST and the 500mb level height for the period from January 1951 to December 1980.  相似文献   

南海北部含油气构造上方化探异常研究     

陈汉宗  周蒂  王平 《热带海洋学报》1997,(3)

在南海北部利用地球化学方法作为油气勘探的一种辅助手段。在6个航次中采集了沉积物、底层海水及海面大气样品，测定了近50种化探指标，并采用稳健统计方法进行了数据处理和异常圈定。化探结果在油气藏上方发现了清晰的、具不同指标组合的综合化探异常，与邻近空构造形成鲜明的对照。圈闭顶部的块状异常和圈闭周绿的环状、半环状异常是下伏油气藏的良好指示，而剖面上呈锯齿状、平面上呈线状的异常则与断裂带有关。实践表明，建立已知油气藏上方的化探异常模式及解剖已知空构造上方的地球化学特征对于指导本区或邻区的化探异常评价是十分必要的。  相似文献   

关于多项式特征值的条件数     

刘新国  王学锋 《中国海洋大学学报(自然科学版)》2004,34(5):913-917

Tisseur(2000)研究了非齐次多项式特征值问题的条件数，所得结果的不足是对无穷特征值必须另外处理；Declieu和Tisseur(2003)运用微分几何方法研究了齐次多项式特征值问题的条件数，所得结果的不足之处是与系数矩阵的尺度化(scaling)有关。这两种条件数都有各自的应用范围。本文基于投影尺度引入齐次多项式特征值问题的条件数，其优点是与系数矩阵的尺度化无关，因而也许会有较广泛的应用。  相似文献   

Sediment Transport in Rivers and Coastal Waters     

YANG  Shu-qing 《中国海洋工程》2003,17(4):527-540

Following Bagnold's approach, a relationship between sediment transport and energy dissipation is developed. The major assumption made in the study is that the near bed velocity plays a dominant role in the process of sediment transport. A general relationship between energy dissipation and sediment transport is first proposed. Then the equations for total sediment transport are derived by introducing the appropriate expression of energy dissipation rate under different conditions, such as open channel flows, combination of wave and current, as well as longshore sediment transport. Within the flows investigated, the derived relationships are fairly consistent with the available data over a wide range of conditions.  相似文献   

青岛市水环境污染及其防治对策     

赵秀春  初日邦  王成见  尚庆国 《海岸工程》2002,21(3):50-54

通过分析近几年青岛市地表，地下水水质监测资料，总结水环境污染地区分布规律，摸清水环境污染形成原因，对当前防污治污工作提出了对策建议。  相似文献   

半潜式超大浮体连接器动力特性的一种时间序列分析方法   总被引：1，自引：2，他引：1  

王璞  余澜 《海洋工程》2002,20(3):9-13

根据刚性模块弹性连接器 (RMFC)假设研究由 3个模块连接而成的半潜式超大浮体MobileOffshoreBase(MOB)的波浪载荷动力响应。模块和连接器动力响应根据时间序列法计算 ,这种方法包括海况模拟 ,波浪载荷计算和结构响应计算三个主要部分。通过对结构的适当简化 ,根据Airy波理论 ,Morrison公式以及流体中的结构运动方程、弹性连接器变形方程 ,计算求得MOB在不规则海况下的动力响应 ,并将其与相关文献中的结果进行比较 ,表明该方法有良好的精确性  相似文献