基于网络药理学和分子对接探讨左金丸治疗肝癌的作用机制          下载免费PDF全文

雷彩云  刘人杰  田立峰 《应用海洋学学报》2021,37(11):178

目的：运用网络药理学和分子对接方法探讨左金丸治疗肝癌的作用机制。方法：从TCMSP和BATMAN-TCM数据库获取左金丸的化合物及其相应靶点,检索GeneCards、OMIM和TTD 3个数据库获得肝癌的相关靶基因,取两者靶基因交集得到左金丸治疗肝癌的预测靶基因;运用Cytoscape 3.7.1软件构建左金丸-化合物-靶点-肝癌和PPI网络图;运用R软件对预测靶基因进行GO和KEGG富集分析;最后运用分子对接技术对关键化合物和靶点进行验证。结果：共获取左金丸35个化合物及173个相应靶点,左金丸与肝癌的共同靶点有103个。PPI结果表明AKT1、MAPK1、TP53、JUN和RELA可能为左金丸治疗肝癌的关键靶点。富集分析示左金丸可能通过乙型肝炎、卡波西肉瘤相关疱疹病毒感染、人巨细胞病毒感染、丙型肝炎、MAPK信号通路、肝癌等信号通路抗肝癌。分子对接结果示槲皮素和黄连素均能与AKT1和MAPK1稳定结合。结论：本研究初步揭示了左金丸通过多成分、多靶点、多通路治疗肝癌的作用机制,为后续左金丸治疗肝癌提供理论参考。  相似文献   

冷泉系统甲烷气体渗漏的声学特征及潜在环境效应     

尉建功  吴婷婷  邓希光  于宗泽  王力峰 《海洋学报(英文版)》2020,42(5):133-144

The amount of methane leaked from deep sea cold seeps is enormous and potentially affects the global warming,ocean acidification and global carbon cycle. It is of great significance to study the methane bubble movement and dissolution process in the water column and its output to the atmosphere. Methane bubbles produce strong acoustic impedance in water bodies, and bubble strings released from deep sea cold seeps are called "gas flares"which expressed as flame-like strong backscatter in the water column. We characterized the morphology and movement of methane bubbles released into the water using multibeam water column data at two cold seeps. The result shows that methane at site I reached 920 m water depth without passing through the top of the gas hydrate stability zone(GHSZ, 850 m), while methane bubbles at site II passed through the top of the GHSZ(597 m) and entered the non-GHSZ(above 550 m). By applying two methods on the multibeam data, the bubble rising velocity in the water column at sites I and II were estimated to be 9.6 cm/s and 24 cm/s, respectively. Bubble velocity is positively associated with water depth which is inferred to be resulted from decrease of bubble size during methane ascending in the water. Combined with numerical simulation, we concluded that formation of gas hydrate shells plays an important role in helping methane bubbles entering the upper water bodies, while other factors, including water depth, bubble velocity, initial kinetic energy and bubble size, also influence the bubble residence time in the water and the possibility of methane entering the atmosphere. We estimate that methane gas flux at these two sites is 0.4×10~6–87.6×10~6 mol/a which is extremely small compared to the total amount of methane in the ocean body, however, methane leakage might exert significant impact on the ocean acidification considering the widespread distributed cold seeps. In addition, although methane entering the atmosphere is not observed, further research is still needed to understand its potential impact on increasing methane concentration in the surface seawater and gas-water interface methane exchange rate, which consequently increase the greenhouse effect.  相似文献   

联合升降轨Sentinel-1A的地表形变监测技术研究          下载免费PDF全文

陈有东  何毅  张立峰  王文辉  唐源蔚 《海洋测绘》2020,40(4):59-64

河谷型、海岸带、海岛礁以及滩涂等区域地表形变信息的准确获取,迫切且关键。利用25景升轨和28景降轨Sentinel-1A数据,基于SBAS-InSAR技术,获取兰州城区2014年10月~2016年9月的地表沉降速率图和沿视线方向(line-of-sight,LOS)的时相位移量,探讨升降轨数据在河谷型城市地表形变监测中的适用性。结果表明:升降轨Sentinel-1A数据之间的时相位移量具有高度关联性,其中升轨数据在地形起伏较大区体现出良好的干涉性,而降轨数据在平坦区表现出较好的监测能力。兰州城区大部分区域处于稳定状态,但沙井驿、九州、小达坪、东岗、伏龙坪、西客站以及周边区域地表存在沉降趋势,最大沉降速率可达30 mm/年。联合升降轨Sentinel-1A数据监测河谷型、海岸带、海岛礁以及滩涂等区域地面沉降具有可行性和可靠性。  相似文献   

检验全球数值预报模式的相似度等指标   总被引：1，自引：1，他引：0  

朱娟  张立凤  张铭 《气象科学》2018,38(2):221-228

本文依照泛函形式并考虑了球面经纬网格的特点,定义了用于全球数值模式效果检验的指标:距离、距平相似度和倾向相似度,给出了相应的计算方法,并以全球WRF模式为例,检验了该模式的中期预报效果。所得结论如下:指标距离、距平相似度和倾向相似度物理意义明确,易于理论分析,考虑了球面经纬网格的特点,检验准确度高,具有普适性,能方便应用于球面经纬网格输出的数值模式检验。指标距离、距平相似度的检验结果分别与传统检验指标均方根误差、距平相关系数相一致,该指标还可直接用于向量场(如风场)的整体检验。本文的全球WRF模式所做的检验表明,对本文个例,该模式的全球500 hPa中期天气形势预报在第7 d及之内皆可用,5 d及之内预报效果更佳。  相似文献   

Extraction of basic trends of urban expansion in China over past 40 years from satellite images   总被引：2，自引：0，他引：2  

Qingke Wen  Zengxiang Zhang  Lifeng Shi  Xiaoli Zhao  Fang Liu  Jinyong Xu  Ling Yi  Bin Liu  Xiao Wang  Lijun Zuo  Shunguang Hu  Na Li  Minmin Li 《中国地理科学(英文版)》2016,26(2):129-142

If urban sprawl is to be avoided in China in the next ten years, it is not only crucial to understand the overall history, current status, and future trends of urban expansion there, but also these differences, and this is presently lacking. In this study, remotely sensed images with approximately 30 m spatial resolution were used to quantitatively assess the spatial and temporal patterns of urban expansion of 60 Chinese cities(1973–2013). Urban-expansion-process curves of the cities studied were drawn using annual expansion area as an indicator. Curve similarity analysis generated four basic process modes of urban expansion in China. These included cities that: 1) peaked around 2004 and then decelerated; 2) peaked around 2010 and then decelerated; 3) showed sustained acceleration, and 4) showed continued deceleration. Four basic process modes represented cities under different levels of development stage. Geographic location was found to be the most related characteristic to urban expansion process. Regional development policies at the national level in each region also showed highly temporal consistency with fluctuation characteristics of urban expansion process. Urban characteristic such as population size and administrative level were not found to be significantly related to urban expansion-process modes. Understanding the basic process-mode categories well is extremely important for future regional-balance planning and development of macroeconomic policies.  相似文献   

深空探测科学仪器研究进展     

高震宇  王民建  黄帆  宋爱国  朱利丰 《南京气象学院学报》2021,13(3):257-268

深空探测是对宇宙中地球以外的行星、卫星、小行星和彗星等星体或空间环境的探测活动.合理选择深空探测科学仪器,了解被测星体的物理及化学性质、地表地貌、动态特性以及有机物和水的存在,对人类了解地外水和生命信息、认识太阳系的起源和演化有着重要意义,是深空探测的重要任务.本文总结了深空探测的科学目标,介绍了近50年来典型深空探测任务中探测器所搭载的科学仪器及其特点,包括质谱仪、光谱仪、探地雷达和磁力计等,整理了其性能参数及面向的探测功能任务,最后讨论了深空探测科学仪器目前呈现出的小型化、低功耗、更强的环境适应能力和多仪器联合使用的发展趋势.  相似文献   

顾及人群集聚和情绪强度的城市综合活力评价及影响因素     

梁立锋  曾文霞  宋悦祥  邵振峰  刘秀娟 《地球信息科学学报》2022,24(10):1854-1866

城市活力的科学定量评估,能够为城市规划和协调发展提供重要依据,针对城市活力容易忽略居民情感的现状,本文选用百度热力图数据与微博情感分析结果,分别衡量人群集聚强度和情绪强度,并结合TOPSIS方法,提出一种顾及人群集聚和情绪强度的综合活力评估框架。从城市物理环境、经济环境和生态环境3个维度,选择8个关键影响因子,结合地理探测器空间分析方法,探讨影响因子对城市活力空间异质性的影响。结果表明：① 融合人群集聚强度和情绪强度的综合活力评估方法,能够较好反映城市活力空间分异格局;通过对典型样本区域分析,验证了本文提出的城市综合活力评价框架的有效性;② 城市POI密度对城市综合活力的解释力最显著,而植被覆盖度因子对城市综合活力的解释力最弱;但是植被覆盖度因子与其他因子的交互作用,对于城市活力空间异质性的影响力提升最为显著,表明植被覆盖度因子并不是直接作用于城市活力的空间异质性,而是通过耦合空间可达性、POI密度以及建筑密度等影响因子,间接影响城市综合活力的空间分异。  相似文献   

The Linkage between Midwinter Suppression of the North Pacific Storm Track and Atmospheric Circulation Features in the Northern Hemisphere     

Minghao YANG  Chongyin LI  Xin LI  Xiong CHEN  Lifeng LI 《大气科学进展》2022,39(3):502-518

The midwinter suppression(MWS) of the North Pacific storm track(NPST) has been an active research topic for decades. Based on the daily-mean NCEP/NCAR reanalysis from 1948 to 2018, this study investigates the MWS-related atmospheric circulation characteristics in the Northern Hemisphere by regression analysis with respect to a new MWS index, which may shed more light on this difficult issue. The occurrence frequency of the MWS of the upper-tropospheric NPST is more than 0.8 after the mid-1980 s. The MWS is accompanied by significantly positive sea-level pressure anomalies in Eurasia and negative anomalies over the North Pacific, which correspond to a strengthened East Asian winter monsoon. The intensified East Asian trough and atmospheric blocking in the North Pacific as well as the significantly negative low-level air temperature anomalies, lying upstream of the MNPST, are expected to be distinctly associated with the MWS. However, the relationship between the MWS and low-level atmospheric baroclinicity is somewhat puzzling.From the diagnostics of the eddy energy budget, it is identified that the inefficiency of the barotropic energy conversion related to the barotropic governor mechanism does not favor the occurrence of the MWS. In contrast, weakened baroclinic energy conversion, buoyancy conversion, and generation of eddy available potential energy by diabatic heating are conducive to the occurrence of the MWS. In addition, Ural blocking in the upstream region of the MNPST may be another candidate mechanism associated with the MWS.  相似文献   

随机介质的声散射(Ⅰ)——广义Born近似反演     

王宁  付圣雪  魏俊  赵犁丰 《中国海洋大学学报(自然科学版)》1998,(4)

运用泛函微分方法给出弱随机介质中散射问题的散射幅度Ｂｏｒｎ近似的推广形式。讨论了关于阻尼最小二乘法反演介质参数的各价相关函数的方法,并讨论具有有限支集势函数扰动的逆问题的唯一性,其结果对运用Ｎｅｗｔｏｎ法等数值方法有实际意义。  相似文献   

中期数值天气预报业务的回顾与展望   总被引：4，自引：3，他引：1  

付顺旗  张立凤 《气象科学》1999,19(1):104-110

本文回顾了近年来国内外中期数值天气预报业务的新进展,简略地介绍了当今国外（以欧洲中期天气预报中心为主）和我国中期数值天气预报业务系统。最后对未来中期数值天气预报的发展作一展望,指出其未来发展的主要方向。  相似文献