循着＂文本-思想-实践＂的梯度解读＂课程基本理念＂——以《义务教育地理课程标准》中＂课程基本理念＂的解读为例     

戴敖锁 《地理教学》2013,(24):32-34

以《义务教育地理课程标准》中“课程基本理念”的解读为例,从文本内涵、彰显思想、实践指导等三个梯度对“课程基本理念”进行了解读。首先揭示其文本内涵及其内在关系,发现“有用”和“开放”是其两大内涵,两者互为“以生为本”核心思想的表里,两者是目标和途径的关系;其次在教育思想层面解读,发现其映照着“生活教育”与“生命教育”、“终身教育”与“终身学习”的教育思想价值;最后指向教育实践解读,发现其蕴含着以学生发展为根本导向、以基于“问题”的生活化、乡土化地理案例为主要载体、以“自主＋合作式探究”为主要教学方式的地理教育教学实践体系。  相似文献   

酸雨环境下砌体结构地震易损性研究          下载免费PDF全文

郑山锁  程明超  马德龙  牛丽华  郑捷 《地震工程学报》2016,38(1):79-88

对4榀相同特性的砖墙进行不同程度的酸雨腐蚀试验及低周反复荷载试验,得出其在不同腐蚀循环次数下的滞回曲线。基于陆新征-曲哲恢复力模型对砖墙试件进行模拟分析,并与试验结果进行对比,验证得出三弹簧单元模型能够较准确预测砌体构件的滞回性能。利用三弹簧单元模型对不同腐蚀次数下砌体结构进行IDA分析,得出不同腐蚀次数下砌体结构的易损性曲线,通过对"小震"、"中震"、"大震"下结构失效概率的分析得出,酸雨腐蚀能够严重影响结构的力学性能,使得结构的抗震性能显著下降。  相似文献   

高强高性能混凝土损伤的细观数值演化          下载免费PDF全文

郑捷  左河山  陈景恒  曹文平  郑山锁 《地震工程学报》2016,38(5):745-750,769

在细观层次上,混凝土可以被看作由水泥基、分散粒子和界面过渡层组成的三相复合材料。首先,基于骨料分布和形态的随机特性,将瓦拉文公式推广应用于确定二维混凝土试件截面凸多边形骨料分布,提出圆形骨料模型中以圆骨料的面积为控制参数,以圆内接多边形为基架的凸多边形随机骨料算法。进而以C80高强高性能混凝土为例,对数值试样进行单轴受压的数值模拟,得到相应的应力-应变曲线和损伤演化图。数值模拟结果与物理试验结果对比表明本文提出的数值模型合理可行。  相似文献   

近海大气环境下钢框架自振频率评估研究          下载免费PDF全文

郑山锁  石磊  郑捷  周炎  张秋石  朱揽奇 《地震工程学报》2016,38(5):673-677

由于沿海地区的钢结构建筑常暴露在露天,不可避免地受到大气环境的腐蚀。本文在材料力学和结构分析的基础上,研究沿海地区钢框架结构自振频率的变化,进而对结构在近海大气环境下存在的潜在损伤进行评估。基于工字形与箱形截面,提出结构自振频率与结构构件厚度变化的关系式,并分别考虑构件内外表面腐蚀的影响。以一榀钢框架结构为例,分析其在腐蚀5、10、20年后结构前10阶自振频率的变化。分析结果表明,随着腐蚀程度的增加,结构自振频率降低的越大。研究成果可为锈蚀钢框架损伤评估提供一定的参考依据。  相似文献   

酪氨酸酶固定化碳材料对苯酚的生物降解性能     

刘娜  梁刚  董新维  祁小丽  杨悦锁  叶康  朴云仙 《吉林大学学报(地球科学版)》2017,47(2)

以新型碳材料氧化石墨烯作为载体,利用共价结合方法制备酪氨酸酶固定化氧化石墨烯复合物,并利用该复合物对苯酚进行催化降解,探讨酶的加载特性和酶的催化活性,以及固定化酪氨酸酶催化降解苯酚的最优条件及储存稳定性。通过对固定化酪氨酸酶进行活性和固定量分析后认为:单位质量载体的酶固定量为1.78 mg/mg,单位质量载体的酶活性为1 880.6 U/mg;固定化酪氨酸酶在30h内对47.06mg/L苯酚的降解率可达86.3%,降解反应的最优条件为pH=7.0、温度=25℃;固定化酪氨酸酶在4℃条件下30d后仍保持初始活性的77.7%,其稳定性优于游离酪氨酸酶。另外,在氧化石墨烯上引入磁颗粒,既简化了酶固定流程,又能做到回收利用。  相似文献   

Characterization of DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish (Dario rerio)     

孙威  谭训刚  张培军  张玉青  徐永立 《中国海洋湖沼学报》2010,(4)

Proteins of the DYRK(dual-specificity tyrosine-phosphorylation-regulated kinase) family are characterized by the presence of a conserved kinase domain and N-terminal DH box.DYRK2 is involved in regulating key developmental and cellular processes,such as neurogenesis,cell proliferation,cytokinesis,and cellular differentiation.Herein,we report that the ortholog of DYRK2 found in zebrafish shares about 70% identity with that of human,mouse,and chick.RT-PCR showed that DYRK2 is expressed maternally and zygotica...  相似文献   

Steroid sex hormone dynamics during estradiol-17β induced gonadal differentiation in Paralichthys olivaceus(Teleostei)     

孙鹏  尤锋  刘梦侠  吴志昊  文爱韵  李军  徐永立  张培军 《中国海洋湖沼学报》2010,(2)

Steroid sex hormones,such as estradiol-17β(E2)and testosterone(T),are important regulators of sex change in fish.In this study,we examined the effects of E2 treatment on the dynamics of E2 and T during gonadal differentiation in the olive flounder Paralichthys olivaceus using histology and radioimmunoassay(RIA).Flounder larvae were divided into five groups(G0–G4),and fed with 0 (control),0.2,2,20 and 100 mg E2/kg feed from 35 to 110 day post hatching(dph).Fish growth in the G1 and G2 groups was not significantly different from that of the control group(P0.05),while fish in the G3 and G4 groups were less active and showed growth depression and high mortality.The gonads of fish in the G3 and G4 groups were smaller and surrounded by hyperplastic connective tissue.The frequency of females in the G0–G4 groups was 54.5%,75.0%,100%,100%and 93.3%,respectively.The RIA analyses of E2 and T showed that T levels decreased during gonadal differentiation,and increased slightly at the onset of ovarian differentiation,while E2 levels increased gradually and peaked at the onset of ovarian differentiation in the control group.In the E2-treated groups,T levels decreased before the onset of ovarian differentiation.E2 levels were high on the 48 dph,but declined to a lower level on the 54 dph, and then increased gradually during gonadal differentiation.And a sharp increase of E2 levels were observed in all E2-treated groups at the onset of ovarian differentiation.The data suggest that T and E2 play important roles during gonadal differentiation,and an E2 dose of 2 mg/kg feed could induce sex reversal in P.olivaceus.  相似文献   

Quantitative comparison of the expression of myogenic regulatory factors in flounder (Paralichthys olivaceus) embryos and adult tissues     

张玉青  谭训刚  徐芃  孙威  徐永立  张培军 《中国海洋湖沼学报》2010,28(2):248-253

MyoD, Myf5, and myogenin are myogenic regulatory factors that play important roles during myogenesis. It is thought that MyoD and Myf5 are required for myogenic determination, while myogenin is important for terminal differentiation and lineage maintenance. To better understand the function of myogenic regulatory factors in muscle development of flounder, an important economic fish in Asia, real-time quantitative RT-PCR was used to characterize the expression patterns of MyoD, Myf5, and myogenin at early stages of embryo development, and in different tissues of the adult flounder. The results show that, Myf5 is the first gene to be expressed during the early stages of flounder development, followed by MyoD and myogenin. The expressions of Myf5, yoD, and myogenin at the early stages have a common characteristic: expression gradually increased to a peak level, and then gradually decreased to an extremely low level. In the adult flounder, the expression of the three genes in muscle is much higher than that in other tissues, indicating that they are important for muscle growth and maintenance of grown fish. During embryonic stages, the expression level of MyoD might serve an important role in the balance between muscle cell differentiation and proliferation. When the MyoD expression is over 30% of its highest level, the muscle cells enter the differentiation stage.  相似文献   

Steroid sex hormone dynamics during estradiol-17β induced gonadal differentiation in Paralichthys olivaceus (Teleostei)     

孙鹏  尤锋  刘梦侠  吴志昊  文爱韵  李军  徐永立  张培军 《中国海洋湖沼学报》2010,28(2):254-259

Steroid sex hormones, such as estradiol-17β (E2) and testosterone (T), are important regulators of sex change in fish. In this study, we examined the effects of E2 treatment on the dynamics of E2 and T during gonadal differentiation in the olive flounder Paralichthys olivaceus using histology and radioimmunoassay (RIA). Flounder larvae were divided into five groups (G0-G4), and fed with 0 (control), 0.2, 2, 20 and 100 mg E2/kg feed from 35 to 110 day post hatching (dph). Fish growth in the G1 and G2 groups was not significantly different from that of the control group (P>0.05), while fish in the G3 and G4 groups were less active and showed growth depression and high mortality. The gonads of fish in the G3 and G4 groups were smaller and surrounded by hyperplastic connective tissue. The frequency of females in the G0-G4 groups was 54.5%, 75.0%, 100%, 100% and 93.3%, respectively. The RIA analyses of E2 and T showed that T levels decreased during gonadal differentiation, and increased slightly at the onset of ovarian differentiation, while E2 levels increased gradually and peaked at the onset of ovarian differentiation in the control group. In the E2-treated groups, T levels decreased before the onset of ovarian differentiation. E2 levels were high on the 48 dph, but declined to a lower level on the 54 dph, and then increased gradually during gonadal differentiation. And a sharp increase of E2 levels were observed in all E2-treated groups at the onset of ovarian differentiation. The data suggest that T and E2 play important roles during gonadal differentiation, and an E2 dose of 2 mg/kg feed could induce sex reversal in P. olivaceus.  相似文献   

一般大气环境下钢筋锈蚀深度的RBF神经网络预测模型研究          下载免费PDF全文

王胜利  刘华  郑山锁  董淑卿  黄瑜 《地震工程学报》2024,(2):269-277

钢筋锈蚀深度预测是评估在役RC结构服役性能的基础。为建立一般大气环境RC构件中钢筋锈蚀深度预测模型,通过收集实测数据,分析影响钢筋锈蚀深度的主要参数及其影响规律,继而基于实测数据建立数值模型和RBF神经网络预测模型,并进行参数敏感性分析。研究结果表明:与数值模型相比,RBF神经网络对钢筋锈蚀深度预测效率与精度更高,能够有效映射各影响参数与钢筋锈蚀深度之间复杂的非线性关系。参数敏感性分析结果显示,钢筋混凝土表面锈胀裂缝宽度对钢筋锈蚀深度影响最大,钢筋直径、保护层厚度与钢筋直径之比和混凝土抗压强度等其他因素影响次之。所得模型可用于工程检测中钢筋锈蚀程度预测与RC构筑物剩余服役寿命评估。  相似文献