基于数据挖掘探析张奇文治疗癫痫的用药规          下载免费PDF全文

王默然  朱士高  刘茜茜 《应用海洋学学报》2024,40(2):18

目的：基于数据挖掘技术探析全国名中医张奇文治疗癫痫的用药规律。方法：收集1998年9月1日至2019年9月30日张奇文治疗癫痫的医案,对医案中的数据进行规范化处理,构建数据库,应用古今医案云平台V2.3.5对中药使用频次、四气五味、功效归经、关联、聚类等进行分析,并总结临床经验。结果：共筛选出40首处方,中药120味。排前10位的中药分别为全蝎、蜈蚣、僵蚕、炙甘草、麦芽、山楂、钩藤、羚羊角、珍珠、牛黄,药性以平、温为主,药味主要为甘、辛、苦,主要归肝、肺、脾经,功效以通络止痛、攻毒散结、息风镇痉等为主。关联组合支持度高的组合为全蝎-蜈蚣、全蝎-僵蚕、僵蚕-蜈蚣、钩藤-全蝎、钩藤-蜈蚣。结论：张奇文治疗癫痫标本兼顾,治标重视息风,治本重视健脾。  相似文献   

华北汛期降水异常与100hPa高度场异常的关系   总被引：4，自引：1，他引：4       下载免费PDF全文

孙燕  王谦谦  钱永甫  张友姝 《气象科学》2003,23(4):418-425

利用华北17站1951～2000年的逐月降水资料,与前期的100 hPa高度场(1958～1997年)求相关,找到了100 hPa高度场影响华北地区汛期降水的关键影响区为25°～35°N,85°～105°E,对应的关键影响时段为前一年3～5月.然后用SVD方法证实了前一年春季正是与华北汛期降水相关最显著的时段;而所选关键区正是处于一种范围更大的100 hPa高度场空间分布型的关键部位,而华北地区是关键区影响中国东部降水的最显著的区域之一.  相似文献   

Characteristics and Genetic Mechanisms of Overpressure in the Depressions of Bohai Bay Basin, China     

LIU Hu  JING Chen  JIANG Youlu  SONG Guoqi  YU Qianqian  FENG Yuelin 《《地质学报》英文版》2016,90(6):2216-2228

The distribution and genetic mechanisms of abnormal pressures in the Bohai Bay Basin were systematically analyzed. Abnormal pressures are widely developed in the Bohai Bay Basin, primarily in the Paleogene E2s4, E2s3, Es1, and Ed formations. From the onshore area of the Bohai Bay Basin to the center of the Bozhong area, the top depth of the overpressured zone in each depression increases gradually, the overpressured strata in each depression gradually move to younger formations, and the pressure structure successively alters from single-bottom- overpressure to double-bottom-overpressure and finally to double-top-overpressure. The distribution of overpressured area is consistent with the sedimentary migration controlled by the tectonic evolution of the Bohai Bay Basin, which is closely related to the hydrocarbon-generation capability of active source rocks. The overpressured strata are consistent with the source-rock intervals in each depression; the top of the overpressured zone is synchronous with the hydrocarbon generation threshold in each depression; the hydrocarbon generation capability is positively correlated with the overpressure magnitude in each formation. Undercompaction was the main mechanism of overpressure for depressions with fluid pressure coefficients less than 1.2, whereas hydrocarbon generation was the main mechanism for depressions with fluid pressure coefficients greater than 1.5.  相似文献   

Pharmacokinetics and acetylation of sulfamethoxazole in turbot <Emphasis Type="Italic">Scophthalmus maximus</Emphasis> after intravascular administration     

常志强  柳飞  连春盎  翟倩倩  李健 《中国海洋湖沼学报》2016,34(4):789-794

The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18°C were investigated. Either SMX (parent drug) or its acetylized metabolite, N₄-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two- and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h·kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.  相似文献   

Modelling coastal land use change by incorporating spatial autocorrelation into cellular automata models   总被引：1，自引：0，他引：1  

Yongjiu Feng  Qianqian Yang  Zhonghua Hong  Li Cui 《国际地球制图》2018,33(5):470-488

This paper presents a spatial autoregressive (SAR) method-based cellular automata (termed SAR-CA) model to simulate coastal land use change, by incorporating spatial autocorrelation into transition rules. The model captures the spatial relationships between explained and explanatory variables and then integrates them into CA transition rules. A conventional CA model (LogCA) based on logistic regression (LR) was studied as a comparison. These two CA models were applied to simulate urban land use change of coastal regions in Ningbo of China from 2000 to 2015. Compared to the LR method, the SAR model yielded smaller accumulated residuals that showed a random distribution in fitting the CA transition rules. The better-fitting SAR model performed well in simulating urban land use change and scored an overall accuracy of 85.3%, improving on the LogCA model by 3.6%. Landscape metrics showed that the pattern generated by the SAR-CA model has less difference with the observed pattern.  相似文献   

粤西河台金矿田糜棱岩XRD特征及其地质意义     

师爽  龚朝阳  焦骞骞  许德如  张胜印  常华诚  胡彬 《地质论评》2021,67(5):67060006-67060006

粤西河台金矿区位于钦州湾—杭州湾（钦—杭）结合带南段的云开地区,是典型的受韧性剪切带控制的金矿。然而,对于剪切带中有利于金成矿的地质环境及其成矿过程仍然存在争议。本文在对河台矿区高村矿床进行详细野外地质调查的基础上,通过X射线衍射（XRD）对含金剪切带中各类糜棱岩系列岩石进行系统研究,建立应力变化—成分变异的对比序列,从而进一步揭示剪切变形与金矿化的关系。结果显示,剪切带中白（绢）云母的含量在9%~40%,并且在初糜棱岩、无矿糜棱岩、含矿糜棱岩、无矿超糜棱岩、含矿超糜棱岩中含量呈现出逐渐递增的趋势。白（绢）云母主要为2M1型,b0值分布在0.55505~0.99002 nm之间,在初糜棱岩、无矿糜棱岩和无矿超糜棱岩中逐渐增高,分别形成在低压、中压和高压环境。可见,从初糜棱岩到超糜棱岩,随着变形强度的增加,热液活动也随之增强,从而新生成了大量白（绢）云母。然而,在含矿的糜棱岩和超糜棱岩中还存在一些低压白云母,推测其可能是在后期脆性裂隙中由于流体活动所新形成的。因此,成矿可能经历了两个阶段,即早期的韧性剪切变形阶段导致金的初步富集,后期叠加的脆性破裂阶段形成具有工业品位的矿体。另外,无矿超糜棱岩的石英含量（29.8%）明显低于糜棱岩（44.2%）,推测在形成石英脉型矿体过程中,部分热液可能来自于其围岩超糜棱岩。因此,相对于初糜棱岩和糜棱岩,超糜棱岩中更有利于金矿的形成。  相似文献   

Numerical　Modelling　of　the　Effects　of　Ozone　on　the　Summer　Atmospheric　Circulation     

Wang Qianqian  Wang Yinhui  Song Yu  Qian Yongfu 《大气科学进展》1994,11(2):201-211

ＮｕｍｅｒｉｃａｌＭｏｄｅｌｌｉｎｇｏｆｔｈｅＥｆｆｅｃｔｓｏｆＯｚｏｎｅｏｎｔｈｅＳｕｍｍｅｒＡｔｍｏｓｐｈｅｒｉｃＣｉｒｃｕｌａｔｉｏｎＷａｎｇＱｉａｎｑｉａｎ（王谦谦）；ＷａｎｇＹｉｎｈｕｉ（汪迎辉）；ＳｏｎｇＹｕ（宋煜）（Ｎａｍｉｎｇｉｎｓｔ...  相似文献   

江淮梅雨与冬季西太平洋海温的SVD分析   总被引：2，自引：0，他引：2  

毛文书  王谦谦  景艳  李如琦  杨霞 《气象》2007,33(8):83-89

利用江淮流域1954—2001年48年梅雨量资料和美国NCEP/NCAR1953—2001全球逐月海温再分析格点资料,网格距为2°×2°,采用EOF、合成分析和SVD分解等方法讨论了江淮梅雨与西太平洋海温的关系。结果表明:影响江淮梅雨的海温关键区是西太平洋暖池区,关键影响时段是前1年的12月至当年的2月(以下简称冬季);当年冬季西太平洋暖池区海温异常偏高,同年江淮大部地区梅雨量异常偏多,反之亦然。SVD分解结果与合成分析的结果相吻合,通过信度0.05的Monte-Carlo显著性检验。  相似文献   

声纳探测北极海冰吃水深度规律的仿真分析     

周康颖  李倩倩  李宏琳  史娟 《地理空间信息》2022,20(5):124-127

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Changes in the critical erosion velocity for sediment colonized by biofilm     

Hongwei Fang  Qianqian Shang  Minghong Chen  Guojian He 《Sedimentology》2014,61(3):648-659

In flowing water the incipient motion of sediment can be affected by the presence of microbial biofilm growth. This article documents a series of flume experiments using non‐uniform sediments, in which sediment entrainment was investigated for cases where the sediment was immersed in deionized water, so that no biofilm developed, and for cases where a bio‐sediment was cultivated by placing the sediment in a mixture of natural water and nutrient solution. Differences in entrainment and the velocity at incipient motion were measured over an eight week period, as biofilm grew. It was found that the incipient motion phenomena were quite distinct between the two kinds of sediment. Sediment with biofilm was more stable and, over time, incipient velocity increased to a threshold level, before declining. Biofilm development is clearly an important control on the stability of sediments, especially in eutrophic water bodies. Two incipient velocity formulas were derived for sliding and rolling conditions. Film water theory was utilized to describe the cohesive force between sediment particles and the adhesive force generated by biofilm was introduced into the formula derivation; the time variation characteristics of biofilm strength and the features of the substrate were also taken into consideration. Such analyses can help to predict sediment transport changes due to biofilm presence in nutrient‐rich water bodies.  相似文献