从肠道菌群-SCFAs探讨薯蓣粥对糖尿病合并脑卒中大鼠糖脂代谢的影响          下载免费PDF全文

洪雪珮  庞书勤  罗宗婷 《应用海洋学学报》2020,36(11):179

目的：从肠道菌群-短链脂肪酸（SCFAs）探讨薯蓣粥对糖尿病合并脑卒中大鼠糖脂代谢的影响。方法：选择SPF级wistar大鼠，使用腹部注射STZ、Zea Longa线栓法制作糖尿病合并缺血性脑卒中模型，成模后随机分为模型组、薯蓣粥组；另取一组为假手术组（不做尼龙单丝插入，其余造模过程均相同）。模型组、假手术组予0.9%氯化钠注射液5 ml灌胃，薯蓣粥组以薯蓣粥5 ml灌胃，共4周。干预后每周检测大鼠空腹血糖（FBG），干预结束后检测大鼠血糖、血脂4项［三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）］、脂联素（ADNP）、SCFAs水平肠道菌群多样性及物种丰度。结果：TG、TC、LDL-C、HDL-C、ADNP、SCFAs各指标，假手术组、薯蓣粥组与模型组比较，差异均有统计学意义（P＜0.05或P＜0.01）。干预第3、4周薯蓣粥组与模型组FBG比较，差异均有统计学意义（P＜0.05）。模型组的OUTs数量、Chaol指数、Shannon指数均低于假手术组，但Chaol指数、Shannou指数均高于薯蓣粥组，组间比较，差异均有统计学意义（P＜0.05或P＜0.01）。薯蓣粥组中，Clostridiales、Ruminococcaceae、Prevotella、LachnosPiraceae等能够促进SCFAs产生的菌属较模型组增多。结论：薯蓣粥可通过调控肠道菌群，增加SCFAs，从而改善糖尿病合并脑卒中大鼠的糖脂代谢。  相似文献   

大气污染物排放量与颗粒物环境空气质量的空间非协同耦合研究——以武汉市为例     

张金亭  赵玉丹  田扬戈  何青青  庄艳华  彭韵羲  洪松 《地理科学进展》2019,38(4):612-624

针对区域大气污染物排放量与空气质量在时空分布上存在不完全协同、匹配的现象,论文选择SO₂、NO_X、PM_2.5、CO和VOCs作为大气污染物指标,选择气溶胶光学厚度(Aerosol Optical Depth, AOD)表征颗粒物环境空气质量,以武汉市为例,综合应用耦合模型和空间错位指数模型研究2类指标之间的空间非协同耦合规律。主要结论如下：① 武汉市大气污染物排放量与颗粒物空气质量具有不同空间分布特征,大气污染物排放量呈现由城市中心城区向远城区递减的趋势,其中SO₂、PM_2.5和VOCs的排放具有明显的中心聚集现象,而NO_X和CO聚集现象不显著,且与道路分布明显相关;AOD分布具有明显的空间差异性,总体上呈由西北向东南依次递减的趋势。② 武汉市大气污染物排放与颗粒物空气质量的空间非协同耦合规律：越靠近城市中心城区,空间协同耦合现象越显著,空间错位现象越弱;越远离主城区,空间非协同耦合现象越显著,空间错位现象越显著;SO₂排放量与AOD在武汉市远城区的空间错位指数均大于0.7,且耦合度指数小于0.3,呈现较强的非协同耦合特征,NO_X、VOCs、PM_2.5的排放量与AOD在武汉中心城区的空间错位指数均小于0.5,且耦合度指数大于0.5,协同耦合现象较为显著。③ 基于时空非协同耦合分析城市大气环境污染治理建议：针对污染物与AOD空间错位不显著的城市中心城区,以本地减排治理为主;针对污染物与AOD空间错位显著的远城区,应在污染溯源分析的基础上进行区域协调综合治理。  相似文献   

基于GridMet模型的浙江省温湿指数空间分布及地形影响分析     

施国萍  何永健  张眉  邱新法  曾燕 《地球信息科学学报》2019,21(12):1923-1933

温湿指数是气候舒适度评价模型之一,通过温度与湿度的组合反映人体与周围环境的热量交换,本文利用2003-2018年浙江省及其周边71个气象站点月平均气温、地面水汽压数据,以及MODIS水汽产品,基于GridMet模型模拟了浙江省各月温湿指数空间分布（100 m×100 m）,分析了浙江省温湿指数随地形因子（海拔、坡度、坡向）变化的特征;讨论了各地形因子对温湿指数空间分布的影响程度。结果表明：① 海拔、坡度、坡向3个地形因子中,1月温湿指数随坡向的变化最大,7月最小;② 同坡向上,坡度变化对1月温湿指数影响较大,而海拔变化则是对7月影响最大;③ 南坡1月温湿指数随海拔和坡度增加均略为增加,南坡其他月份及北坡各月均为随海拔和坡度增加温湿指数减小;④ 北坡相对于南坡而言,海拔和坡度对温湿指数的影响更为明显。浙江大部分山区由于地形影响,夏季较为“舒适”,适宜建立避暑消夏的旅游项目。  相似文献   

BDS卫星失效对区域定位精度的影响评估     

徐炜  徐梅  严超  王涛 《大地测量与地球动力学》2018,38(11):1133-1136

基于STK软件实现了2016-09 BDS系统星座结构的仿真，并选取可见卫星数、DOP值、系统可用性作为评估BDS卫星星座设计结构的指标，分析单颗与全部倾斜轨道卫星（IGSO）、地球静止轨道卫星（GEO）失效后对我国大陆地区BDS系统可用性的影响。结果表明，IGSO4卫星与GEO5卫星失效后对BDS在区域的定位性能影响较大，失效后的GDOP值分别为1.98、2.16。取BDS卫星正常运行时区域平均GDOP最大值(S=2.60)作为系统可用性阈值时，系统可用性分别降低了1.79%、32.63%；阈值取2S(5.20)、3S(7.80)、4S(10.40)、5S(13.00)时，系统可用性均可达100.00%。GEO整体失效后BDS系统在高精度定位中仍部分可用，而IGSO整体失效后BDS系统可用性受到大幅度限制。因此，增加在轨备份卫星时需重点考虑GEO5、IGSO4，并适当增加IGSO卫星的数目。  相似文献   

Experimental study on the hydrological performance of green roofs in the application of novel biochar     

Shan Huang  Ankit Garg  Guoxiong Mei  Disheng Huang  Rahul Balaji Chandra  Shaji Gayathri Sadasiv 《水文研究》2020,34(23):4512-4525

Biochar has the potential to be a soil amendment in green roofs owing to its water retention, nutrient supply, and carbon sequestration application. The combined effects of biochar and vegetated soil on hydraulic performance (e.g., saturated hydraulic conductivity, retention and detention, and runoff delay) are the crucial factor for the application of the novel biochar in green roofs. Recent studies investigated soil water potential (i.e., suction) either on vegetated soil or on biochar-amended soil but rarely focused on their integrated application. With the purpose of investigating the hydraulic performance of green roofs in the application of biochar, the combined effect of biochar and vegetated soil on hydrological processes was explored. Artificial rainfall experiments were conducted on the four types of experimental soil columns, including natural soil, biochar-amended soil, vegetated natural soil, and vegetated biochar-amended soil. The surface ponding, bottom drainage and the volumetric water content were measured during the rainfall test. Simulation method by using HYDRUS-1D was adopted for estimating hydraulic parameters and developing modelling analysis. The results indicated that the saturated hydraulic conductivity of vegetated soil columns were higher than bare soil columns. The addition of biochar decreased the saturated hydraulic conductivity, and the magnitude of decrease was much significant in the case of vegetated soil. The influence of vegetation on permeability is more prominent than biochar. The vegetated biochar-amended soil has the highest retention and detention capacity, and shows a preferable runoff delay effect under heavy rain among the four soil columns. The results from the present study help to understand the hydrological processes in the green roof in the application of biochar, and imply that biochar can be an alternative soil amendment to improve the hydraulic performance.  相似文献   

南海沉积物细菌胞外蛋白酶在家族水平上的多样性   总被引：2，自引：0，他引：2  

杨金玉  冯阳阳  陈秀兰  解彬彬  张玉忠  石梅  张熙颖 《海洋学报(英文版)》2019,38(12):73-83

海洋产蛋白酶细菌及其分泌的胞外蛋白酶在降解有机氮以推动海洋氮循环进行方面发挥着重要作用，但目前对这二者多样性的认识非常有限。本研究自南海沉积物中筛选得到90株产蛋白酶细菌，并通过N-端氨基酸序列，分析了其胞外蛋白酶在家族水平上的多样性。16S rRNA基因序列分析的结果表明，筛选的产蛋白酶细菌均属于Gammaproteobacteria纲，且大多数属于Alteromonadales目和Vibrionales目的不同属。对其中14株菌株的14个胞外蛋白酶的N-端氨基酸序列分析表明，所有这些蛋白酶属于金属蛋白酶的M4家族或丝氨酸蛋白酶的S8家族。本研究提供了海洋沉积物产蛋白酶细菌在类群及其胞外蛋白酶在类型上的新细节，这将有助于全面了解微生物酶促降解海洋沉积物有机氮的过程和机理。  相似文献   

Dissolved organic matter in surface runoff in the Loess Plateau of China: The role of rainfall events and land-use     

Zhongwu Li  Hao Peng  Binggeng Xie  Chun Liu  Xiaodong Nie  Danyang Wang  Mei Huang  Haibing Xiao  Lin Shi  Xuqin Zhang  Jieyu Jiang 《水文研究》2020,34(6):1446-1459

Exploring the chemical characterization of dissolved organic matter (DOM) is important for understanding the fate of laterally transported organic matter in watersheds. We hypothesized that differences in water-extractable organic matter (WEOM) in soils of varying land uses and rainfall events may significantly affect the quality and the quantity of stream DOM. To test our hypotheses, characteristics of rainfall-runoff DOM and WEOM of source materials (topsoil from different land uses and gullies, as well as typical vegetation) were investigated at two adjacent catchments in the Loess Plateau of China, using ultraviolet–visible absorbance and excitation emission matrix fluorescence with parallel factor analysis (PARAFAC). Results indicated that land-use types may significantly affect the chemical composition of soil WEOM, including its aromaticity, molecular weight, and degree of humification. The PARAFAC analysis demonstrated that the soils and stream water were dominated by terrestrial/allochthonous humic-like substances and microbial transformable humic-like fluorophores. Shifts in the fluorescence properties of stream DOM suggested a pronounced change in the relative proportion of allochthonous versus autochthonous material under different rainfall patterns and land uses. For example, high proportions of forestland could provide more allochthonous DOM input. This study highlights the relevance of soils and hydrological dynamics on the composition and fluxes of DOM issuing from watersheds. The composition of DOM in soils was influenced by land-use type. Precipitation patterns influenced the proportion of terrestrial versus microbial origins of DOM in surface runoff. Contributions of allochthonous, terrestrially derived DOM inputs were highest from forested landscapes.  相似文献   

黑潮流域海温适应性观测敏感区诊断方法研究     

崔宝龙  笪良龙  过武宏  韩梅 《海洋科学》2018,42(7):80-86

敏感区诊断是适应性观测的关键问题,集合变换卡尔曼方法(EnsembleTransformKalmanFilter,ETKF)是目前主要的诊断方法之一。将集合变换卡尔曼方法应用于海洋环境适应性观测,根据ROMS海洋模式数据构建海表温度集合预报,以黑潮流域宫古海峡附近海域为验证区进行敏感区诊断计算,分析不同间隔时间条件下敏感区分布情况,结合模拟系统观测试验验证在敏感区进行适应性观测对预报质量的提升效果。结果表明,在诊断所得敏感区内添加观测能够提升预报质量;随时间间隔增大,敏感区向上游区域平移且预报质量提升效果减小;与在验证区整体添加观测相比,敏感区观测对预报质量提升效果基本相同并且观测成本明显减少。  相似文献   

中国海洋无脊椎动物分类学与系统演化研究进展与展望     

李新正  寇琦  王金宝  甘志彬  杨梅  龚琳  隋吉星  马林  曲寒雪  初雁凌  曾宥维  王伟娜  张祺  董栋 《海洋科学》2020,44(7):26-70

综述了我国海域无脊椎动物的分类学和系统演化研究的历史和概况，以及我国分类系统学工作者在海洋无脊椎动物分类学、区系与动物地理学、系统发育与分子系统学领域的主要工作，重点介绍了中国科学院海洋研究所的海洋无脊椎动物分类学工作。涉及类群包括原生动物、海绵动物、刺胞动物、线虫、多毛类环节动物、星虫、螠虫、软体动物、节肢动物、苔藓动物、毛颚动物、棘皮动物、半索动物等主要的无脊椎动物门类。涉及海域以我国管辖海域，特别是中国近海为主，也涉及了西太平洋、西南印度洋等深海环境的无脊椎动物类群的分类学报道。本文总结过去，展望未来，对于在我国在海洋无脊椎动物分类与系统演化研究领域成就基础上，发现薄弱环节，研讨今后本学科的发展方向，填补研究空白，赶超本领域国际前沿，都有重要借鉴意义。  相似文献   

One-dimensional consolidation of soil under multistage load based on continuous drainage boundary     

Yi--> Tian  Wenbing Wu  Guosheng Jiang  M. Hesham El Naggar  Guoxiong Mei  Meijuan Xu  Rongzhu Liang 《国际地质力学数值与分析法杂志》2020,44(8):1170-1183

In engineering practice, a rapid loading rate can result in ground failure when the strength of soft soils is relatively low, and a multistage loading scheme is always utilized to deal with this situation. Firstly, under a multistage load and the continuous drainage boundary, an analytical solution of excess pore-water pressure and consolidation degree is obtained by virtue of the superposition formula of excess pore-water pressure, and a more general continuous drainage boundary under arbitrary time-dependent load is developed. Then, a comparison with existing analytical solutions is conducted to verify the present solution. A preliminary attempt on applying the continuous drainage boundary into the finite element model is made, and the feasibility of the numerical model for the one-dimensional consolidation under the continuous drainage boundary is verified by comparing the results calculated by FEM with that from present analytical solution. Finally, the consolidation behavior of soil is investigated in detail for different int erface parameters or loading scheme. The results show that, in land reclamation projects, a horizontal drain should be placed close to the boundary with a smaller interface parameter to improve the consolidation efficiency. The degree of consolidation is also related to the applied time-dependent load and interface parameters.  相似文献