参附注射液建立自发性高血压病大鼠肝阳上亢证模型的研究          下载免费PDF全文

周梦  杨文丽  刘晓庆 《应用海洋学学报》2018,34(12):120-122

目的：探讨参附注射液建立自发性高血压大鼠（SHR）模型的可能性。方法：将30只3月龄SPF级健康雄性自发性高血压大鼠称重,随机分为SHR组,附子汤组,参附注射液低、中、高剂量组,每组6只。各组采用对应药物灌胃进行模型制备,另取同品系同周龄雄性魏-凯二氏大鼠（WKY）6只作为正常对照组（WKY组）。观察参附注射液对SHR大鼠24h饮水量、易激惹程度、痛阈、睑结膜充血及收缩压的影响。结果：附子汤组及参附注射液中、高剂量组造模后均出现了易激惹程度增高、睑结膜充血程度增高、饮水量增多、痛阈降低、收缩压升高等肝阳上亢的表现,与WKY组及SHR组比较,差异有统计学意义（P<0.05),表明造模成功。结论：参附注射液可以制备新型高血压肝阳上亢证模型,但是具体造模机制以及造模药物用量需待进一步探讨确定。  相似文献   

p-y曲线对成层土体中大直径单桩的适用性研究          下载免费PDF全文

孟晓伟  翟恩地  许成顺 《海洋技术学报》2019,38(2)

API规范推荐的p-y曲线是由均质土体得到的,并未考虑土层间相互作用,Georgiadis基于柔性桩提出了等效深度法修正p-y曲线,把均质土p-y曲线延伸到了成层土体中。为了研究p-y曲线和等效深度法对于大直径单桩在成层土体中的适用性,取4种典型地质条件:成层砂土、砂土-黏土-砂土、成层黏土和黏土-砂土-黏土,通过L-PILE软件计算了6 m直径单桩基础的p-y曲线、桩顶水平荷载-位移曲线、桩身位移和弯矩。并与ABAQUS建立的单桩基础三维有限元模型计算结果进行比较。结果表明等效深度法对于成层砂土影响不大;对于成层黏土影响较大;对于中间为软弱土层的成层土体,在荷载较大时影响显著,等效深度法计算结果更加接近FEM结果。在成层土体中,p-y曲线应用于大直径单桩对于砂土高估了初始刚度,低估了极限抗力;对于黏土则低估了初始刚度和极限抗力。  相似文献   

闽江河口区沉积物中的抗生素分布特征及生态风险评价          下载免费PDF全文

刘四光  张乐蒙  李赫男  陈猛  陈岚  王键  张钒 《应用海洋学学报》2020,39(2):162-171

采用固相萃取和液相色谱串联质谱(HPLC-MS/MS)分析方法对闽江河口区域沉积物中8类54种抗生素的含量以及分布特征进行分析探讨,并利用熵值法对抗生素的生态风险进行评价。结果表明,闽江河口区域24个站点共检出6类(大环内酯类、磺胺类、喹诺酮类、氯霉素类、硝基咪唑类和苯并咪唑类)19种抗生素,总量范围在4.16~64.74 ng/g,平均值为17.35 ng/g;其中大环内酯类、喹诺酮类和硝基咪唑类抗生素检出频率达到100%。抗生素总量的空间分布情况呈闽江河口上游>北港>南港>河口下游的趋势,人口密集区生活污水和医疗废水排放是上游和北港沉积物大环内脂类和喹诺酮类抗生素含量较高的主要原因,而海水养殖过程中的直接投放可能是河口下游硝基咪唑类抗生素的主要来源;生态风险评价结果显示,大部分抗生素的生态风险值RQ<1,然而替米考星和甲硝唑在研究区域的RQ>1,具有一定的潜在风险,可能会对该区域生态环境产生负面效应。  相似文献   

溢油乳化过程C波段微波散射特性实验研究     

舒思京  孟俊敏  张晰  过杰  刘根旺 《海洋学报(英文版)》2020,39(7):135-145

本文基于水槽溢油观测实验,研究溢油乳化过程中表面散射特性的变化。利用全极化C波段微波散射计和矢量网络分析仪等测量设备对易发生乳化反应沥青含量小于3%的原油（A型油）、油田中开采出的新鲜原油（B型油）和经过脱水去杂质处理的工业原油（C型油）进行观测。文中详细分析了在C波段微波下乳化油膜与平静水面的后向散射差异,以及油膜乳化过程对后向散射的影响,结果显示在低风速、无浪的条件下（最大波高低于3mm）,原油的乳化反应可通过表面粗糙度和自身介电常数的变化来调制雷达后向散射,并且这两种方式中表面粗糙度的影响占主导地位。对比B型和C型原油在乳化状态和未乳化状态下的表面后向散射,结果显示在各状态下B型油膜表面后向散射均大于C型油,且在VV、HH、HV/VH极化方式下两者后向散射平均差异分别为2.19 dB、2.63 dB、2.21 dB,在20%油膜含水率的乳化状态下差异较未乳化状态时小,平均差异分别为0.98 dB、1.49 dB、1.5 dB,结果表明不同类型油种间由于成分和油膜属性的不同会在一定程度上导致油膜表面粗糙度存在差异,影响油膜表面后向散射。  相似文献   

多氯联苯(Aroclor 1242)胁迫下鲤鱼肝脏组织氧化应激   总被引：1，自引：0，他引：1  

王仁君  王建国  丁宁  孙萌  高配科 《海洋与湖沼》2018,49(6):1286-1293

本文在实验室条件下通过静态水质染毒方式在生理生化和转录水平上探究了我国重要经济鱼种鲤鱼(Cyprinus carpioio)对多氯联苯Aroclor 1242的氧化应激:鲤鱼肝脏组织抗氧化酶[超氧化物歧化酶(SuperoxideDismutase,SOD)和过氧化氢酶(Catalase,CAT)]活性、脂质过氧化产物丙二醛(Malonydialdehyde,MDA)含量、相关抗氧化酶编码基因(Cu/Zn-SOD、Mn-SOD、CAT)、应激蛋白HSP70、转录因子Nrf2和芳烃受体AhR2基因表达。结果表明:Aroclor 1242胁迫下,鲤鱼肝脏组织抗氧化酶活性表现出低浓度促进高浓度抑制的趋势;肝脏组织丙二醛含量显著升高,其中390μg/L暴露组鲤鱼肝脏组织MDA含量在第6d高于对照组92.1%(P0.01),表明肝脏组织发生脂质过氧化,膜系统受到损伤;鲤鱼肝脏组织中Cu/Zn-SOD、Mn-SOD、CAT、HSP70、Nrf2和AhR2编码基因表达出现不同程度下调。本文从酶学和基因转录水平上揭示了Aroclor1242胁迫下鲤鱼肝脏组织细胞的氧化应激。  相似文献   

基于多源遥感数据的日本海内波特征研究   总被引：2，自引：1，他引：1  

孙丽娜  张杰  孟俊敏  王晶  张旭东 《海洋学报》2018,40(3):102-111

日本海特殊的地理位置和复杂的地形使得该海域内波表征极为复杂,遥感是大范围观测内波的有效手段,已被广泛应用于内波的探测研究。本文利用MODIS、GF-1和ENVISAT ASAR遥感影像,开展了日本海内波特征研究。通过提取内波波峰线,生成了日本海内波空间分布图;获取了内波的波峰线长度和传播速度,并基于非线性薛定谔方程反演了内波振幅。研究结果表明,日本海内波分布范围宽广,不仅大陆架沿海区内波分布密集,深海盆地也探测到了大量内波;日本海北部45°N附近海域有少量内波出现,利用高分影像探测到朝鲜陆架浅海区有大量小尺度内波,大和海盆、大和隆起的西南部海域没有发现内波。日本海内波波峰线长达100多千米,深海区的传播速度大于1 m/s;浅海区内波振幅约10 m左右,深海区可达60 m以上。  相似文献   

Dynamic Performance Investigation of A Spar-Type Floating Wind Turbine Under Different Sea Conditions     

Han Wang  Zhi-qiang Hu  Xiang-yin Meng 《中国海洋工程》2018,32(3):256-265

Both numerical calculation and model test are important techniques to study and forecast the dynamic responses of the floating offshore wind turbine (FOWT). However, both the methods have their own limitations at present. In this study, the dynamic responses of a 5 MW OC3 spar-type floating wind turbine designed for a water depth of 200 m are numerically investigated and validated by a 1:50 scaled model test. Moreover, the discrepancies between the numerical calculations and model tests are obtained and discussed. According to the discussions, it is found that the surge and pitch are coupled with the mooring tensions, but the heave is independent of them. Surge and pitch are mainly induced by wave under wind wave conditions. Wind and current will induce the low-frequency average responses, while wave will induce the fluctuation ranges of the responses. In addition, wave will induce the wavefrequency responses but wind and current will restrain the ranges of the responses.  相似文献   

PHoToNs–A parallel heterogeneous and threads oriented code for cosmological N-body simulation     

Qiao Wang  Zong-Yan Cao  Liang Gao  Xue-Bin Chi  Chen Meng  Jie Wang  Long Wang 《天文和天体物理学研究(英文版)》2018,(6)

We introduce a new code for cosmological simulations, PHo To Ns, which incorporates features for performing massive cosmological simulations on heterogeneous high performance computer(HPC) systems and threads oriented programming. PHo To Ns adopts a hybrid scheme to compute gravitational force, with the conventional Particle-Mesh(PM) algorithm to compute the long-range force,the Tree algorithm to compute the short range force and the direct summation Particle-Particle(PP) algorithm to compute gravity from very close particles. A self-similar space filling a Peano-Hilbert curve is used to decompose the computing domain. Threads programming is advantageously used to more flexibly manage the domain communication, PM calculation and synchronization, as well as Dual Tree Traversal on the CPU+MIC platform. PHo To Ns scales well and efficiency of the PP kernel achieves68.6% of peak performance on MIC and 74.4% on CPU platforms. We also test the accuracy of the code against the much used Gadget-2 in the community and found excellent agreement.  相似文献   

Binary Star Fractions from the LAMOST DR4     

Zhi-Jia Tian  Xiao-Wei Liu  Hai-Bo Yuan  Bing-Qiu Chen  Mao-Sheng Xiang  Yang Huang  Chun Wang  Hua-Wei Zhang  Jin-Cheng Guo  Juan-Juan Ren  Zhi-Ying Huo  Yong Yang  Meng Zhang  Shao-Lan Bi  Wu-Ming Yang  Kang Liu  Xian-Fei Zhang  Tan-Da Li  Ya-Qian Wu  Jing-Hua Zhang 《天文和天体物理学研究(英文版)》2018,(5)

Stellar systems composed of single, double, triple or higher-order systems are rightfully regarded as the fundamental building blocks of the Milky Way. Binary stars play an important role in formation and evolution of the Galaxy. Through comparing the radial velocity variations from multiepoch observations, we analyze the binary fraction of dwarf stars observed with LAMOST. Effects of different model assumptions, such as orbital period distributions on the estimate of binary fractions,are investigated. The results based on log-normal distribution of orbital periods reproduce the previous complete analyses better than the power-law distribution. We find that the binary fraction increases with Teff and decreases with [Fe/H]. We first investigate the relation between α-elements and binary fraction in such a large sample as provided by LAMOST. The old stars with high [α/Fe] dominate with a higher binary fraction than young stars with low [α/Fe]. At the same mass, earlier forming stars possess a higher binary fraction than newly forming ones, which may be related with evolution of the Galaxy.  相似文献   

An algorithm to resolve γ-rays from charged cosmic rays with DAMPE     

Zun-Lei Xu  Kai-Kai Duan  Zhao-Qiang Shen  Shi-Jun Lei  Tie-Kuang Dong  Fabio Gargano  Simone Garrappa  Dong-Ya Guo  Wei Jiang  Xiang Li  Yun-Feng Liang  Mario Nicola Mazziotta  Maria Fernanda Munoz Salinas  Meng Su  Valerio Vagelli  Qiang Yuan  Chuan Yue  Jing-Jing Zang  Ya-Peng Zhang  Yun-Long Zhang  Stephan Zimmer 《天文和天体物理学研究(英文版)》2018,(3)

The DArk Matter Particle Explorer(DAMPE),also known as Wukong in China,which was launched on 2015 December 17,is a new high energy cosmic ray and γ-ray satellite-borne observatory.One of the main scientific goals of DAMPE is to observe Ge V-Te V high energy γ-rays with accurate energy,angular and time resolution,to indirectly search for dark matter particles and for the study of high energy astrophysics. Due to the comparatively higher fluxes of charged cosmic rays with respect to γ-rays,it is challenging to identify γ-rays with sufficiently high efficiency,minimizing the amount of charged cosmic ray contamination. In this work we present a method to identify γ-rays in DAMPE data based on Monte Carlo simulations,using the powerful electromagnetic/hadronic shower discrimination provided by the calorimeter and the veto detection of charged particles provided by the plastic scintillation detector. Monte Carlo simulations show that after this selection the number of electrons and protons that contaminate the selected γ-ray events at～10 Ge V amounts to less than 1% of the selected sample.Finally,we use flight data to verify the effectiveness of the method by highlighting known γ-ray sources in the sky and by reconstructing preliminary light curves of the Geminga pulsar.  相似文献