疏风宣肺汤对慢性支气管炎大鼠p38 MAPK/ATF-2信号转导通路的影响     

姜若愚  闵锐  范伏元 《应用海洋学学报》2019,35(2):133-136

目的：探讨疏风宣肺汤对慢性支气管炎大鼠p38MAPK/ATF-2信号转导通路的作用。方法：将SD大鼠随机分为空白对照组、模型组、疏风宣肺汤组、宣肺止嗽合剂组，采用混合烟雾吸入法建立慢性支气管炎大鼠模型，分别给予相应药物进行干预。检测各组大鼠p38MAPK蛋白表达含量、肺泡巨噬细胞计数、ATF-2蛋白表达含量。结果：疏风宣肺汤组能够明显降低p38MAPK蛋白表达含量、肺泡巨噬细胞计数及ATF-2蛋白表达含量，其治疗效果优于宣肺止嗽合剂组，差异均有统计学意义（P＜0.05）。结论:疏风宣肺汤可能是通过抑制p38MAPK/ATF-2信号通路表达，发挥对慢性支气管炎的治疗作用。  相似文献   

台风风暴潮灾害影响下的温州平阳县脆弱性评估          下载免费PDF全文

马静武  乔观民  陈甫源  周浩 《海洋开发与管理》2019,36(9):43-51

浙江是频繁遭遇台风风暴潮袭击的省份,而温州地区受潮灾尤为严重,为给其防御台风风暴潮提供管理支持,文章以平阳县为例,利用气候变化脆弱性分析框架,分析灾害暴露性、脆弱性特征和适应能力,提出平阳县适应风暴潮灾害的对策。在适应能力评估上,从经济与社会发展、城市基础设施、保护性设施、灾害管理机构能力和机制等4个方面构建沿海城市防御风暴潮灾害能力评价指标体系,采用AHP层次分析法评估平阳防御灾害能力。研究结果表明:(1)平阳具有较高的灾害暴露性。(2)增加脆弱性的主要因素包括围填海新区扩张与城市建设、存在的部分低质量房屋、城市排水管网系统和部分海堤标准较低、基层社区灾害应对能力相对不足等。(3)平阳防御风暴潮灾害能力的评估值为0.796。建议将风暴潮灾害因素纳入国土空间规划考虑;健全灾害管理机构和机制;加固重点堤防,改进城市排水系统;提高农房等建筑的防洪抗台能力;提升基层社区的减灾能力。  相似文献   

Geochronological and geochemical study of mafic dykes from the northwest Chinese Altai: Implications for petrogenesis and tectonic evolution   总被引：4，自引：0，他引：4  

Keda Cai  Min Sun  Chao Yuan  Guochun Zhao  Wenjiao Xiao  Xiaoping Long  Fuyuan Wu 《Gondwana Research》2010,18(4):638-652

Fifteen zircons separated from a mafic dyke in the Chinese Altai give a concordant age population with a weighted mean ²⁰⁶Pb/²³⁸U age of 375.5 ± 4.8 Ma, suggesting a Devonian emplacement. On the basis of their mineralogical compositions and textures, the coeval dykes can be divided into gabbroic and doleritic types. They are both sub-alkaline, tholeiitic, characterized by similarly low SiO₂ contents (45.2–52.7 wt.%) and total alkaline (K₂O + Na₂O = 0.99–4.93 wt.%). Rare earth element patterns of the gabbroic dykes are similar to N-MORB (La/Yb_N = 0.86–1.1), together with their high ε_Nd(t) values (+ 7.6 to + 8.1), indicating that their precursor magma was mainly derived from a N-MORB-type depleted asthenospheric mantle. While the REE patterns of the doleritic dykes resemble that of E-MORB (La/Yb_N = 1.12–2.28), enriched in LILEs and strongly depleted in HFSEs, with relative low ε_Nd(t) values (+ 3.4 to + 5.4) and high initial ⁸⁷Sr/⁸⁶Sr ratios (0.7057–0.7060). The zircon Hf isotopic analysis of the doleritic dykes give ε_Hf(t) values from + 10.7 to + 13.8. These signatures suggest that a depleted mantle wedge metasomatized by slab-derived fluids and/or melts was possibly involved in the generation of the doleritic magma. The refractory peridotite may have been melted with variable degrees caused by upwelling of the hot asthenosphere. The petrogenesis of the mafic dykes suggest a high heat flux as a result of upwelling of the hot asthenosphere and the contrast geochemical signatures can be interpreted by a ridge subduction, which could be an important tectonic control in the accretionary process of the Chinese Altai.  相似文献   

Zircon U–Pb and Hf isotopic study of Mesozoic felsic rocks from eastern Zhejiang,South China: Geochemical contrast between the Yangtze and Cathaysia blocks     

Jean Wong  Min Sun  Guangfu Xing  Xian-hua Li  Guochun Zhao  Kenny Wong  Fuyuan Wu 《Gondwana Research》2011,19(1):244-259

The Jiangshan–Shaoxing Fault Zone (JSFZ) in Zhejiang Province has been proposed to represent a suture between the Yangtze and Cathaysia blocks in South China. In this study, in-situ zircon U–Pb and Hf isotopic analysis and whole-rock major- and trace-element measurement of early to middle Cretaceous felsic rocks across the fault zone were conducted to constrain the nature of the fault zone. Twelve Cretaceous granitoid bodies were sampled from the NW and SE sides of the fault zone, respectively, with composition ranging from diorite to granite (SiO₂ = 56.2–76.6 wt.%). These granitoids yielded U–Pb ages ranging from 135–100 Ma, with a systematic variation in zircon Hf isotopic compositions (ε_Hf(t) = + 6.9 to –7.0 in the NW side vs. + 1.9 to ? 12.9 in the SE side). The T_DM2 values for the granitoids from the NW side are 0.34 to 1.33 Ga, with two peaks at ca. 876 and 1170 Ma respectively, whereas those from the SE side are 0.70 to 1.62 Ga, with a single peak at ca. 1126 Ma. The Hf isotopic disparity for the two sides may indicate a fundamental difference in the lower crustal compositions of the Yangtze and Cathaysia blocks, supporting that the JSFZ is possibly a suture zone between the two blocks. Our results together with the available geological data suggest that the Mesoproterozoic materials are important for both the Yangtze and Cathaysia basement and the Neoproterozoic magmatic activities were important in the Yangtze Block, possibly related to the break-up of the Rodinia supercontinent, but less significant in the Cathaysia Block. This may imply that the two blocks have not completely juxtaposed in the Neoproterozoic.  相似文献   

紧邻既有建筑深基坑工程的常见安全问题分析及控制要点     

宋福渊  胡贺祥  郭恒 《岩土工程技术》2014,28(6):271-274

对紧邻既有建筑深基坑工程常见安全问题进行了全面而深入地分析,并提出了深基坑支护施工中的安全控制要点,为类似基坑工程的安全和顺利实施提供了解决思路。  相似文献   

珠江三角洲城市群区域绿道与生态游憩空间的连接度与分布模式   总被引：1，自引：0，他引：1  

王甫园  王开泳 《地理科学进展》2019,38(3):428-440

绿道对城市群构建连续的生态开放空间网络具有重要作用。基于珠三角城市群现有区域绿道网络,采用拓扑网络和社会网络分析评估生态游憩空间的连接度,揭示生态游憩空间联系的空间分布模式,结果表明：“生态游憩空间-区域绿道”拓扑网络的α、β、γ指数分别为0、0.386、0.129,说明网络中点和边较少,网络为树状形,环通性不高,总体连接度较低;绿道对生态游憩空间的连接度呈集群式分布,且处在边缘的凝聚子群连接度高于中心地区的子群;各集群之间的连接度呈现出东部-北部区域大于西部、东西部之间空间分割性比较明显的格局;连接度分布模式的形成主要受绿道政策与布局、绿道建设机制、生态游憩空间规模集聚格局、地理阻隔与空间邻近性的影响。最后,论文提出了优化“生态游憩空间-绿道”分布模式、构建连接度更高的生态开放空间系统的路径,给中国城市群规划和发展提供参考。  相似文献   

县市分等方法及中国县市等第特征的分异规律   总被引：1，自引：0，他引：1  

李一飞  王开泳  王甫园 《地理研究》2020,39(4):772-786

对行政区进行适当分类管理是提高行政管理效率的重要手段。县市分等是行政区分类管理的重要内容,也是“因地制宜”推进行政区划管理的直接体现,对于提升地方治理能力和治理水平、激发发展活力和释放发展动能具有重要意义。系统梳理中国县市统计数据,综合运用层次分析法、K均值聚类法等提出县市分等方法,并对县市等第特征的分异规律进行分析。结果显示：① 人口规模是影响县市分等的主要因素,其次是面积和地区生产总值,公共财政支出的影响相对较小。各等第县市数量大体呈梯形分布,高等第县市间差异较大,不同等第县市地域分布存在不均衡现象。② 县市分等管理在实践中具有可行性,按照人口、地理、经济、管理难度分等的方法具有合理性。③ 县市分等过程中,可以考虑采取分省份、按比例的方法对县市等第进行划分,对县市差异小、分等使用的单方面指标值较高县市相对集中,以及县市数量少的省份可以给予特殊安排。④ 在推进国家治理现代化背景下,县市分等的现实需求更加凸显,有助于新时期对不同县市分类施策,促进县市间良性竞争与协同发展。  相似文献   

Coupled U-Pb Dating and Hf Isotopic Analysis of Detrital Zircon of Modern River Sand From the Yalu River (YarlungTsangpo) Drainage System in Southern Tibet:Constraints on the Transport Processes and Evolution of Himalayan Rivers     

ZHANG Jinyu  YIN An  LIU Wencan  WU Fuyuan  DING Lin  GROVE Marty 《《地质学报》英文版》2013,87(Z1):102-102

  相似文献   

长三角地区产业转型的大气污染效应——基于空间溢出视角     

CHEN Yufan  XU Yong  WANG Fuyuan 《地理学报(英文版)》2022,32(1):156-176

The Yangtze River Delta(YRD) is a region in China with a serious contradiction between economic growth and environmental pollution. Exploring the spatiotemporal effects and influencing factors of air pollution in the region is highly important for formulating policies to promote the high-quality development of urban industries. This study uses the spatial Durbin model(SDM) to analyze the local direct and spatial spillover effects of industrial transformation on air pollution and quantifies the contribution of each factor. From 2008 to 2018, there was a significant spatial agglomeration of industrial sulfur dioxide emissions(ISDE) in the YRD, and every 1% increase in ISDE led to a synchronous increase of 0.603% in the ISDE in adjacent cities. The industrial scale index(ISCI) and industrial structure index(ISTI), as the core factors of industrial transformation, significantly affect the emissions of sulfur dioxide in the YRD, and the elastic coefficients are 0.677 and-0.368, respectively. The order of the direct effect of the explanatory variables on local ISDE is ISCI>ISTI>foreign direct investment(FDI)>enterprise technological innovation(ETI)>environmental regulation(ER)> per capita GDP(PGDP). Similarly, the order of the spatial spillover effect of all variables on ISDE in adjacent cities is ISCI>PGDP>FDI>ETI>ISTI>ER, and the coefficients of the ISCI and ISTI are 1.531 and 0.113, respectively. This study contributes to the existing research that verifies the environmental Kuznets curve in the YRD, denies the pollution heaven hypothesis, indicates the Porter hypothesis, and provides empirical evidence for the formation mechanism of regional environmental pollution from a spatial spillover perspective.  相似文献   

南海东部重矿物分布特征及其影响因素   总被引：3，自引：1，他引：3  

杨群慧  林振宏  张富元  林晓彤  季福武 《中国海洋大学学报(自然科学版)》2002,32(6):956-964

对南海东部 1 88个站位表层沉积物样品 63～ 1 2 5μm粒级重矿物的研究表明 ,重矿物种类有50种 ,最高含量可达 1 2 .82 % ;平均含量较低 ,为 1 .1 1 % ,;矿物组成以普通角闪石、铁锰微结核、磁铁矿、普通辉石为主。重矿物来源复杂多样 ,包括陆源、火山、自生等各种来源的矿物。陆源重矿物多分布在水深 3 50 0 m以浅的北部陆坡 ,主要来源于台湾海峡和台湾岛 ;此外还有经巴士海峡由洋流带入的吕宋岛等的剥蚀物 ,珠江物质对研究区的影响较小。自生沉积矿物主要分布于 1 6°N～ 2 0°N之间的下陆坡区和深海平原 ,其中铁锰微结核富集于沉积速率较低的氧化环境 ,自生黄铁矿则富集于局部还原环境或生物壳室中。火山碎屑矿物主要分布于 1 5°N两侧的深海平原和海山区 ,来源于海底火山岩的剥蚀物和附近弧状列岛的火山喷发物。沉积环境是影响重矿物分布的主要因素。  相似文献